Phytofabrication of cobalt oxide nanoparticles from <i>Rhamnus virgata</i> leaves extract and investigation of different bioactivities

Abbasi, Banzeer Ahsan; Iqbal, Javed; Khan, Zaibunisa; Ahmad, Riaz; Uddin, Siraj; Shahbaz, Amir; Zahra, Syeda Anber; Shaukat, Muzaffar; Kiran, Farmeen; Kanwal, Sobia; Mahmood, Tariq

doi:10.1002/jemt.23577

Cited by 45 publications

(26 citation statements)

References 47 publications

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“…However, the mechanism through which ZnO-NP is capable of conferring partly differential responses remains controversial. A majority of researchers believe that differential physicochemical characteristics of nanoparticles relative to the bulk contributed to differences in their uptake kinetics, subsequent interactions with biomolecules, signaling, and responses [1][2][3][10][11][12]22,27,28]. More studies are, therefore, required to confirm this hypothesis.…”

Section: Plos Onementioning

confidence: 99%

“…Nowadays, nanotechnology provides great opportunities for development in a plethora of disciplines, including biotechnology and agriculture [1][2][3]. Taking account of agriculture's requirements, attempts have been made to enhance crop productivity and fruit quality, to improve immunity, and to reduce the consumption of chemical fertilizers/pesticides [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Zinc oxide nanoparticles mediated substantial physiological and molecular changes in tomato

et al. 2021

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There has long been debate about how nanoproducts meet agricultural requirements. This study aimed to investigate tomato responses to the long-time foliar application of zinc oxide nanoparticles (ZnO-NP; 0 and 3 mgl-1) or bulk type (BZnO). Both ZnO-NP and BZnO treatments, especially the nanoform, were significantly capable of improving growth, biomass, and yield. The ZnO-NP treatment upregulated the expression of the R2R3MYB transcription factor by 2.6 folds. The BZnO and ZnO-NP treatments transcriptionally up-regulated WRKY1 gene by 2.5 and 6.4 folds, respectively. The bHLH gene was also upregulated in response to BZnO (2.3-fold) or ZnO-NP (4.7-fold). Moreover, the ZnO-NP application made a contribution to upregulation in the EREB gene whereas the bulk compound did not make a significant change. Upregulation in the HsfA1a gene also resulted from the ZnO-NP (2.8-fold) or BZnO (1.6-fold) supplementation. The MKK2 and CAT genes displayed a similar upregulation trend in response to the supplements by an average of 3-folds. While the application of ZnO-NP slightly down-regulated the histone deacetylases (HDA3) gene by 1.9-fold, indicating epigenetic modification. The supplements, especially the nano-product, enhanced concentrations of K, Fe, and Zn in both leaves and fruits. The concentrations of Chla, Chlb, and carotenoids were increased in response to the BZnO or ZnO-NP treatments. Likewise, BZnO or ZnO-NP mediated an increase in activity of nitrate reductase and proline content in leaves. These treatments increased soluble phenols and phenylalanine ammonia-lyase activity. With a similar trend, the BZnO or ZnO-NP application improved the activities of catalase and peroxidase enzymes. The reinforcement in metaxylem and secondary tissues resulted from the applied supplements. This study provides comprehensive comparative evidence on how ZnO-NPs may remodel the chromatin ultrastructure and transcription program, and confer stress tolerance in crops. This study also underlines the necessity of providing integrated transcriptome and proteome data in future studies.

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Section: Plos Onementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zinc oxide nanoparticles mediated substantial physiological and molecular changes in tomato

et al. 2021

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“…Similarly, cobalt oxide nanoparticles might also play important roles in human health, thus showing potential for a variety of biomedical applications. In some infectious diseases, cobalt oxide nanoparticles exert powerful anti-infective capabilities, indicating their potential to act as antibacterial, antifungal and anti-parasite agents [18,19].…”

