Phytopharmacopoeial specifications of Garcinia indica fruit rinds

Kadam, Prasad V.; Yadav, Kavita; Patel, Ankita; Navsare, Vidya S.; Bhilwade, Sumeet K.; Patil, M. J.

doi:10.5530/pj.2012.31.5

Cited by 16 publications

(19 citation statements)

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“…Interestingly, a link between those pathophysiological mechanisms and nutrition has been established (Nomikos, Fragopoulou, & Antonopoulou, 2007;Xanthopoulou et al, 2010). Many plants, their extracts and isolated compounds have demonstrated a spectrum of biological activities and have been used as food supplements for various disorders (Kadam et al, 2012). One such plant, pumpkin is one of the vegetables that meet the requirements of healthy nutrition; it is a gourd-like squash of the genus Cucurbita and the family Cucurbitaceae.…”

Section: Introductionmentioning

confidence: 99%

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Sakka

Karantonis

2015

IJFS

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Pumpkin seeds are commonly consumed in Greece. Although Cucurbita moschata is locally grown in Lemnos and is traditionally used in pumpkin pies, the seeds are currently discarded after consumption of the fruit flesh. The aim of the present study was to investigate the nutritional functionality of pumpkin seeds from Cucurbita moschata grown in Lemnos. Cucurbita moschatas' seeds, raw or roasted, were appropriately extracted and the results are presented for raw versus (vs) roasted seed extracts. The phenolic content was expressed as µg gallic acid/g of seeds according to Folin-Ciocalteau assay (370.3 ± 19.1 vs 551.0 ± 22.0). Antioxidant capacity was expressed as equivalent amount for 50% scavenging in mg of seeds for DPPH (50.03 ± 5.91 vs 25.82 ± 6.77) and ABTS (17.85 ± 0.77 vs 12.77 ± 0.76) assays, and as µmol of trolox/g of seeds for FRAP (1.19 ± 0.05 vs 2.50 ± 0.23) and CUPRAC (2.13 ±0.11 vs 3.25 ± 0.06) assays. Anti-inflammatory/antithrombotic and anti-diabetic activities were expressed as mg of seeds for 50% inhibition of platelet activating factor (0.62 vs 0.15) and as µg of seeds for 25% inhibition of alpha-glycosidase (40.0 vs 61.0) activities respectively. Moreover, anti-atherogenic activity was expressed as the % increase in lag time of human plasma oxidation (62.7 versus 163.2) Raw and roasted pumpkin seed extracts exert anti-oxidant, anti-thrombotic/anti-inflammatory, antiatherogenic and antidiabetic activities. Cucurbita moschata seeds may represent a novel opportunity for development of functional foods, with a local interest in Lemnos that would contribute also to the regional public health improvement.

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Section: Introductionmentioning

confidence: 99%

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Sakka

Karantonis

2015

IJFS

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“…The microscopical images were made by using Motic Image Plus microscopic unit. (MOTIC-B1) 8,13 Micro chemical Testing The transverse section of fruit and powder were treated with specific staining reagent and observed under digital microscope (MOTIC-B1). The cell wall composition, cell contents and tissue detection was reported separately.…”

Section: -12mentioning

confidence: 99%

“…15 The limited moisture content signifies that the drug was properly dried and the rate of drying was good enough. The ash value represents inorganic salts, naturally occurring crude drug of the adulterant present 8,13 . The percent of extractive in different solvents shows the nature and quantity of the constituents in the drug.…”

Section: Physicochemical Evaluationmentioning

confidence: 99%

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Pharmacognostical Evaluation of Fruits of Mallotus Philippenensis (Lam). Muell- Arg (Euphorbiaceae)

Kadam¹,

Bhingare²,

Soni³

et al. 2013

J Pharm Sci Innov

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ABSTRACT:Correct identification of starting material is necessary to ensure the quality of herbal medicines. Pharmacognostic evaluation is first step towards establishing identity and purity of crude drug. With this aim the present paper deals with study of pharmacognostic and physicochemical characteristics of fruits of Mallotus philippinensis (lam) Muell. Arg. (Euphorbiaceae). The powder of Mallotus philippinensis was used for detection of various chemical constituents. The transverse section and the powder of fruit were studied for macroscopy, microscopy and physicochemical parameters. Fruit is globose, 3-lobed capsule with abundant orange or reddish glandular granules. The Microscopy showed the presence of epicarp, mesocarp endocarp. The cells also showed the presence of starch. From the pharmacognostical evaluation it was found that the fruit contains alkaloids, saponins, flavanoids etc. Physicochemical parameters were also within the limit. It can be concluded that Pharmacognostic evaluation can serve as tool for developing standards for identification, quality and purity of M. philippinensis.

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“…The parts of the plant such as roots, leaves, fruit rind have been traditionally used in several herbal preparations. 11 Several phytoconstituents like xanthones, biflavonoids, benzophenones, hydroxycitric acid, fatty acids, glycerides, anthocyanins, garcinol, camboginol, etc which exhibit significant hypolipidemic and hypoglycemic activity have been isolated from several parts of the tree. 12 However through this study we have evaluated the hypoglycemic effects of methanolic extract of seeds of Garcinia indica on blood glucose levels in Streptozotocin induced diabetic albino rats.…”

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Evaluation of the oral hypoglycemic activity of methanolic extract of Garcinia indica seeds in streptozotocin induced diabetic Albino rats

Shetty

Pushpa

2018

Int J Basic Clin Pharmacol

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Background: Diabetes mellitus is a multifactorial metabolic disorder with several microvascular and macrovascular complications. Several plants have been used as dietary adjuvants to conventional drug therapy. Garcinia indica exhibits significant hypolipidemic and hypoglycemic activity. This study was conducted to evaluate the hypoglycemic effects of methanolic extract of seeds of Garcinia indica on blood glucose levels in Streptozotocin induced diabetic albino rats.Methods: Five groups of wistar albino rats (n=6) weighing 150-200g of either sex aged 3-4 months were obtained for the study. After overnight fasting, streptozotocin (50mg/kg) was administered intraperitoneally to induce diabetes. Five groups are: Group-1: Non diabetic control group, Group-2: diabetic control, Group-3: diabetic standard, Group-4: test group, Group-5: half of test + half of standard. Fasting blood sugar was estimated on 1, 3, 7, 14 and 28th day by capillary blood glucose method. The data obtained were subjected to statistical analysis.Results: In this study, following Streptozotocin administration the blood glucose levels increased in all groups on day 0. In group 2, blood glucose level gradually increased to 445.6±1.75mg/dl over a period of 4 weeks. Following glibenclamide administration in Group 3 - there was a gradual reduction in blood glucose levels: 269.8mg/dl - day 7 to 101.8mg/dl - week 4. Group 4 - persistent and significant (p<0.05) fall in blood glucose levels reaching upto 107mg/dl at the end of 4 weeks. Group 5 - 330mg/dl on day 1 which significantly (p<0.05) reduced to 101mg/dl on day 28. There was improvement in weight in group 4 and group 5 diabetic rats.Conclusions: The extract alone and in combination with glibenclamide showed significant hypoglycemic activity in comparison to diabetic control group.

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Phytopharmacopoeial specifications of Garcinia indica fruit rinds

Cited by 16 publications

References 1 publication

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

In vitro health beneficial activities of Pumpkin seeds from Cucurbita moschata cultivated in Lemnos

Pharmacognostical Evaluation of Fruits of Mallotus Philippenensis (Lam). Muell- Arg (Euphorbiaceae)

Evaluation of the oral hypoglycemic activity of methanolic extract of Garcinia indica seeds in streptozotocin induced diabetic Albino rats

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