Phytoestrogens for menopausal vasomotor symptoms

Lethaby, Anne; Marjoribanks, Jane; Kronenberg, Fredi; Roberts, Helen; Eden, John; Brown, Julie

doi:10.1002/14651858.cd001395.pub4

Cited by 177 publications

(178 citation statements)

References 165 publications

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“…Probably the lack of information and knowledge of HT and its risks and benefits lead the women to try other therapies such as natural remedies, herbs and food supplement since they consider these treatments safer. Recent metaanalyses show positive evidence that phytoestrogens are effective in alleviating menopausal symptoms, but more studies are needed (39,40). According to a systematic review, herbal preparations containing black cohosh cause a reduction in menopausal symptoms by 26%; but there were significant differences between trials (41).…”

Section: Discussionmentioning

confidence: 99%

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

et al. 2014

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Objectives The use of hormone therapy (HT) for hot flushes has changed dramatically over the past five decades.In this cross-sectional questionnaire study, the aim was to describe the use of HT and alternative treatments and to study the frequency of hot flushes. A further aim was to compare data from the present questionnaire with data from previous studies made in the same geographic area.Method A questionnaire was sent to a random sample of 2,000 women aged 47-56 years living in Östergötland County, Sweden. The results were compared with findings from previous studies regarding use of HT, alternative treatment and hot flushes, and the number of HT prescriptions dispensed during the corresponding time using data derived from the Swedish Prescribed Drug Registry. ResultsThe response rate was 66%. Six percent used HT, in line with prevalence data from the Swedish Prescribed Drug Registry. Alternative treatments were used by 10%. About 70% of postmenopausal women reported flushes and almost one third of those with flushes stated that they would be positive to HT if therapy could be shown to be harmless, a view more often stated by women with severe complaints of hot flushes (67%). ConclusionThe use of HT and alternative treatments is low and many women suffer from flushes that could be treated. Women considered their knowledge of the climacteric period and treatment options as insufficient. Individualized information should be given and women with significant climacteric complaints, without contraindications, should be given the opportunity to try HT.3

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Section: Discussionmentioning

confidence: 99%

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

et al. 2014

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“…A strong placebo efect was noted in most trials, with a reduction in frequency ranging from 1 to 59% with placebo. Discrepant results could be related to the amount of isolavone in the active treatment arm, the severity of vasomotor symptoms or trial quality factors [49].…”

Section: Clinical Studiesmentioning

confidence: 99%

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Estrada‐Camarena¹,

López‐Rubalcava²,

Sustaita³

et al. 2017

A Multidisciplinary Look at Menopause

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Menopause transition is recognized as a vulnerable period in women life to develop or aggravate symptoms of psychiatric disorders. Several treatments including antidepressants and hormonal restitution with estrogens have been suggested to ameliorate the symptoms. Also, in this period of life is frequent the use of other drugs to treat is also frequent the use of other drugs to treat comorbid pathologies that might even increase the risk of drug-drug interactions. Literature reports that some phytochemicals with estrogenic activity have beneicial efects during menopausal transition without collateral events. This chapter shows evidence about the use of phytoestrogens as an alternative therapy for the treatment of some psychiatric symptoms associated with the menopausal transition. Data derived from preclinical research related to the use of classical phytoestrogens (isolavones), considering the beneicial efects, as well as adverse events, are discussed. Also, the use of polyphenols and organosulfurate compounds as an alternative for the treatment of anxiety-and depressive-like behavior as well as ibromyalgia is included. A narrative review was conducted using bibliography reporting the use of isolavones (genistein, daidzein, equol), coumestans or lignans for the reduction of depressive-like or anxiety-like behavior. Furthermore, it is described if the use of this compounds impact in other signs of menopause, i.e. vasomotor and osteoporosis. In addition, due to the high frequency of comorbid pathologies as diabetes mellitus, dyslipidemia or metabolic syndrome with psychiatric disorders, the use of these phytochemicals is discussed.

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“…Daidzein is also found to dilate arteries via the inhibition of Ca 2+ inflow (Torregrosa et al, 2003). As a phytoestrogen, daidzein acts either as an estrogen agonist or as an antagonist, and thus used for natural estrogen replacement therapy (Lethaby et al, 2007;Setchell & Cassidy, 1999). Estrogen is found to relax duodenum in an estrogen receptor-independent way and to dramatically improve the stool scores of HLA-B27 transgenic rats with chronic diarrhea (Setchell & Cassidy, 1999;Harnish et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of daidzein on intestinal motility in normal and high contractile states

Chen

Xiong

Tang

et al. 2012

Pharmaceutical Biology

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Phytoestrogens for menopausal vasomotor symptoms

Cited by 177 publications

References 165 publications

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

Hot flushes, hormone therapy and alternative treatments: 30 years of experience from Sweden

Use of Phytoestrogens for the Treatment of Psychiatric Symptoms Associated with Menopause Transition

Inhibitory effects of daidzein on intestinal motility in normal and high contractile states

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