Phytoecdysteroids: Isolation and Biological Applications

Naggar, Yahya Al

doi:10.11648/j.ajls.20170501.12

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Thus, the positive effect of the application of phytoecdysteroid-containing cream in SD patients may be associated with the normalization of the keratinocytes differentiation process. It is postulated [ 34 , 35 ] that ecdysones may have a significant impact on the reduction of inflammation, probably due to their immunomodulatory function and the modulation of the level of the pro-inflammatory cytokine (e.g.,interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α)). Moreover, it has been reported that phytoecdysteroids improve skin quality by accelerating the healing of wounds and burns [ 36 , 37 ].Several studies [ 38 ] have claimed associations between Malassezia restricta lipase and SD.…”

Section: Resultsmentioning

confidence: 99%

Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Napierała

Nawrot

Gornowicz‐Porowska

et al. 2020

IJERPH

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Phytoecdysteroids are natural compounds with therapeutic benefits in both humans and animals. The effectiveness of natural products with health potential is based on the activities and potencies of their active ingredients. In this study, dominant ecdysteroids—ajugasterone C, 20-hydroxyecdysone and polypodine B—from the Serratula coronata (S. coronata) herb were separated by column chromatography, identified by spectroscopic data and quantified by high-performance liquid chromatography with a diode array detector (HPLC-DAD). The obtained concentration of ecdysteroids (approximately 23%) in the S. coronatae herb extract enhances the possibility of their use in pharmaceutical and cosmetic products with high levels of phytoecdysteroids. Moreover, this study has shown a positive effect of ecdysteroids-containing cream on changes in quality of life and a beneficial effect in reducing the symptoms of seborrheic dermatitis. It has been demonstrated that the application of the cream with phytoecdysteroids resulted in a statistically significant alleviation of symptoms (p < 0.05), especially in terms of itching, pain or burning sensations in the affected areas in comparison to previous symptoms.

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Section: Resultsmentioning

confidence: 99%

Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Napierała

Nawrot

Gornowicz‐Porowska

et al. 2020

IJERPH

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“…39 The significant activity towards reducing inflammation might be due to its immunomodulatory function and modulation of proinflammatory cytokines (IL-6 and TNF-). 40 …”

Section: Discussionmentioning

confidence: 99%

Herbal Therapy for the Treatment of Seborrhea Dermatitis

Mustarichie¹,

Rostinawati²,

Pitaloka³

et al. 2022

CCID

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Seborrhea dermatitis is a skin disorder that usually appears on parts of the body that have high density of sebaceous glands, such as the face, chest, and scalp. Clinical manifestations that generally appear as scaly skin and erythema. Seborrhea dermatitis is also known as one of the causes of alopecia. Treatments that can be used for seborrhea dermatitis are antifungal, anti-inflammatory, keratolytic, and coal tar. There are concerns about poor adherence, resistance, and some side effects of drugs that have been used in the treatment of seborrhea dermatitis. Concerns regarding these issues increase the urgency for the development of new therapeutic agents in the treatment of seborrhea dermatitis. Research on medicinal plants has enormous potential to produce compounds with new structures and bioactivity. This review discusses clinical and in vitro studies related to the activity of several medicinal plants that have potential as a treatment for seborrhea dermatitis, as well as the compounds that play a role in these activities. Literature searches were carried out on the PubMed, Taylor & Francis, and SpringerLink databases using Boolean Operators to get 25 articles that match the keywords used. Of the 25 articles, six were clinical trials, while 19 were in vitro studies of Malassezia. Several plants have potential as promising therapeutic agents for the treatment of seborrhea dermatitis by inhibiting the growth of Malassezia, decreasing sebum secretion, and decreasing symptoms associated with seborrhea dermatitis such as itching, pain or burning sensation, and redness.

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“…In our experiments, adult weevils did hardly accept spinach for feeding, which could be due to phytoecdysteroids contained in spinach leaves. Spinach is among the plants with the highest content of these substances (Grebenok et al 1994;Al Naggar et al 2017), which have previously been found to deter feeding of several Coleopteran species (Jurenka et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Suitability of Amaranthaceae and Polygonaceae species as food source for the sugar beet weevil Asproparthenis punctiventris Germar

2022

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This study explores the food plant spectrum of the sugar beet weevil (Asproparthenis punctiventris Germar; Coleoptera: Curculionidae), one of the most important pests of sugar beet (Beta vulgaris subsp. vulgaris Altissima group). It examines the potential of various weeds and other plants to maintain populations of A. punctiventris adults and larvae outside sugar beet fields. To this end, leaf consumption of females and males on twelve Amaranthaceae and six Polygonaceae species was compared over a 24-h period in a laboratory environment. Both sexes consumed the greatest amount of leaf mass from Beta spp. and on average about a third less from Atriplex spp., indicating that these plants have the highest nutritional value for A. punctiventris. Weevils consumed between 30 and 60% of the amount of A. retroflexus and Chenopodium spp. than they fed on sugar beet leaves. Like Spinacia oleracea (Amaranthaceae), plant species of the Polygonaceae family were hardly or not at all fed on. Mated females generally consumed more leaf mass than unmated, especially from Chenopodium spp. and A. retroflexus, i.e. plants with low feeding value. Experiments with potted plants revealed that the most and heaviest 4th instar larvae developed on sugar beet, while fewer individuals with lesser weight were found on B. vulgaris subsp. maritima and A. hortensis. Very few larvae were able to develop on C. album, and none on A. retroflexus. To prevent promotion of pest population, special attention should be paid to the control of weeds from the Amaranthaceae family in sugar beet growing areas.

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Phytoecdysteroids: Isolation and Biological Applications

Cited by 10 publications

References 13 publications

Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Separation and HPLC Characterization of Active Natural Steroids in a Standardized Extract from the Serratula coronata Herb with Antiseborrheic Dermatitis Activity

Herbal Therapy for the Treatment of Seborrhea Dermatitis

Suitability of Amaranthaceae and Polygonaceae species as food source for the sugar beet weevil Asproparthenis punctiventris Germar

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