Phytomedicines (medicines derived from plants) for sickle cell disease

Oniyangi, Oluseyi; Cohall, Damian

doi:10.1002/14651858.cd004448.pub5

Cited by 15 publications

(8 citation statements)

References 45 publications

(43 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…98 Unfortunately, a true clinical benefit in patients was not proven. 99,100 Similarly, another herbal extract obtained from the plant Cajanus cajan (Ciklavit © ) failed to show an advantage in reducing SCA crises in a RCT. 99,101…”

Section: Herbal Drugsmentioning

confidence: 99%

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment

Piccin

Murphy

Eakins

et al. 2019

European J of Haematology

View full text Add to dashboard Cite

Sickle cell anaemia (SCA) is the consequence of abnormal haemoglobin production due to an inherited point mutation in the β‐globin gene. The resulting haemoglobin tetramer is poorly soluble when deoxygenated, and when this is prolonged, intracellular gelation of sickle haemoglobin occurs, followed by haemoglobin polymerisation. If many cycles of sickling and unsickling occur, the red cell membrane will be disrupted leading to haemolysis and vaso‐occlusive events. Recent studies have also shown that leucocyte adhesion molecules and nitric oxide (NO) depletion are involved in endothelial damage. New insights in SCA pathophysiology and vascular biology have shown that cell‐derived microparticle (MP) generation is also involved in the vaso‐occlusion. Endothelial damage is perpetuated by impaired production or increased consumption of protective modulators such as protein C, protein S and NO. New therapeutic interventions should address these aspects of SCA pathogenesis. To date, the only US‐FDA‐approved therapy to prevent painful vaso‐occulsive episodes is hydroxyurea that reduces haemoglobin polymerisation in sickle cells by increasing the production of foetal haemoglobin and L‐glutamine. However, several new drugs have been tested in the last years in randomised clinical trials. We here report an update on the current status of knowledge on SCA.

show abstract

Section: Herbal Drugsmentioning

confidence: 99%

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment

Piccin

Murphy

Eakins

et al. 2019

European J of Haematology

View full text Add to dashboard Cite

show abstract

“…The migration of potassium and chloride ions carrying water across the RBCs causes dehydration, which consequently increases the tendency of the hemoglobin to polymerize and sickle. Studies show a potential therapeutic solution to reduce the cell sickling by blocking the loss of electrolytes from erythrocytes through two ion transport pathways, namely the K-Cl co -transporter and the Ca2 + -activated K+ channel [ 68 ].…”

Section: Introductionmentioning

confidence: 99%

“…Eugenia caryophyllata and Piper guineense contain vanilloids like Shikimic acid and cannaboids that are of benefit in reducing the painful episodes by mechanisms similar to that of the opiates [ 74 ], F.zanthoxyloides, natively called fagara has been used for the reduction of painful episodes in SCD. Nicosan is a popular and safe Nigerian anti sickling herbal remedy inhibiting hemoglobin S polymerization [ 68 ]. Bioassay experiments show that maximum reduction in sickling was observed by the leaf extracts of C. papaya at concentrations of 5 mg/mL [ 52 ] probably due to relatively high total phenol content exhibiting high free radical scavenging activity.…”

Section: Introductionmentioning

confidence: 99%

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

et al. 2016

View full text Add to dashboard Cite

Nutritional research in sickle cell disease has been the focus in recent times owing to not only specific nutritional deficiencies, but also the improvements associated with less painful episodes. Though hydroxyurea remains the drug of choice, certain adverse health effects on long term supplementation makes room for researches of different compounds. Macro and micro nutrient deficiencies, along with vitamins, play an important role in not only meeting the calorific needs, but also reducing clinical complications and growth abnormalities. Symptoms of hyper protein metabolism, increased cell turnover, increased cardiac output, and appetite suppression due to enhanced cytokine production, might give us leads for better understanding of the mechanisms involved. Different nutritional approaches comprising of traditional herbal therapies, antioxidants, flavonoids, vitamins, minerals etc., reducing oxidative stress and blood aggregation, have been tried out to increase the health potential. Nutritional therapies may also serve complementary to the newer therapies using ozone, hematopoietic stem cell transplantation, antifungal medications, erythropoietin etc. Herein we try to present a holistic picture of the different patho-physiological mechanisms, and nutritional strategies adopted.

show abstract

“…Given the increasing mortality rate of patients with sickle cell disease, especially in children, and the side effects of chemotherapy, the addition of natural products (phytomedicines/herbal drugs) in the treatment is beneficial [187]. Several herbal extracts have properties in sickle cell anemia treatment, but there is still no promising drug on the market for the treatment of this condition [188][189][190][191]. The active constituents of medicinal plants and natural compounds, known as antisickling agents, are rich in aromatic amino acids, phenolic compounds, and antioxidants [192] and acts as antioxidant therapy to ameliorate the complications of sickle cell anemia [193].…”

Section: Natural Antioxidants In the Treatment Of Sickle Cell Anemiamentioning

confidence: 99%

Natural Antioxidants in Anemia Treatment

Cotoraci

Ciceu

Sasu

2021

IJMS

View full text Add to dashboard Cite

Anemia, characterized by a decrease of the hemoglobin level in the blood and a reduction in carrying capacity of oxygen, is a major public health problem which affects people of all ages. The methods used to treat anemia are blood transfusion and oral administration of iron-based supplements, but these treatments are associated with a number of side effects, such as nausea, vomiting, constipation, and stomach pain, which limit its long-term use. In addition, oral iron supplements are poorly absorbed in the intestinal tract, due to overexpression of hepcidin, a peptide hormone that plays a central role in iron homeostasis. In this review, we conducted an analysis of the literature on biologically active compounds and plant extracts used in the treatment of various types of anemia. The purpose of this review is to provide up-to-date information on the use of these compounds and plant extracts, in order to explore their therapeutic potential. The advantage of using them is that they are available from natural resources and can be used as main, alternative, or adjuvant therapies in many diseases, such as various types of anemia.

show abstract

Phytomedicines (medicines derived from plants) for sickle cell disease

Cited by 15 publications

References 45 publications

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment

Insight into the complex pathophysiology of sickle cell anaemia and possible treatment

Precipitating factors and targeted therapies in combating the perils of sickle cell disease--- A special nutritional consideration

Natural Antioxidants in Anemia Treatment

Contact Info

Product

Resources

About