Phytoestrogen consumption and risk for cognitive decline and dementia: With consideration of thyroid status and other possible mediators

Soni, Mira; White, Lon R.; Kridawati, Atik; Bandelow, Stephan; Hogervorst, Eef

doi:10.1016/j.jsbmb.2015.10.024

Cited by 19 publications

(8 citation statements)

References 106 publications

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“…However, when we sampled tofu in Jakarta we could not find any evidence of this, but the practice may have been abolished after it became illegal. We also found similar negative associations of tofu and brain function in elderly in Hawai'i (Soni et al 2016) and China (Xu 2014). In contrast, in women of middle-age we found that the phytoestrogens present in tofu protected against poor memory (Hogervorst 2011).…”

Section: East Asian Diets: Fruit and Soy Productssupporting

confidence: 72%

“…We found associations in people of East Asian origin. In addition, tempe, a soy product that is fermented and contains B vitamins, such as folate and vitamin B12, was found to improve memory and reduce dementia risk and amyloid markers in both humans and animals (Kridawati, 2015, Soni, 2016, Hogervorst, 2010. It may be that folate off-sets potential negative effects of high levels of estrogens (Hogervorst, 2010) Activities: physical and cognitive stimulation Exercise can lower blood pressure, total cholesterol and improve cardiovascular function.…”

Section: East Asian Diets: Fruit and Soy Productsmentioning

confidence: 99%

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Healthy lifestyles to prevent dementia and reduce dementia symptoms

Hogervorst

2017

WWOP

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Citation: HOGERVOIST, E., 2017 AbstractPurpose Dementia is a growing problem worldwide, due to an ageing population. It has significant human and economic costs. There is no effective medical treatment.Design/methodology Using earlier reviews, we discuss the difference between dementia and cognitive ageing and the different types of dementia, in terms of manifestation and pathology. We reviewed non-modifiable risk factors for dementia, such as age, gender, genetics and education. Education can possibly have lifelong protective effects, as it may promote cognitive reserve. This paper focused on lifestyle interventions to further increase brain reserve capacity. Findings from earlier reviews were summarised to provide guidelines for policymakers and practioners.Findings Our reviews suggested that most nutritional approaches may have limited effectiveness, and should be implemented in midlife, before dementia symptoms are present and probably only in people who are actually nutritionally deficient. We found a reasonable positive evidence base of engagement in cognitive and physical activities to prevent dementia, which may also help reduce symptoms of dementia. Practical and social implicationsFrom the studies reviewed, it was suggested that keeping physically and mentally active may help in all stages of life to prevent, but also reduce dementia symptoms. A focus on nutrition and treating heart disease risk factors is possibly limited to midlife, or before dementia symptoms are present. OrginalityWe used an evidence based approach to review which lifestyle interventions could help prevent dementia or reduce dementia symptoms. The main outcome of this paper was that stage of life and ability (dementia present or not) may interact with success of the intervention

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Section: East Asian Diets: Fruit and Soy Productssupporting

confidence: 72%

Section: East Asian Diets: Fruit and Soy Productsmentioning

confidence: 99%

Healthy lifestyles to prevent dementia and reduce dementia symptoms

Hogervorst

2017

WWOP

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“…In a recent review paper ( 25 ) , of observational studies reviewed, only 23 % reported positive effects, 31 % found negative effects, 31 % found no effect of phytoestrogen consumption on cognition and 15 % found mixed effects. Negative associations of high tofu intake with a higher dementia risk and worse global cognitive and memory function were found in Indonesian, Japanese American and Chinese populations aged 65 and over ( 15 , 26 – 30 ) . These associations were independent of socioeconomic status, education, age, or intake of other foods.…”

Section: Soya and Cognitionmentioning

confidence: 98%

“…Hypothyroidism is associated with lower cognition function and is relatively common, especially in older women ( 41 ) . However, when analysing this directly, thyroid function was not shown to mediate the negative association between high tofu intake and dementia risk ( 30 ) .…”

Section: Soya and Cognitionmentioning

confidence: 99%

Nutrition research in cognitive impairment/dementia, with a focus on soya and folate

et al. 2017

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“…Níveis mais altos de T4 e total estão consistentemente associados a demência e DA 21 . Até mesmo em níveis elevados normais, há comprometimento cognitivo após acompanhamento de dois anos 21 .A doença em sua forma subclínica é associada a um risco 3x maior de DA7 , encontrada, em estudo, relação somente em homens21 .A patologia é relacionada a ruptura do sistema colinérgico e ao estresse oxidativo sistêmico12 .CONCLUSÃOO artigo demonstra a complexidade potencial da relação entre os HTs e a DA, propiciando melhor entendimento da fisiopatologia, tratamento e prevenção da demência. O enfoque no tratamento da doença tireoidiana, mesmo que subclínica, pode ser importante para diminuir a incidência da doença.…”

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Envolvimento dos hormônios tireoidianos no desenvolvimento e progressão da Doença de Alzheimer

Reis¹,

Savaris²,

Marques³

2020

Rev Neurocienc

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Introdução. Os hormônios tireoidianos (HTs) são relatados como fatores associados às doenças neurodegenerativas, como a doença de Alzheimer (DA). Objetivo. Analisar a relação entre os hormônios tireoidianos na prevenção e desenvolvimento da doença de Alzheimer. Método. Trata-se de uma revisão integrativa, a partir do levantamento de informações nas bases de dados Science Direct e PubMed. As estratégias de busca estabelecidas foram fundamentais em suas combinações, na língua inglesa, para garantir busca mais ampla. Quanto aos critérios de inclusão para a seleção de artigos: artigos completos e disponíveis, publicados em inglês, entre o período de 2009 até 2020. Artigos incompletos e não disponíveis, publicados anteriormente ao ano de 2009, em outra língua que não o inglês, e artigos redundantes e que não apresentavam relação com o tema, foram excluídos. Resultados. A glândula tireoide e seus diversos distúrbios possuem íntima relação no funcionamento fisiológico e patológico cerebral, podendo estar relacionado ao desenvolvimento, progressão e tratamento de doenças neurodegenerativas, especialmente com a doença de Alzheimer (DA), apesar das atuais evidências ainda não serem claras. Conclusão. São necessárias mais pesquisas para desvendar o elo fisiopatológico causal exato entre a função da tireoide e a demência. Definir mecanismos fisiopatológicos causais não apenas fornece mais informações sobre o desenvolvimento da demência, como também pode descobrir possíveis triagens futuras ou novas opções de tratamento.

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Phytoestrogen consumption and risk for cognitive decline and dementia: With consideration of thyroid status and other possible mediators

Cited by 19 publications

References 106 publications

Healthy lifestyles to prevent dementia and reduce dementia symptoms

Healthy lifestyles to prevent dementia and reduce dementia symptoms

Nutrition research in cognitive impairment/dementia, with a focus on soya and folate

Envolvimento dos hormônios tireoidianos no desenvolvimento e progressão da Doença de Alzheimer

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