Phytoestrogens alter the reproductive organ development in the mink (Mustela vison)

Ryökkynen, Ari; Nieminen, Petteri; Mustonen, Anne‐Mari; Pyykönen, Teija; Asikainen, Juha; Hänninen, Sari; Mononen, Jaakko; Kukkonen, Jussi V. K.

doi:10.1016/j.taap.2004.06.012

Cited by 13 publications

(6 citation statements)

References 34 publications

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“…Testicular weight is therefore a frequently used endpoint in controlled laboratory studies of the impact of EDCs on reproduction. According to Ryokkynen et al [ 37 ], oestrogenic substances such as phytoestrogens increase testicular weight in male mink kits exposed during gestation and lactation. In male rats exposed to environmental oestrogens in utero and during neonatal development, testicular weight decreases as they reach adult age [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Pre-Fixation Delay and Freezing on Mink Testicular Endpoints for Environmental Research

et al. 2015

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There is growing interest in using wild animals to monitor the real-life cocktail effect of environmental chemicals on male reproduction. However, practical difficulties, such as long distances to the laboratory, generally prolong the time between euthanisation and specimen handling. For instance, tissue fixation is often performed on frozen material or on material where deterioration has started, which may affect tissue morphology. This study examined the effect of pre-fixation delay and freezing on mink testicular endpoints in order to determine robust endpoints in suboptimally handled specimens. Sexually mature farmed mink (n=30) selected at culling were divided into six groups and subjected to different time intervals between euthanisation and fixation or freezing: 0 hours (fixed immediately post mortem), 6 hours, 18 hours, 30 hours, 42 hours, or frozen 6 hours post mortem and thawed overnight. Unaffected endpoints when pre-fixation storage was extended to 30 hours included: area and diameter of the seminiferous tubules, length and weight of the testes, and acrosomes marked with Gata-4. Epithelial height, Sertoli cells marked with Gata-4 and cell morphology were affected endpoints after 6 hours of storage. Freezing the tissue prior to fixation severely altered cell morphology and reduced testicular weight, tubular diameter and area. Morphological changes seen after 6 hours included shredded germ cells and excess cytoplasm in seminiferous tubular lumen, chromatin rearrangements and increased germ cell death. Extended delay before fixation and freezing affected many endpoints in the mink testicular tissue. Some of these endpoints may mimic chemically induced effects, which is important to consider when evaluating specimens from wild animals for environmental toxicity.

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Section: Discussionmentioning

confidence: 99%

Effect of Pre-Fixation Delay and Freezing on Mink Testicular Endpoints for Environmental Research

et al. 2015

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“…In farm animals, genistein had adjuvant effects in stimulating antibody response (Hu et al, 2003). In mink animals, genistein help in reproductive organ development (Ryoekkynen et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

2011

Egypt. J. Rad.Sci.

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“…β-sitosterol can also be used as a plant hormone, can increase the weight of reproductive organs. Increasing the weight of the reproductive organs can trigger an anti-aging effect [ 86 ]. It has been shown that the hypothalamus plays an important role in the development of aging and that this effect of the hypothalamus is mediated by a decrease of the NF-κB -oriented gonadotropin-releasing hormone (GnRH).…”

Section: Beta-sitosterolmentioning

confidence: 99%

Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent

et al. 2017

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Lycium barbarum has been used in China for more than 2,000 years as a traditional medicinal herb and food supplement. Lycium barbarum contains abundant Lycium barbarum polysaccharides (LBPs), betaine, phenolics, carotenoids (zeaxanthin and β-carotene), cerebroside, 2-O-β-d-glucopyranosyl-l-ascorbic acid (AA-2βG), β-sitosterol, flavonoids and vitamins (in particular, riboflavin, thiamine, and ascorbic acid). LBPs are the primary active components of Lycium barbarum. In this review, we discuss the pharmacological activities of LBPs and other major components. They have been reported to mediate significant anti-aging effects, through antioxidant, immunoregulative, anti-apoptotic activities and reducing DNA damage. Thus, the basic scientific evidence for anti-aging effects of LBPs is already available. However, additional studies are needed to understand mechanisms by which LBPs mediate anti-aging properties. Novel findings from such studies would likely pave the way for the clinical application of traditional chinese medicine Lycium barbarum in modern evidence-based medicine.

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Phytoestrogens alter the reproductive organ development in the mink (Mustela vison)

Cited by 13 publications

References 34 publications

Effect of Pre-Fixation Delay and Freezing on Mink Testicular Endpoints for Environmental Research

Effect of Pre-Fixation Delay and Freezing on Mink Testicular Endpoints for Environmental Research

Recovery Role of Genistein in Modulating the Alterations in Some Haematological Parameters and Hepatic Antioxidant Enzymes in Gamma Irradiated Mice

Lycium Barbarum: A Traditional Chinese Herb and A Promising Anti-Aging Agent

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