Phytopathogenic Fungi and Toxicity

Salvatore, Maria Michela; Andolfi, Anna

doi:10.3390/toxins13100689

Cited by 21 publications

(13 citation statements)

References 15 publications

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“…Secondary metabolites are often used by microbes to enable unique trophic lifestyles, overcome competition with other microbes, or cope with environmental biotic and abiotic stress [ 28 , 29 , 30 , 31 ]. Hence, in this study, the production of secondary metabolites from a strain of D. corticola was examined with reference to its possible ecological role.…”

Section: Discussionmentioning

confidence: 99%

Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A

et al. 2022

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An undescribed 5,6-dihydropyran-2-one, namely diplopyrone C, was isolated and characterized from the cultures of an isolate of the fungus Diplodia corticola recovered from Quercus suber in Algeria. The structure and relative stereostructure of (5S,6S,7Z,9S,10S)-5-hydroxy-6-(2-(3-methyloxiran-2-yl)vinyl)-5,6-dihydro-2H-pyran-2-one were assigned essentially based on NMR and MS data. Furthermore, ten known compounds were isolated and identified in the same cultures. The most abundant product, the tetracyclic pimarane diterpene sphaeropsidin A, was tested for insecticidal effects against the model sucking aphid, Acyrthosiphon pisum. Results showed a toxic dose-dependent oral activity of sphaeropsidin A, with an LC50 of 9.64 mM.

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Section: Discussionmentioning

confidence: 99%

Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A

et al. 2022

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“…Furthermore, diverse SMs were identified from the Neofusicoccum species N. botryoisocoumarin A, and N. botryosphaerones that cause fruit ripe rot harvest disease. Of these, the SM isosclerone, is likely related to both fungal pathogenicity and virulence (Salvatore and Andolfi, 2021). In addition, some SM gene clusters are expressed in the host plant, and others are not.…”

Section: Antifungal Metabolites From Plantsmentioning

confidence: 99%

The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

et al. 2022

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The global environment is dominated by various small exotic substances, known as secondary metabolites, produced by plants and microorganisms. Plants and fungi are particularly plentiful sources of these molecules, whose physiological functions, in many cases, remain a mystery. Fungal secondary metabolites (SM) are a diverse group of substances that exhibit a wide range of chemical properties and generally fall into one of four main family groups: Terpenoids, polyketides, non-ribosomal peptides, or a combination of the latter two. They are incredibly varied in their functions and are often related to the increased fitness of the respective fungus in its environment, often competing with other microbes or interacting with plant species. Several of these metabolites have essential roles in the biological control of plant diseases by various beneficial microorganisms used for crop protection and biofertilization worldwide. Besides direct toxic effects against phytopathogens, natural metabolites can promote root and shoot development and/or disease resistance by activating host systemic defenses. The ability of these microorganisms to synthesize and store biologically active metabolites that are a potent source of novel natural compounds beneficial for agriculture is becoming a top priority for SM fungi research. In this review, we will discuss fungal-plant secondary metabolites with antifungal properties and the role of signaling molecules in induced and acquired systemic resistance activities. Additionally, fungal secondary metabolites mimic plant promotion molecules such as auxins, gibberellins, and abscisic acid, which modulate plant growth under biotic stress. Moreover, we will present a new trend regarding phytoremediation applications using fungal secondary metabolites to achieve sustainable food production and microbial diversity in an eco-friendly environment.

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“…(MIC 150–170 ppm), Rhizoctonia solani (EC 50 3906 ppm), Sclerotium rolfsii (EC 50 59.3 ppm) and Macrophomina phaseolina (EC 50 147.4 ppm) [ 40 , 64 ] ( Figure 2 ). These plant-pathogenic fungi harm plants by secreting virulence factors such as effector proteins, degrading enzymes, toxins and growth regulators that severely affect crop yield and quality, and consequently have a negative impact on agriculture [ 116 , 117 ]. Amongst them, the essential oil of Z. zerumbet , rich in zerumbone (51.3%), has been especially effective against Aspergillus spp.…”

Section: Further Uses Of Zerumbonementioning

confidence: 99%

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

Ibáñez

Sánchez-Ballester

Blázquez

2022

Plants

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Zerumbone is a multifunctional compound with antimicrobial, antitumor, hyperalgesic, antioxidant and anti-inflammatory applications, and constitutes a point molecule for the future synthesis of derivatives with improved efficiency. This monocyclic sesquiterpenoid is found in high content in wild ginger (Zingiber zerumbet Smith), a perennial herb with economic importance as an ornamental as well as a medicinal plant. The presence of zerumbone is a distinctive feature that allows identification and differentiation from other species, not only in Zingiber, but also in Curcuma, Alpinia, Boesenbergia, Ethlingera and Ammomum spp., as well as related families (Costaceaee). To successfully use zerumbone in areas such as medicine, food and agriculture, further research on improving its low solubility and bioavailability, as well as its preservation, is a major current priority. In addition, despite its promising pharmacological activities, preclinical and clinical studies are required to demonstrate and evaluate the in vivo efficacy of zerumbone.

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Phytopathogenic Fungi and Toxicity

Abstract: Phytopathogen fungi are responsible for serious plant diseases which might negatively affect crop productivity [...]

Cited by 21 publications

References 15 publications

Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A

Secondary Metabolites, including a New 5,6-Dihydropyran-2-One, Produced by the Fungus Diplodia corticola. Aphicidal Activity of the Main Metabolite, Sphaeropsidin A

The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

Healthy Zerumbone: From Natural Sources to Strategies to Improve Its Bioavailability and Oral Administration

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