Phytoestrogens: A Viable Option?

Russell, Lori; Hicks, G. Swink; Low, Annette K.; Shepherd, Jinna M.; Brown, C. Andrew

doi:10.1097/00000441-200210000-00004

Cited by 61 publications

(47 citation statements)

References 7 publications

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“…4) Diosgenin has been applied to hormone replacement therapy in menopausal women. 5,6) Estrogen enhanced the proliferation of estrogen-dependent cancer cells, 7) whereas diosgenin inhibited the proliferation of breast cancer cells. 8) Oral administration of diosgenin improved reduced skin thickness in ovariectomized mice.…”

Section: Diosgenin (mentioning

confidence: 99%

Enhancement of Diosgenin Distribution in the Skin by Cyclodextrin Complexation Following Oral Administration

Okawara

Tokudome

Todo

et al. 2013

Biological & Pharmaceutical Bulletin

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Orally administrated diosgenin, a steroidal saponin found in several plants including Dioscorea villosa, recovers skin thickness reduced in ovariectomized mice, and plays an important role in the treatment of hyperlipidemia. Thus, diosgenin is an active element of cosmeceutical and dietary supplements. However, we have already elucidated that the skin distribution and absolute oral bioavailability of diosgenin is very low. The aim of this study is to evaluate the efficacy of diosgenin-cyclodextrin (CD) complexes in improving the skin concentration of diosgenin. The formation of the CD complex was indicated by powder X-ray diffraction (XRD), differential scanning calorimetry (DSC), and scanning electron microscope (SEM) studies. Oral administration of the diosgenin/β-CD complex resulted in a significant enhancement in terms of the skin distribution of diosgenin, maximum plasma level (C max ), area under the plasma concentration-time curve (AUC), and absolute oral bioavailability over those of the drug alone. These results suggest that the inclusion complex of diosgenin/β-CD can be used to improve low skin content of diosgenin.

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Section: Diosgenin (mentioning

confidence: 99%

Enhancement of Diosgenin Distribution in the Skin by Cyclodextrin Complexation Following Oral Administration

Okawara

Tokudome

Todo

et al. 2013

Biological & Pharmaceutical Bulletin

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“…Given the prevalence of sexual problems during menopause, women's interest in taking complementary medicine to reduce the symptoms of menopause (13), use of herbal medicines with less side effects and accelerating the treatment procedure, positive impact of Ginkgo biloba in some studies, studying the plant in different doses and population (18,19) and the lack of research about the effects of aromatherapy on sexual function, this study aimed to evaluate the combined effect of herbal therapy by Ginkgo biloba and aromatherapy on sexual function in postmenopausal women.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Ginkgo biloba Tablet and Aromatherapy Inhaler Combination on Sexual Function in Females During Postmenopausal Period: A Double-Blind Randomized Controlled Trial

Malakouti¹,

Jabbari²,

Asghari-Jafarabadi³

et al. 2016

International Journal of Women’s Health and Reproduction Scienc

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“…Phytoestrogens are being increasingly used as an alternative to hormone therapy by women who either have contraindications or do not wish conventional estrogen replacement. Consequently, there is increasing interest in enlightening the effects of phytoestrogens on different aspects of women's health, such as vascular biology, bone metabolism, breast cancer, or menopausal symptoms (Russell et al, 2002;Ososki and Kennelly, 2003).…”

mentioning

confidence: 99%

Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells

Hermenegildo¹,

Oviedo²,

Garcı́a-Pérez³

et al. 2005

J Pharmacol Exp Ther

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The molecular mechanisms of the vascular effects of phytoestrogens are poorly studied. Prostacyclin is a potent vasodilator synthesized by two isoforms of cyclooxygenase (COX) in endothelium. This study examine the effects of two phytoestrogens, the isoflavones genistein and daidzein, on prostacyclin production by cultured human umbilical vein endothelial cells (HUVECs) and the possible role of not only estrogen receptors but also both COX isoforms. The two phytoestrogens significantly increased prostacyclin release in a time-and dosedependent (0.01-1 M) manner, being higher than control after 24 h. Selective inhibitors of COX-1, SC-560 [5-(4-chlorophenyl)-1-(4-methoxypjenyl)-3-(trifluoromethyl)-1H-pyrazole], and COX-2, NS-398 (N-[2-(cyclohexyloxy)-4 nitrophenyl]-methanesulfonamide), were used to investigate the relative contribution of each enzyme. Both inhibitors decreased basal production of prostacyclin, but only COX-2 inhibition completely abolished the isoflavone-stimulated prostacyclin production. Phytoestrogens also increased COX-2 mRNA expression and protein content without affecting COX-1 levels. All these effects were mediated through estrogen receptor activation since treatment of cells with the estrogen receptor antagonist ICI 182780 [7␣-[9[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17␤ diol] completely abolished the isoflavone-induced increase in prostacyclin production, COX-2 mRNA expression, and COX-2 protein content. The results clearly support the hypothesis that genistein and daidzein increased HUVEC prostacyclin production through estrogen receptor-dependent mechanism, which involved the enhancement of COX-2 protein and activity.

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Phytoestrogens: A Viable Option?

Cited by 61 publications

References 7 publications

Enhancement of Diosgenin Distribution in the Skin by Cyclodextrin Complexation Following Oral Administration

Enhancement of Diosgenin Distribution in the Skin by Cyclodextrin Complexation Following Oral Administration

The Impact of Ginkgo biloba Tablet and Aromatherapy Inhaler Combination on Sexual Function in Females During Postmenopausal Period: A Double-Blind Randomized Controlled Trial

Effects of Phytoestrogens Genistein and Daidzein on Prostacyclin Production by Human Endothelial Cells

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