Phytoestrogens and the menopause – do they really help?

Jefferson, Angie

doi:10.1111/j.1467-3010.2005.00506.x

Cited by 4 publications

(6 citation statements)

References 11 publications

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“…[2][3][4][5] In one study, knowledge regarding the menopause and its treatment was reported to be lower among women with lower income groups. 6 It is commonly believed that many adverse climacteric symptoms can be avoided if woman and her family are sufficiently informed about the menopause and its management.7 Both women in midlife and health professionals believe that attitudes play a role in the experience of menopause, 8 with results from three longitudinal studies supporting this belief.9-11 However, the majority of studies have been conducted among Western, predominantly Caucasian, women. It is documented in several studies that the attitudes of Asian women are different from the western women towards the menopause as Asian women feel themselves psychologically uplifted and more respectful in the society after attaining the menopause.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Knowledge, attitudes and perceptions towards menopause among highly educated Asian women in their midlife

2014

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Usage of any items from the University of Cumbria's institutional repository 'Insight' must conform to the following fair usage guidelines.Any item and its associated metadata held in the University of Cumbria's institutional repository Insight (unless stated otherwise on the metadata record) may be copied, displayed or performed, and stored in line with the JISC fair dealing guidelines (available here) for educational and not-for-profit activities provided that• the authors, title and full bibliographic details of the item are cited clearly when any part of the work is referred to verbally or in the written form• a hyperlink/URL to the original Insight record of that item is included in any citations of the work • the content is not changed in any way• all files required for usage of the item are kept together with the main item file. You may not• sell any part of an item• refer to any part of an item without citation • amend any item or contextualise it in a way that will impugn the creator's reputation• remove or alter the copyright statement on an item.The full policy can be found here. Alternatively contact the University of Cumbria Repository Editor by emailing insight@cumbria.ac.uk.Knowledge, attitudes and perceptions towards menopause among highly educated Asian women in their midlifeFouzia R Memon, Leon Jonker and Roshan A Qazi Abstract Objective: To determine knowledge levels, and attitudes and perceptions towards, menopause among highly educated Asian women in their midlife.Study design: A cross-sectional survey.Setting: Five teaching institutions in Hyderabad, Pakistan.Population: In total, 200 out of 225 (89% response rate) teachers, lecturers and professors, aged 40-59 years, were surveyed in 2013 using a self-administered questionnaire.Results: The mean age of responders was 48 years. Premenopausal and perimenopausal women attributed for 58%, whereas 42% were postmenopausal. All women had a masters degree; 15% had a PhD degree. Forty-six percent of responders thought they had sufficient knowledge about the menopause and 87% had positive perceptions about it, with 76% feeling life was easier and calmer as a result of it. Reported negative perceptions included 30% of women experiencing feelings of grumpiness, irritability, altered work capability and loss of femininity. Health professionals were an information resource. of 60% of cases, only 5% of participants knew about hormone replacement therapy and none knew about available alternative therapies.Conclusion: Despite the fact that the majority of women felt well informed and exhibited a positive attitude towards menopause, a strong urge for more knowledge was expressed. Public health care systems should mobilize resources and take easures to i pro e o e 's a are ess a d knowledge about menopause-related changes through a variety of educational tools and media, including the Internet. A recommendation would be for physicians to provide more information about menopausal symptoms and also therapies to alleviate these symptoms, regardless of the patie...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Knowledge, attitudes and perceptions towards menopause among highly educated Asian women in their midlife

2014

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“…Soymilk, a by‐product from soybean manufacture, is increasingly included in western diets. This is in part because the isoflavones in soymilk can bring many benefits to peri‐ and postmenopausal women, including relief from hot flushes (Jefferson 2005), improved lipid profiles, protection against oxidative damage to DNA (Ryan‐Borchers and others 2006), and maintenance of bone health (Setchell and Lydeking‐Olsen 2003; Atkinson and others 2004; Lydeking‐Olsen and others 2004). …”

Section: Introductionmentioning

confidence: 99%

Fermentation of Calcium‐Fortified Soymilk with Lactobacillus: Effects on Calcium Solubility, Isoflavone Conversion, and Production of Organic Acids

