Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR

Zhao, Qiulong; Liu, Jin; Chen, Li; Gao, Zhao; Lin, Muhai; Wang, Yun; Xiao, Zhe; Chen, Yi; Huang, Xi

doi:10.1016/j.jep.2024.117703

Cited by 3 publications

(2 citation statements)

References 70 publications

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“…Additionally, it was found that FA and MH treatment reversed these BOLD signal changes to varying degrees. 88 Bacopa monnieri was tested for its effects on 5-HT receptors using antagonists of 5-HT 1 , 5-HT 2 , and 5-HT 3 receptors. Furthermore, Bacopa monnieri (80 mg/kg p.o.)…”

Section: ■ Depressionmentioning

confidence: 99%

“…The study revealed the activation of excessive blood oxygen level-dependent (BOLD) signals in specific brain regions, including the left accumbens nucleus, left corpus callosum, and hypothalamus preoptic region, following acute stress stimuli. Additionally, it was found that FA and MH treatment reversed these BOLD signal changes to varying degrees …”

Section: Depressionmentioning

confidence: 99%

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Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Akotkar,

Aswar,

Ganeshpurkar

et al. 2024

ACS Pharmacol. Transl. Sci.

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The 5-hydroxytryptamine-3 receptor (5-HT3R), a subtype of serotonin receptor, is a ligand-gated ion channel crucial in mediating fast synaptic transmission in the central and peripheral nervous systems. This receptor significantly influences various neurological activities, encompassing neurotransmission, mood regulation, and cognitive processing; hence, it may serve as an innovative target for neurological disorders. Multiple studies have revealed promising results regarding the beneficial effects of these phytoconstituents and extracts on conditions such as nausea, vomiting, neuropathic pain depression, anxiety, Alzheimer’s disease, cognition, epilepsy, sleep, and dyskinesia via modulation of 5-HT3R in the pathophysiology of neurological disorder. The review delves into a detailed exploration of in silico, in vitro, and in vivo studies and clinical studies that discussed phytoconstituents acting on 5-HT3R and attenuates difficulties in neurological diseases. The diverse mechanisms by which plant-derived phytoconstituents influence 5-HT3R activity offer exciting avenues for developing innovative therapeutic interventions. Besides producing an agonistic or antagonistic effect, some phytoconstituents exert modulatory effects on 5-HT3R activity through multifaceted mechanisms. These include γ-aminobutyric acid and cholinergic neuronal pathways, interactions with neurokinin (NK)-1, NK2, serotonergic, and γ-aminobutyric acid(GABA)ergic systems, dopaminergic influences, and mediation of calcium ions release and inflammatory cascades. Notably, the phytoconstituent’s capacity to reduce oxidative stress has also emerged as a significant factor contributing to their modulatory role. Despite the promising implications, there is currently a dearth of exploration needed to understand the effect of phytochemicals on the 5-HT3R. Comprehensive preclinical and clinical research is of the utmost importance to broaden our knowledge of the potential therapeutic benefits associated with these substances.

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Section: ■ Depressionmentioning

confidence: 99%

Section: Depressionmentioning

confidence: 99%

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Akotkar,

Aswar,

Ganeshpurkar

et al. 2024

ACS Pharmacol. Transl. Sci.

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A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus

Wu,

Sun,

et al. 2025

Biomedicine & Pharmacotherapy

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Role of Zhiqiao Chuanlian decoction in the treatment of food accumulation fever: Network pharmacology and animal experiments

Zhang,

Cheng

et al. 2024

Heliyon

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Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR

Cited by 3 publications

References 70 publications

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus

Role of Zhiqiao Chuanlian decoction in the treatment of food accumulation fever: Network pharmacology and animal experiments

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Phytomedicine Fructus Aurantii-derived two absorbed compounds unlock antidepressant and prokinetic multi-functions via modulating 5-HT3/GHSR

Cited by 3 publications

References 70 publications

Phytoconstituents Targeting the Serotonin 5-HT3 Receptor: Promising Therapeutic Strategies for Neurological Disorders

Phytoconstituents Targeting the Serotonin 5-HT3 Receptor: Promising Therapeutic Strategies for Neurological Disorders

A rich component of Fructus Aurantii, meranzin hydrate, exerts antidepressant effects via suppressing caspase4 to regulate glial cell and neuronal functions in the hippocampus

Role of Zhiqiao Chuanlian decoction in the treatment of food accumulation fever: Network pharmacology and animal experiments

Contact Info

Product

Resources

About

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders