Phytofabrication and characterization of Alchornea cordifolia silver nanoparticles and evaluation of antiplasmodial, hemocompatibility and larvicidal potential

Foko, Loick Pradel Kojom; Hawadak, Joseph; Verma, Vaishali; Kedi, Philippe Belle Ebanda; Moukoko, Carole Else Eboumbou; Raghavendra, Kamaraju; Pande, Veena; Singh, Vineeta

doi:10.3389/fbioe.2023.1109841

Cited by 4 publications

(6 citation statements)

References 80 publications

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“…Biologically synthesized AgNPs using the leaf extract of Alchornea cordifolia were of size 11.77 ± 5.57 nm, spheroidal, and polycrystalline, and they showed high levels of antiplasmodial activity against 3D7 and RKL9 Plasmodium falciparum strains. This was due to their small size and high surface area to volume ratio, which facilitates their potential to penetrate cell membranes ( Kojom Foko et al, 2023 ). According to the findings of one study, the crude extracts of Azadirachta indica exhibited dose-dependent antiplasmodial activity ( Hawadak et al, 2022 ).…”

Section: Medicinal Properties Of Silver Nanoparticlesmentioning

confidence: 99%

Plant-mediated synthesis of silver nanoparticles: unlocking their pharmacological potential–a comprehensive review

Dhir,

Chauhan,

Subham

et al. 2024

Front. Bioeng. Biotechnol.

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In recent times, nanoparticles have experienced a significant upsurge in popularity, primarily owing to their minute size and their remarkable ability to modify physical, chemical, and biological properties. This burgeoning interest can be attributed to the expanding array of biomedical applications where nanoparticles find utility. These nanoparticles, typically ranging in size from 10 to 100 nm, exhibit diverse shapes, such as spherical, discoidal, and cylindrical configurations. These variations are not solely influenced by the manufacturing processes but are also intricately linked to interactions with surrounding stabilizing agents and initiators. Nanoparticles can be synthesized through physical or chemical methods, yet the biological approach emerges as the most sustainable and eco-friendly alternative among the three. Among the various nanoparticle types, silver nanoparticles have emerged as the most encountered and widely utilized due to their exceptional properties. What makes the synthesis of silver nanoparticles even more appealing is the application of plant-derived sources as reducing agents. This approach not only proves to be cost-effective but also significantly reduces the synthesis time. Notably, silver nanoparticles produced through plant-mediated processes have garnered considerable attention in recent years due to their notable medicinal capabilities. This comprehensive review primarily delves into the diverse medicinal attributes of silver nanoparticles synthesized using plant-mediated techniques. Encompassing antimicrobial properties, cytotoxicity, wound healing, larvicidal effects, anti-angiogenesis activity, antioxidant potential, and antiplasmodial activity, the paper extensively covers these multifaceted roles. Additionally, an endeavor is made to provide an elucidated summary of the operational mechanisms underlying the pharmacological actions of silver nanoparticles.

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Section: Medicinal Properties Of Silver Nanoparticlesmentioning

confidence: 99%

Plant-mediated synthesis of silver nanoparticles: unlocking their pharmacological potential–a comprehensive review

Dhir,

Chauhan,

Subham

et al. 2024

Front. Bioeng. Biotechnol.

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“…The nanoparticle sizes are according to transmission electron microscopy (TEM) or scanning electron microscopy (SEM) analysis. Plant Extract Plant Use Type of Nanotechnology Size of Nanoparticles Effects References Alchornea cordifolia leaf Infections, inflammation, rheumatism, analgesia, and arthritis Ag NPs 5–25 nm (TEM) Larvicidal, impact on larvae behavior and morphology, antiplasmodial and hemolytic [ 109 ] Aristolochia indica leaf Post–partum infections, snakebites, fever, malaria, skin diseases, helminths, edema, intestinal disorders, and antibacterial Ag NPs 30–55 nm (SEM) Larvicidal and pupicidal in laboratory and field, predation booster [ 110 ] Azadirachta indica leaf and bark Antimalarial, intestinal disorders, and diabetes Ag NPs 4–28 nm (TEM) Antiplasmodial and hemolytic [ 41 ] Cedrus deodara oil Insecticidal Pectin nanocapsules 40–80 nm (TEM) Larvicidal and impact on larvae behavior and morphology [ 111 ] Cocos nucifera mesocarp Food Ag NPs mean 23 nm (TEM) Larvicidal …”

