Phytomedicines as potential inhibitors of β amyloid aggregation: significance to Alzheimer's disease

Metabolic Profiling Provides a System for the Understanding of Alzheimer’s Disease in Rats Post-Treatment With Kaixin San

“…It is now estimated that there are 18-24 million people suffering from AD worldwide, and this number is expected to reach 34 million by 2025 (Scott et al, 2014). Most previous studies have focused on the examination of Ab and Tau in cerebrospinal fluid as markers in AD patients (Kumar and Nisha, 2014). Even worse, at present there are only symptomatic therapies in nature, providing modest improvements in memory, without altering the progression of the disease pathology.…”

(−)-P7C3-S243 Protects a Rat Model of Alzheimer’s Disease From Neuropsychiatric Deficits and Neurodegeneration Without Altering Amyloid Deposition or Reactive Glia

“…The majority of efforts to develop new therapeutics have thus far focused predominantly on targeting early events of neuroinflammation or amyloid pathology that precede neuronal loss in AD (6). Unfortunately, this approach has thus far failed to help patients (8–10). As the AD crisis rapidly escalates, there is an ever-increasing need for disease-modifying treatments.…”

Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs)

“…Basically, rapid progression of NDDs among the elderly population has led to the growing interest in numerous pharmacological approaches aimed at counteracting and arresting neurological malfunction and its devastating effects [ 4 ]. Considering the fact that dementia-related disorders are caused by many factors and that there are no effective medications available for their prevention, efficient intervention strategies using naturally occurring bioactive compounds has, therefore, become the best option [ 5 ]. Interestingly, some efforts have been made in the identification of potential agents capable of alleviating the pathology of these dementia-related disorders, and some of these potential agents are plants’ secondary metabolites known as phytochemicals [ 6 ].…”