Tang

Shah

Wilcox

et al. 2007

Journal of Food Science

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The objective of this study was to enhance calcium solubility and bioavailability from calcium-fortified soymilk by fermentation with 7 strains of Lactobacillus, namely, L. acidophilus ATCC 4962, ATCC33200, ATCC 4356, ATCC 4461, L. casei ASCC 290, L. plantarum ASCC 276, and L. fermentum VRI-003. The parameters that were used are viability, pH, calcium solubility, organic acid, and biologically active isoflavone aglycone content. Calcium-fortified soymilk made from soy protein isolate was inoculated with these probiotic strains, incubated for 24 h at 37 degrees C, then stored for 14 d at 4 degrees C. Soluble calcium was measured using atomic absorption spectrophotometry (AA). Organic acids and bioactive isoflavone aglycones, including diadzein, genistein, and glycetein, were measured using HPLC. Viability of the strains in the fermented calcium-fortified soymilk was > 8.5 log(10) CFU/g after 24 h fermentation and this was maintained for 14-d storage at 4 degrees C. After 24 h, there was a significant increase (P < 0.05) in soluble calcium. L. acidophilus ATCC 4962 and L. casei ASCC 290 demonstrated the highest increase with 89.3% and 87.0% soluble calcium after 24 h, respectively. The increase in calcium solubility observed was related to lowered pH associated with production of lactic and acetic acids. Fermentation significantly increased (P < 0.05) the level of conversion of isoflavones into biologically active aglycones, including diadzein, genistein, and glycetein. Our results show that fermenting calcium-fortified soymilk with the selected probiotics can potentially enhance the calcium bioavailability of calcium-fortified soymilk due to increased calcium solubility and bioactive isoflavone aglycone enrichment.

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“…However, further studies to validate the efficacy of constituents from these species in hormone replacement therapy are necessary. 9 We previously reported on the isolation of isoflavones from Dipteryx odorata 10,11 and also on the isolation of ergostan-secosteroids (physalins) from P. angulata. 12 In this work, phytochemical procedures using LC-MS 2 and GC-MS techniques to analyze an acetate fraction from C. esculenta crude methanol tuber extract, allowed the detection of glycosylated flavonoids and steroids capable of acting as estrogen-like compounds.…”

Section: Impact Statementmentioning

confidence: 99%

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

Rodrigues

Moreira

Rossete

et al. 2018

Exp Biol Med (Maywood)

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Plant species with recognized estrogenic activity and widely used by Brazil’s female population to prevent the unpleasant symptoms of menopause were investigated in this work to demonstrate if constituents of taro-inhame ( Colocasia esculenta), cumaru ( Dipteryx odorata), and camapu ( Physalis angulata) have the ability to mimic or interfere with the action of estrogens. Moreover, their potential use as natural sources of estrogen-like substances for hormone replacement therapy was evaluated. (a) In vivo pharmacological assays were conducted to determine the estrogenic effects of D. odorata isoflavone-rich extract, P. angulata physalin-rich extract, and C. esculenta flavonoid glycoside-rich fraction (FG) on endocrine glands and reproductive organs of female rats at three different stages of the life cycle. The protocols consisted of uterotrophic assays and cytological evaluation of vaginal smears to detect mucosa cell alterations correlated with changes in hormone levels in each phase of the estrous cycle of female rats. The results indicated that C. esculenta FG exhibited estrogenic activity in prepubescent, pubescent, and adult ovariectomized female rats, while D. odorata isoflavones only promoted a weight increase in the pituitary gland of prepubescent rats after prolonged treatment and P. angulata physalins induced a weight increment in the adrenal glands of ovariectomized rats. Additionally, C. esculenta exerted a significant effect on the opening of the vaginal canal in prepubescent rats and on vaginal epithelium. Prolonged treatment of ovariectomized rats with FG altered the proportion of different types of vaginal epithelial cells in these animals, suggesting an interference of FG with estrogen levels. Colocasia esculenta FG induced hypertrophy of the uterus and pituitary in ovariectomized rats similar to estradiol. To elucidate the mechanism of action of FG, its effects were compared to those of estradiol and of the selective estrogen receptor modulator raloxifene. The results suggest that the efficacy of C. esculenta FG is mediated by binding to selective estrogen receptors present in each organ and that raloxifene inhibits the mechanism of action of FG in the same way as it inhibits the effects of estradiol. The overall findings indicate that C. esculenta FG mimics the action of estrogens, with reduced harmful effects on specific tissues. Impact statement The results of this work provide preliminary evidence that ovariectomized rats display the vaginal smear cells typical of the estrous phase of mature rats after long-term ingestion of Colocasia esculenta flavonoid glycosides. Moreover, the treatment caused beneficial effects on endocrine and reproductive organs compared to estradiol. The animals did not exhibit significant body weight alterations among the groups, demonstrating the maintenance of standard metabolism and energy balance. The overall findings obtained with the rat model of menopause highlight the importance of dietary consumption of C. esculenta constituents as potential selective estrogen receptor modulators and suggest that they may prevent some of the metabolic disorders related to estrogen deficiency.

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Phytoestrogens and the menopause – do they really help?

Cited by 4 publications

References 11 publications

Knowledge, attitudes and perceptions towards menopause among highly educated Asian women in their midlife

Knowledge, attitudes and perceptions towards menopause among highly educated Asian women in their midlife

Fermentation of Calcium‐Fortified Soymilk with Lactobacillus: Effects on Calcium Solubility, Isoflavone Conversion, and Production of Organic Acids

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

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