Phytomedicinal relevance of South African Cucurbitaceae species and their safety assessment: A review

Omokhua-Uyi, Aitebiremen Gift; Staden, J. Van

doi:10.1016/j.jep.2020.112967

Cited by 31 publications

(30 citation statements)

References 56 publications

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“…Cucurbitaceae family, generally known as the cucumber, gourd, melon, or pumpkin family, comprises 120 genera and around 965 species, mainly disseminated in tropical and subtropical regions of the world (Omokhua-Uyi and Van Staden 2020 ). Some of the most important genera of this family are Benincasa , Bryonopsis , Citrullus , Cucumis , Cucurbita , Luffa , Momordica and Trichosanthes (Dhiman et al 2012 ).…”

Section: Introductionmentioning

confidence: 99%

“…Momordica balsamina L., commonly named balsam apple, southern balsam pear or African pumpkin, is native to the African tropical regions, occurring also in Asia, India and Australia. It is also widely found in tropical America, probably as a result of human introduction (Thakur et al 2009 ; Omokhua-Uyi and Van Staden 2020 ). The plant is a monoecious annual or short-lived perennial herb with stems that can reach 5 m long, with simple alternate lobed leaves and tendrils for attachment.…”

Section: Introductionmentioning

confidence: 99%

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Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

et al. 2022

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Momordica balsamina L. (Cucurbitaceae), frequently named balsam apple, southern balsam pear or African pumpkin, is a vegetable with high nutritional value, being mostly used as food in sub-Saharan Africa. It has also been largely used in traditional medicine to treat several diseases, such as malaria fevers and diabetes. As a member of the Cucurbitaceae family, the main constituents are cucurbitane-type triterpenoids, with different oxidation patterns, named cucurbitacins. This review aims at summarizing our contribution to the phytochemical study of M. balsamina and the evaluation of the isolated cucurbitacins and derivatives as multidrug resistance reversers in cancer cells and bacteria. In this way, the selective antiproliferative activity against multidrug resistant cancer cells of cucurbitacins obtained from M. balsamina, their ability as P-glycoprotein inhibitors in cancer cells overexpressing this ABC transporter, as well as efflux pump inhibitors in resistant bacteria strains are reviewed. Moreover, the in vitro antimalarial activity of cucurbitacins and acyl derivatives against the blood and liver-stages of Plasmodium strains, and the in vivo activity of selected compounds is also reviewed. Besides our work, edible and medicinal uses, and other studies mainly reporting the biological activities of M. balsamina extracts, such as antidiabetic, antibacterial, anti-inflammatory, and antioxidant properties are also addressed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

et al. 2022

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“…Fifteen steroids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) were isolated from T. cucumerina, T. cucumeroides, T. japonica, T. kirilowii and T. tricuspidata (Fig. 2) [13][14][15][16][17][18][19][20][21].…”

Section: Steroids and Triterpenoidsmentioning

confidence: 99%

“…Cucurbitaceae plants are widely used in traditional medicines for a variety of ailments, especially in the ayurvedic and Chinese medicines, including treatments against gonorrhoea, ulcers, respiratory diseases, jaundice, syphilis, scabies, constipation, worms, piles, leprosy, skin infections, haemoptysis, diabetes, night-blindness, obesity, kidney and liver diseases [6][7][8]. In modern medicine, the Cucurbitaceae comprises plants of great interest, with a wide range of biological activities including antidiabetic, anti-tumoral, anti-parasitic, anti-bacterial, anti-inflammatory and cytotoxic activities [9].…”

Section: Introductionmentioning

confidence: 99%

Chemical constituents of the genus Trichosanthes (Cucurbitaceae) and their biological activities: A review

Pabuprapap¹,

Suksamrarn²

2021

ScienceAsia

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Trichosanthes is one of the largest genera in the Cucurbitaceae family. It is constantly used in traditional medications to cure diverse human diseases and is also utilized as ingredients in some food recipes. It is enriched with a diversity of phytochemicals and a wide range of biological activities. The major chemical constituents in this plant genus are steroids, triterpenoids and flavonoids. This review covers the different types of chemical constituents and their biological activities from the Trichosanthes plants.

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“…This has multiple anti diabetic properties when consumed as fresh juice or eaten regularly. Side effects reported so far is diarrhea [44,[46][47][48][49][50][51]. Spices used in a wide variety of cuisines around the world like cinnamon (Cinnamomum) and some used in the Indian subcontinent such as fenugreek (Trigonella foenum) are also implicated in controlling hyperglycemia (Figure 2B and C).…”

Section: Nutritional Supplementsmentioning

confidence: 99%

Nutritional Interventions: Diet Modifications, Nutritional Supplements, Complementary and Alternative Medicine

Banu¹

2021

Type 2 Diabetes - From Pathophysiology to Cyber Systems

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Type 2 diabetes (T2DM) is characterized by increased circulating blood glucose levels. Several therapies are available to control glucose levels. However, nutritional choices play a major role in managing diabetes. Nutritional supplements can help in reducing the side effects of medicines on the individual so, this chapter will not only discuss several nutritional choices but also available nutritional supplements to control T2DM. Keeping in mind the traditional belief that food is medicine and as therapies are often associated with deleterious side effects, this chapter will discuss alternative and herbal medicines. In addition, life style alterations with proper nutritional choices is also important and will be touched upon in this chapter.

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Phytomedicinal relevance of South African Cucurbitaceae species and their safety assessment: A review

Cited by 31 publications

References 56 publications

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

Momordica balsamina: phytochemistry and pharmacological potential of a gifted species

Chemical constituents of the genus Trichosanthes (Cucurbitaceae) and their biological activities: A review

Nutritional Interventions: Diet Modifications, Nutritional Supplements, Complementary and Alternative Medicine

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