Section: Introductionmentioning

confidence: 99%

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

et al. 2021

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Cobalt is essential to the metabolism of all animals due to its key role in cobalamin, also known as vitamin B12, the primary biological reservoir of cobalt as an ultra-trace element. Current cancer treatment strategies, including chemotherapy and radiotherapy, have been seriously restricted by their side effects and low efficiency for a long time, which urges us to develop new technologies for more effective and much safer anticancer therapies. Novel nanotechnologies, based on different kinds of functional nanomaterials, have been proved to act as effective and promising strategies for anticancer treatment. Based on the important biological roles of cobalt, cobalt oxide nanoparticles (NPs) have been widely developed for their attractive biomedical applications, especially their potential for anticancer treatments due to their selective inhibition of cancer cells. Thus, more and more attention has been attracted to the preparation, characterization and anticancer investigation of cobalt oxide nanoparticles in recent years, which is expected to introduce novel anticancer treatment strategies. In this review, we summarize the synthesis methods of cobalt oxide nanoparticles to discuss the advantages and restrictions for their preparation. Moreover, we emphatically discuss the anticancer functions of cobalt oxide nanoparticles as well as their underlying mechanisms to promote the development of cobalt oxide nanoparticles for anticancer treatments, which might finally benefit the current anticancer therapeutics based on functional cobalt oxide nanoparticles.

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“…Different naturally occurring phytochemicals (alkaloids, flavonoids, lignans, saponins, terpenes, taxanes, vitamins, glycosides, oils, and biomolecules) (Iqbal, Abbasi, Ahmad, Ali, et al, 2018; Iqbal, Abbasi, Batool, et al, 2018; Iqbal, Abbasi, Ahmad, Kanwal, et al, 2018; Iqbal, Abbasi, Khalil, et al, 2018; Iqbal, Abbasi, Ahmad, et al, 2020; Iqbal, Abbasi, Munir, et al, 2020) have been isolated from medicinal plants and are used for the treatment of different diseases in the form of drugs and nanoparticles (Abbasi et al, 2018; Abbasi et al, 2019; Abbasi et al, 2021; Iqbal, Abbasi, Ahmad, et al, 2020; Iqbal, Abbasi, Munir, et al, 2020). Phytochemicals are naturally occurring bioactive compounds in plants.…”

Section: Introductionmentioning

confidence: 99%

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

Zahra

Iqbal

Abbasi

et al. 2021

Microscopy Res & Technique

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Sophora alopecuroides L. is a highly medicinal plant. The aim of the current study was to determine the phytochemical screening, pharmacological potentials and application of scanning electron microscope (SEM) of S. alopecuroides (SA) seeds. To achieve this purpose, six different solvents were used to prepare SA seed extracts. Phytochemical and antioxidant activities were determined calorimetrically. To investigate the antidiabetic activity, α-amylase inhibition assay was determined. Brine shrimp assay was used to determine cytotoxicity potential. Anti-leishmanial potential was confirmed using MTT assay. Disc-diffusion method was used to detect protein kinase inhibitory, antibacterial and antifungal activities and showed significant results. SEM analysis was used as an identification tool. Considerable amount of phenolic and flavonoid contents were identified in methanol extract (SASM) (93.76 ± 2.71 GAE/mg) and (77 ± 3.60 QE/mg). Highest DPPH scavenging potential (82%) was reported for SASM. Significant total antioxidant capacity (90.60 ± 1.55 alpha amylase enzyme [AAE]/mg) and total reducing power (94.44 ± 1.38 AAE/mg) were determined for LOSM. Highest α-amylase inhibition was reported in SASM (78.20 ± 1.58%). Highest LD 50 of brine shrimp was found for n-hexane extract (SASH) 13.03 μg/ml. All extracts showed strong anti-leishmanial activity except SASH. The seeds of SA were seen to be oblong to obovate, projections, wavy slightly straight, anticlinal wall was raised with apex acuminate. In conclusion, our experimental findings highly support the ethnomedicinal and biological potentials of the SA seeds. Moreover, SA seeds need to be explored for identification and isolation of bioactive compounds. In future, we recommend further in vivo toxicity assays and clinical efficacies to further evaluate its different biomedical properties.

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Phytofabrication of cobalt oxide nanoparticles from Rhamnus virgata leaves extract and investigation of different bioactivities

Cited by 45 publications

References 47 publications

Zinc oxide nanoparticles mediated substantial physiological and molecular changes in tomato

Zinc oxide nanoparticles mediated substantial physiological and molecular changes in tomato

Inspirations of Cobalt Oxide Nanoparticle Based Anticancer Therapeutics

Scanning electron microscopy of Sophora alopecuroides L. seeds and their cytotoxic, antimicrobial, antioxidant, and enzyme inhibition potentials

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