Phytoestrogenic effects of black tea extract (Camellia sinensis) in an oophorectomized rat (Rattus norvegicus) model of osteoporosis

Das, Asankur Sekhar; Das, Dolan; Mukherjee, Maitrayee; Mukherjee, Sandip; Mitra, Chandan

doi:10.1016/j.lfs.2005.02.035

Cited by 46 publications

(35 citation statements)

References 17 publications

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“…Femur bone volume (BV) is measured using the plethysmometric method (Archimedes' principle), and bone density (g/mL BV) is calculated [35]. Femur external diameter can also be measured at the midshaft [36].…”

Section: Bone Physical Parametersmentioning

confidence: 99%

Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis

Satpathy

Patra

Ahirwar

2015

Journal of Complementary and Integrative Medicine

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Postmenopausal osteoporosis, a silent epidemic, has become a major health hazard, afflicting about 50% of postmenopausal women worldwide and is thought to be a disease with one of the highest incidences in senile people. It is a chronic, progressive condition associated with micro-architectural deterioration of bone tissue that results in low bone mass, decreased bone strength that predisposes to an increased risk of fracture. Women are more likely to develop osteoporosis than men due to reduction in estrogen during menopause which leads to decline in bone formation and increase in bone resorption activity. Estrogen is able to suppress the production of proinflammatory cytokines like interleukin (IL)-1, IL-6, IL-7 and tumor necrosis factor (TNF-α). This is why these cytokines are elevated in postmenopausal women. In this review article we have made an attempt to collate the various methods and parameters most frequently used for screening of antiosteoporotic activity in postmenopausal osteoporosis. Pertaining to ovariectomized animal model, this is the most appropriate model for studying the efficacy of different drugs to prevent bone loss in postmenopausal osteoporosis.

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Section: Bone Physical Parametersmentioning

confidence: 99%

Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis

Satpathy

Patra

Ahirwar

2015

Journal of Complementary and Integrative Medicine

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“…Both black tea and green tea contain polyphenols with anti-inflammatory 39 and antioxidant properties. 40 The range of benefits that humans derive from green tea consumption has not yet been conclusively determined, but in animal models for osteoporosis and in in vitro studies, tea has been positively correlated with bone health both by increasing bone formation [41][42][43][44] and decreasing bone reabsorption. [45][46][47][48] To date, no negative correlations have been reported between tea consumption and BMD levels (see Shen et al 39 for more details).…”

Section: Family Theaceaementioning

confidence: 99%

Alternative therapies for the prevention and treatment of osteoporosis

2012

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Osteoporosis is a medical condition that affects millions of men and women. People with this condition have low bone mass, which places them at increased risk for bone fracture after minor trauma. The surgeries and treatments required to repair and heal bone fractures involve long recovery periods and can be expensive. Because osteoporosis occurs frequently in the elderly, the financial burden it places on society is likely to be large. In the United States, the Food and Drug Administration has approved several drugs for use in the prevention and treatment of osteoporosis. However, all of the currently available agents have severe side effects that limit their efficacy and underscore the urgent need for new treatment options. One promising approach is the development of alternative (nonpharmaceutical) strategies for bone maintenance, as well as for the prevention and treatment of osteoporosis. This review examines the currently available nonpharmaceutical alternatives that have been evaluated in in vitro and in vivo studies. Certain plants from the following families have shown the greatest benefits on bone: Alliceae, Asteraceae, Thecaceae, Fabaceae, Oleaceae, Rosaceae, Ranunculaceae, Vitaceae, Zingiberaceae. The present review discusses the most promising findings from studies of these plant families.

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“…Green tea extract and bioactive components found in it, especially tea polyphenols, could effectively improve bone quality by stimulating osteoblast differentiation and suppressing osteoclast formation and differentiation (Shen et al, 2009, 2011; Oka et al, 2012; Byun et al, 2014; Vester et al, 2014). Furthermore, black tea water extract was shown to increase serum estradiol (E 2 ) levels and prevent against estrogen deficiency-related osteoporotic damage in an oophorectomized rat model of osteoporosis (Das et al, 2005). However, whether Pu-erh tea has anti-osteoporotic potential has not been well elucidated.…”

Section: Introductionmentioning

confidence: 99%

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

et al. 2017

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Background and Objective: Tea drinking is associated with positive effects on bone health and may protect against osteoporosis, especially in elderly women. Pu-erh tea has many beneficial effects on human health; however, whether Pu-erh tea has anti-osteoporotic potential remains unclear. Thus, we investigated the effects of Pu-erh tea extract (PTE) on ovariectomy-induced osteoporosis in rats and on osteoclastogenesis in vitro.Methods: Female Wistar rats were divided into six groups: the sham, model, and Xian-Ling-Gu-Bao capsule (XLGB) groups, and the low-, medium-, and high-dose PTE groups. Ovariectomized (OVX) rats were used as an animal model of osteoporosis. The animals were intragastrically administered distilled water, XLGB, or different concentrations of PTE for 13 weeks. Body weight, blood biochemical indicators, relative organ coefficients, femoral bone mineral density (BMD), bone biomechanical properties, and bone microarchitecture were examined and analyzed. Additionally, the in vitro effects of PTE on osteoclastic activities were investigated using the RAW 264.7 cell line as an osteoclast differentiation model. The effects of PTE on osteoclast differentiation and the expression of osteoclast-specific genes and proteins were determined.Results: PTE reduced OVX-induced body weight gain after 6 weeks of treatment, and the high-dose exerted a significant effect. High-dose PTE significantly ameliorated OVX-induced estradiol (E2) deficiency. PTE treatment maintained calcium and phosphorus homeostasis and improved other blood biochemical parameters to various degrees. In addition, PTE treatment improved organ coefficients of the femur, uterus, and vagina and improved femoral BMD and bone biomechanical properties. PTE treatment strikingly ameliorated bone microarchitecture. Moreover, in the in vitro studies, osteoclast differentiation using the differentiation cell model was significantly inhibited by PTE without cytotoxic effects. Additionally, PTE efficaciously suppressed the expression of key osteoclast-specific genes and proteins.Conclusion: PTE can ameliorate ovariectomy-induced osteoporosis in rats and suppress osteoclastogenesis in vitro.

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Phytoestrogenic effects of black tea extract (Camellia sinensis) in an oophorectomized rat (Rattus norvegicus) model of osteoporosis

Cited by 46 publications

References 17 publications

Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis

Experimental techniques for screening of antiosteoporotic activity in postmenopausal osteoporosis

Alternative therapies for the prevention and treatment of osteoporosis

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

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