Section: Malaria Prevention Strategiesmentioning

confidence: 99%

“…Exposure to Ag NPs synthesized with Alchornea cordifolia leaf extract triggered behavioral and morphological changes in larvae, with reduced swimming [ 109 ]. L. siceraria ZnO NPs caused the loss of body hair, the decomposition of the outer cuticle’s epithelial layer, and the disintegration of abdominal structures and midgut on A. stephensi third instar larvae [ 99 ].…”

Section: Plant Extracts and Green Nps Action Mechanismsmentioning

confidence: 99%

“…In the same study, larval mortality of A. aegypti was also assessed and proven to be lower because a 100% mortality rate was seen for the first instar larvae of A. stephensi but not A. aegypti [ 98 ]. Likewise, A. cordifolia Ag NPs were more lethal to A. stephensi larvae than other mosquito species [ 109 ]. Conversely, Annona squamosa Ag NPs LC50 values were higher for A. stephensi than A. aegypti and C. quinquefasciatus [ 122 ].…”

Section: Antimalarial Effects Of Green Npsmentioning

confidence: 99%

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Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Moraes-de-Souza,

de Moraes,

Silva

et al. 2024

Pharmaceutics

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Malaria poses a global threat to human health, with millions of cases and thousands of deaths each year, mainly affecting developing countries in tropical and subtropical regions. Malaria’s causative agent is Plasmodium species, generally transmitted in the hematophagous act of female Anopheles sp. mosquitoes. The main approaches to fighting malaria are eliminating the parasite through drug treatments and preventing transmission with vector control. However, vector and parasite resistance to current strategies set a challenge. In response to the loss of drug efficacy and the environmental impact of pesticides, the focus shifted to the search for biocompatible products that could be antimalarial. Plant derivatives have a millennial application in traditional medicine, including the treatment of malaria, and show toxic effects towards the parasite and the mosquito, aside from being accessible and affordable. Its disadvantage lies in the type of administration because green chemical compounds rapidly degrade. The nanoformulation of these compounds can improve bioavailability, solubility, and efficacy. Thus, the nanotechnology-based development of plant products represents a relevant tool in the fight against malaria. We aim to review the effects of nanoparticles synthesized with plant extracts on Anopheles and Plasmodium while outlining the nanotechnology green synthesis and current malaria prevention strategies.

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“…Moreover, artemisinin-based combination therapy (ACT) effectively treats mild malaria by targeting molecular markers and studying resistance genetics for improved results [146]. On this basis, Foko et al [89] optimized and characterized the green synthesis of Ag-NPs using A. cordifolia leaves for potential medical uses. These polycrystalline, stable spheres showed strong antiplasmodial action against P. falciparum strains, making them safe for blood use.…”

Section: Inorganic Nmsmentioning

confidence: 99%

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

Sadiq,

Khan,

Shen

et al. 2023

Molecules

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Pathogens cause infections and millions of deaths globally, while antipathogens are drugs or treatments designed to combat them. To date, multifunctional nanomaterials (NMs), such as organic, inorganic, and nanocomposites, have attracted significant attention by transforming antipathogen livelihoods. They are very small in size so can quickly pass through the walls of bacterial, fungal, or parasitic cells and viral particles to perform their antipathogenic activity. They are more reactive and have a high band gap, making them more effective than traditional medications. Moreover, due to some pathogen’s resistance to currently available medications, the antipathogen performance of NMs is becoming crucial. Additionally, due to their prospective properties and administration methods, NMs are eventually chosen for cutting-edge applications and therapies, including drug administration and diagnostic tools for antipathogens. Herein, NMs have significant characteristics that can facilitate identifying and eliminating pathogens in real-time. This mini-review analyzes multifunctional NMs as antimicrobial tools and investigates their mode of action. We also discussed the challenges that need to be solved for the utilization of NMs as antipathogens.

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Phytofabrication and characterization of Alchornea cordifolia silver nanoparticles and evaluation of antiplasmodial, hemocompatibility and larvicidal potential

Cited by 4 publications

References 80 publications

Plant-mediated synthesis of silver nanoparticles: unlocking their pharmacological potential–a comprehensive review

Plant-mediated synthesis of silver nanoparticles: unlocking their pharmacological potential–a comprehensive review

Tiny Green Army: Fighting Malaria with Plants and Nanotechnology

Recent Updates on Multifunctional Nanomaterials as Antipathogens in Humans and Livestock: Classification, Application, Mode of Action, and Challenges

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