Phytomelatonin content in Valeriana officinalis L. and some related phytotherapeutic supplements

LOSADA, Marta; Caño, Antonio; Hernández‐Ruíz, Josefa; Arnao, Marino B.

doi:10.55484/ijpbp.1079005

Cited by 6 publications

(2 citation statements)

References 44 publications

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“…The effectiveness of valerian ( Valeriana officinalis ) roots as a mild tranquilizer in cases of generalized nervousness, insomnia, restlessness, and moderate anxiety states are well known [ 133 ]. Recently, we measured the phytomelatonin content in natural roots and commercial valerian samples to study the possible contribution of phytomelatonin as a sedative and sleep improvement agent [ 127 ]. Phytomelatonin-rich extracts from valerian roots can be obtained, but the high variability in the phytomelatonin content of raw sources ( Table 2 ) and their limited richness will be a major disadvantage for commercial purposes ( Table 1 , product #9).…”

Section: Strategies To Obtain Biological Melatoninmentioning

confidence: 99%

Melatonin from Microorganisms, Algae, and Plants as Possible Alternatives to Synthetic Melatonin

Arnao

Giraldo-Acosta²,

Castejón-Castillejo³

et al. 2023

Metabolites

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Melatonin dietary supplements are widely consumed worldwide, with developed countries as the largest consumers, with an estimated annual growth rate of approximately 10% until 2027, mainly in developing countries. The wide use of melatonin against sleep disorders and particular problems, such as jet lag, has been added to other applications, such as anti-aging, anti-stress, immune system activation, anticancer, and others, which have triggered its use, normally without a prescription. The chemical industry currently covers 100% of the needs of the melatonin market. Motivated by sectors with more natural consumption habits, a few years ago, the possibility of obtaining melatonin from plants, called phytomelatonin, arose. More recently, the pharmaceutical industry has developed genetically modified microorganisms whose ability to produce biological melatonin in bioreactors has been enhanced. This paper reviews the aspects of the chemical and biological synthesis of melatonin for human consumption, mainly as dietary supplements. The pros and cons of obtaining melatonin from microorganisms and phytomelatonin from plants and algae are analyzed, as well as the advantages of natural melatonin, avoiding unwanted chemical by-products from the chemical synthesis of melatonin. Finally, the economic and quality aspects of these new products, some of which are already marketed, are analyzed.

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Section: Strategies To Obtain Biological Melatoninmentioning

confidence: 99%

Melatonin from Microorganisms, Algae, and Plants as Possible Alternatives to Synthetic Melatonin

Arnao

Giraldo-Acosta²,

Castejón-Castillejo³

et al. 2023

Metabolites

View full text Add to dashboard Cite

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“…It is advisable to administer a dose of melatonin at least half an hour before anxiety-provoking events occur. Recently, a direct relationship between the relaxing properties of medicinal plants such as valerian roots and phytomelatonin content has been described [ 130 ].…”

Section: Melatoninmentioning

confidence: 99%

Essential Oils and Melatonin as Functional Ingredients in Dogs

Ruiz-Cano¹,

Sánchez-Carrasco²,

Mihyaoui

et al. 2022

Animals

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The use of nutraceuticals or functional ingredients is increasingly widespread in human food; their use is also widespread in animal feed. These natural compounds generally come from plant materials and comprise a wide range of substances of a very diverse chemical nature. In animals, these compounds, so-called phytogenics, are used to obtain improvements in feed production/stability and also as functional components with repercussions on animal health. Along with polyphenols, isoprenoid compounds represent a family of substances with wide applications in therapy and pet nutrition. Essential oils (EOs) are a group of complex substances with fat-soluble nature that are widely used. Melatonin is an indolic amine present in all living with amphiphilic nature. In this work, we present a review of the most relevant phytogenics (polyphenol, isoprenoid, and alkaloid compounds), their characteristics, and possible uses as nutraceuticals in dogs, with special emphasis on EOs and their regulatory aspects, applied in foods and topically. Additionally, a presentation of the importance of the use of melatonin in dogs is developed, giving physiological and practical aspects about its use in dog feeding and also in topical application, with examples and future projections. This review points to the combination of EOs and melatonin in food supplements and in the topical application as an innovative product and shows excellent perspectives aimed at addressing dysfunctions in pets, such as the treatment of stress and anxiety, sleep disorders, alopecia, and hair growth problems, among others.

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