Phytol directly activates peroxisome proliferator-activated receptor α (PPARα) and regulates gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes

γ-Mangostin fromGarcinia MangostanaPericarps as a Dual Agonist That Activates Both PPARα and PPARδ

“…These cells are wellcharacterized hepatocytes that are used for a gene expression analysis that depends on transfected PPAR activation. 15) Figure 7 shows that the acyl-CoA synthase and CPT1A expression levels were increased with 50 mM bezafibrate. Like bezafibrate, the addition of 5 and 2.5 mM -mangostin significantly induced acyl-CoA synthase and CPT1A expression.…”

DHA attenuates postprandial hyperlipidemia via activating PPARα in intestinal epithelial cells

“…Luciferase assays were performed using the modifi ed dual luciferase system as previously described ( 21 ). Briefl y, for luciferase assays using the GAL4/PPAR chimera system, CV-1 cells or Caco-2 cells were transfected with p4xUASg-tk-luc (reporter plasmid), pM-h PPAR ␣ (chimeric plasmid expressing GAL4 DNA binding domain and human PPAR ␣ -ligand binding domain), pM-h PPAR ␥ or pM-h PPAR ␦ , and pRL-CMV (internal control plasmid for normalizing transfection effi ciencies).…”

Gas Chromatographic-Mass Spectrometric Analysis of Essential Oil of <i>Jasminum officinale</i> L var Grandiflorum Flower

“…Acute administration of phytol exerts an anxiolytic-like effect on mice by producing sedative and anxiolytic activities [11]. Phytol also directly activates peroxisome proliferator-activated receptor α (PPARα) and regulated gene expression involved in lipid metabolism in PPARα-expressing HepG2 hepatocytes [12]. Furthermore, trans-phytol inhibits the biosynthesis of estrogen in human ovarian granulose cells by aromatase (CYP19) [13].…”