Phytol shows anti-angiogenic activity and induces apoptosis in A549 cells by depolarizing the mitochondrial membrane potential

Sakthivel, Ravi; Malar, Dicson Sheeja; Devi, Kasi Pandima

doi:10.1016/j.biopha.2018.06.035

Cited by 94 publications

(46 citation statements)

References 29 publications

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“…The reported necrosis was associated with the augmented production of reactive oxygen cell species (ROSs). Studies performed by Sakthivel, Malar, and Devi corroborated with the apoptotic activity of phytol in A549 cells by a similar mechanism to that described above [ 25 ]. Nevertheless, the mechanism by which terpenes work as antimicrobial agent against bacteria and fungi has not yet been fully described.…”

Section: Introductionsupporting

confidence: 74%

“…This experiment was performed for evaluating in vitro biocompatibility of free-drug SLN and understanding how the phytol changed this property. In addition, the cytotoxic effect of phytol was previously reported in the literature [ 24 , 25 ], and the possible enhancement of this biological effect reinforced the ability of the nanocarrier to improve the phytol interaction with cells.…”

Section: Resultsmentioning

confidence: 65%

“…Phytol(3,7,11,15-tetramethylhexadec-2-EN-1-OL), a branched long chain unsaturated diterpene member found abundantly in nature, is a product of the metabolism of chlorophyll in plants [ 21 , 22 ]. In the literature it was found that phytol exhibits a wide range of bioactivities including antioxidant [ 23 , 24 ], apoptosis-inducing and anti-angiogenic [ 25 ], and antimicrobial/antifungal activities [ 22 , 26 ]. Despite this good biological activity, phytol presents limitations as its solubility in aqueous solution, such as biological fluids, due to being a highly hydrophobic compound [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

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Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

et al. 2020

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Phytol is a diterpene alcohol and can be found as a product of the metabolism of chlorophyll in plants. This compound has been explored as a potential antimicrobial agent, but it is insoluble in water. In this study, we describe a novel approach for an interesting anticandidal drug delivery system containing phytol. Different formulations of phytol-loaded solid lipid nanoparticles (SLN) were designed and tested using a natural lipid, 1,3-distearyl-2-oleyl-glycerol (TG1). Different compositions were considered to obtain three formulations with 1:10, 1:5, and 1:3 w/w phytol/TG1 ratios. All the formulations were prepared by emulsification solvent evaporation method and had their physicochemical properties assessed. The biocompatibility assay was performed in the HEK-293 cell line and the antifungal efficacy was demonstrated in different strains of Candida ssp., including different clinical isolates. Spherical and uniform SLN (<300 nm, PdI < 0.2) with phytol-loading efficiency >65% were achieved. Phytol-loaded SLN showed a dose-dependent cytotoxic effect in the HEK-293 cell line. The three tested formulations of phytol-loaded SLN considerably enhanced the minimal inhibitory concentration of phytol against 15 strains of Candida spp. Considering the clinical isolates, the formulations containing the highest phytol/TG1 ratios showed MICs at 100%. Thus, the feasibility and potential of phytol-loaded SLN was demonstrated in vitro, being a promising nanocarrier for phytol delivery from an anticandidal approach.

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Section: Introductionsupporting

confidence: 74%

Section: Resultsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

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Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

et al. 2020

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“…Although less characterized, a putative antiangiogenic potential for the acyclic diterpenoid phytol, and campesterol and β-sitosterol—two components of sterol fraction of olive oil—has been suggested [91,92,93].…”

Section: Olive Oil As a Source Of Antiangiogenic Moleculesmentioning

confidence: 99%

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer

et al. 2019

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Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention strategy. In this review, we focus on natural bioactive compounds derived from the main foods included in the Mediterranean diet that display anti-angiogenic activity, as well as their possible use as angiopreventive agents.

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“…Opisane są też właściwości przeciwgrzybiczne alkoholu fenyloetylowego, przeciwbakteryjne aromadendrenu, przeciwdrobnoustrojowe, antyoksydacyjne i przeciwzapalne epitlenku izoaromadendrenu, cytotoksyczne 1-okten-3-olu [29]. Fitol znany jest z hamowania proliferacji, indukowania apoptozy, działania antyangiogennego, przeciwzapalnego, antyoksydacyjnego oraz przeciwbakteryjnego [30]. Olejek eteryczny uzyskany z dostępnego na polskim rynku farmaceutycznym G. aparine zawiera liczne składniki o udowodnionej w wielu badaniach, aktywności biologicznej.…”

Section: Analiza Gc/msunclassified

Analysis of essential oil of Galium aparine.

Antoniak¹,

Dudek-Makuch²,

Bylka³

2019

Farm Pol.

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Analysis of essential oil of Galium aparine • Galium aparine L. (clivers, goosegrass) (Rubiaceae) is used in folk medicine as diuretic and medicinal plant alleviating different dermatoses as psoriasis, seborrheic dermatitis, eczema, and improves the immune system. So far, scientific studies have shown as a main constituents: iridoids (mainly asperuloside), flavonoids (luteolin, chrysoeriol, apigenin and quercetin derivatives), numerous of phenolic acids and phytosterols. Previous studies confirmed antimicrobial, antioxidant and cytotoxic activity of clivers. The aim of this work was to investigate the chemical profile of essential oil isolated from G. aparine collected in Poland. The essential oil was extracted from the herb of G. aparine by hydrodistillation in Clevenger-type apparatus and the volatile constituents were identified by gas chromatography coupled with mass spectrometry (GC-MS). 0.1 ml of essential oil (3.33 ml/kg) was obtained from the of G. aparine herb, in which 74 volatile ingredients were identified (100%). According to GC/MS analysis 9-diazo-9H-fluorene (31.93%), palmitic acid and dihomo-γ-linolenic acid (8.89%) were as major constituents. 9-diazo-9H-fluorene is very rare in the plant world, previously identified only in Bidens pilosa. Terpene compounds represented 22.31% of essential oil, including 15 sesquiterpenes (18.23%), 6 monoterpenes (2.00%) and 1 diterpene (3.08%). The other active ingredients of the oil include: phytol, β-ionone, anethole, spatulenol, α-cadinol, phenylethyl alcohol, eugenol, methyleugenol, α-carvacrol, α-caryophyllene, α-terpineol, isoaromadendren epoxide, carvone, linalool, santalol, β-farnesene and eucalyptole. The ingredients of the essential oil are multi-directional activity: anti-inflammatory, antimicrobial, anti-cancer, antiproliferative, effect on angiogenesis, and also have occlusive properties. Quantify and a number of ingredients of the essential oil have proven that it may be one of the bioactive important fractions of G. aparine.

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Phytol shows anti-angiogenic activity and induces apoptosis in A549 cells by depolarizing the mitochondrial membrane potential

Cited by 94 publications

References 29 publications

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

Phytol-Loaded Solid Lipid Nanoparticles as a Novel Anticandidal Nanobiotechnological Approach

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer

Analysis of essential oil of Galium aparine.

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