Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity

Kim, Ki Ohk; Ku, Chang-Sub; Kim, Min-Gon; Park, Yhun Jung; Ryu, Hyung Won; Song, Hyuk‐Hwan; Kim, Jung Hee; Oh, Sei‐Ryang

doi:10.3839/jabc.2015.004

Cited by 7 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Polyphenols found in plant extracts have numerous bioactive functions [28]. Total phenolic contents of NFAJ and FAJ were 2.52 mg and 5.75 mg GAE per 100 g of dry mass, respectively (data not shown).…”

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 94%

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Mijan¹,

Park²,

Lee³

et al. 2018

Nat Prod Chem Res

View full text Add to dashboard Cite

Achyranthes japonica Nakai (AJ) is a medicinal plant and has well-known health benefits. This study has evaluated the antioxidant and anti-inflammatory activities of the fermented extract of AJ (FAJ). Fermentation of the extract increased the total phenolic and flavonoid contents of AJ. FAJ showed significantly higher free radical scavenging activities as compared with NFAJ. In addition, FAJ exhibited higher ferric (Fe 3+ ) reducing activity than NFAJ. FAJ inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) in lipopolysaccharide (LPS)induced RAW 264.7 cells at a higher level than NFAJ without affecting the cell viability. The mRNA expression of tumor necrosis factor α (TNF-α) in RAW 264.7 cells was substantially reduced by FAJ treatment. Moreover, the upregulation of pp38 and protein kinase RNA-like endoplasmic reticulum kinase (pERK) by LPS in RAW 264.7 cells was markedly suppressed by FAJ. These results suggest that FAJ has therapeutic potential as an antioxidant and anti-inflammatory agent.

show abstract

Section: Total Phenolic and Flavonoid Contentsmentioning

confidence: 94%

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Mijan¹,

Park²,

Lee³

et al. 2018

Nat Prod Chem Res

View full text Add to dashboard Cite

show abstract

“…원지는 신경 안정 효과가 있다 [16]. 우슬은 혈액순 환을 촉진하고, 혈액을 생성하는 효능이 있어 머리가 희는 것 을 방지하고 탈모를 치료하며, 항 아토피 효과가 있다 [17]. 더구나 10가지 기능성 소재 모두 항산화능이 있다고 알려져 있다 [18][19][20] ABTS radical scavenging activity (%)…”

unclassified

Development and Evaluation of the Herbal Medicine for Hair Growth-promoting Activity

최선경¹,

조남준²,

김기광³

2016

KSBB Journal

View full text Add to dashboard Cite

Hair loss affects both men and women of all ages and often significantly affects social and psychologic health. Recent therapeutic approach for hair loss such as finasteride and minoxidil focused on regulation of hormonal system blood flow. However, long-term use of these drugs caused adverse effects. To develop herbal medicine for therapeutic effect on hair growth, here we screened the 10 medicinal herbs (Red ginseng, Licorice, Ulmus, Barberry root, Lycium root, Rehmanniae radix crudus, Sophora root, Sweet flag, Polygala root, Achyranthes) based on oriental medicine literature. We measured cytotoxicity, anti-oxidant activity, and 5-α reductase inhibitory effect of the herbal medicine on human dermal papilla (DP) cells to investigate therapeutic effect of the herbal medicine. Treatment of the 1% herbal medicine did not show any cytotoxic effects, and cell growth was increased by treatment of the 0.1% herbal medicine. In addition, the herbal medicine showed stronger antioxidant activity than resveratrol and comparable inhibitory activity of 5-α reductase with finasteride. Furthermore, when applied to in vivo mouse model, we also observed increases in the number and length of hair of the herbal medicine-treated group. These results suggest that the herbal medicine promotes hair growth by its antioxidant activity and inhibitory activity of 5-α reductase and might therefore be a promising hair growth-promoting agent.

show abstract

Purification of triterpenoid saponins and 25R/25S‐inokosterone from Achyranthes bidentata Bl. by high‐speed countercurrent chromatography coupled silver nitrate coordination

Niu,

Yu,

Wang

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

An effective method by high‐speed countercurrent chromatography coordinated with silver nitrate for the preparative separation of sterones and triterpenoid saponins from Achyranthes bidentata Blume was developed. Methyl tert‐butyl ether/n‐butanol/acetonitrile/water (4:2:3:8, v/v/v/v) was selected for 20‐hydroxyecdysone (compound 1), chikusetsusaponin IVa methyl ester (compound 4), 2′‐glycan‐11‐keto‐pigmented saponin V (compound 5), as well as a pair of isomers of 25S‐inokosterone (compound 2) and 25R‐inokosterone (compound 3), which were further purified by silver nitrate coordinated high‐speed countercurrent chromatography. What is more, dichloromethane/methanol/isopropanol/water (6:6:1:4, v/v/v/v) was applied for calenduloside E (compound 6), 3β‐[(O‐β‐d‐glucuronopyranosyl)‐oxy]‐oleana‐11,13‐dien‐28‐oic acid (compound 7), zingibroside R1 (compound 8) and chikusetsusaponin IVa (compound 9). Adding Ag+ to the solvent system resulted in unique selectivity for 25R/25S isomers of inokosterone, which increased the complexing capability and stability of Ag+ coordinated 25S‐inokosterone, as well as the α value between them. These results were further confirmed by the computational calculation of geometry optimization and frontier molecular orbitals assay. Comprehensive mass spectrometry and nuclear magnetic resonance analysis demonstrated the structures of the obtained compounds.

show abstract

Phytoecdysones from the Roots of Achyranthes japonica Nakai and their Anti-atopy Activity

Cited by 7 publications

References 18 publications

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Evaluation of the Antioxidant and Anti-Inflammatory Potential of Fermented Achyranthes japonica Nakai Extract

Development and Evaluation of the Herbal Medicine for Hair Growth-promoting Activity

Purification of triterpenoid saponins and 25R/25S‐inokosterone from Achyranthes bidentata Bl. by high‐speed countercurrent chromatography coupled silver nitrate coordination

Contact Info

Product

Resources

About