Phytopharmacy

Edwards, Sarah E.; Rocha, Inês da Costa; Williamson, E. M.; Heinrich, Michael

doi:10.1002/9781118543436

Cited by 61 publications

(49 citation statements)

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“…At the 100 mg/Kg dose, Vo.Cr showed maximum anxiolytic effect, but at next highest tested dose (300 mg/Kg), its effect was reduced, because of decreased exploratory activities, possibly be due to co-existent sedative component of the plant. Verbena officinalis has been reported for presence of flavonoids (apigenin, luteolin, quercetion, kaempferol) and tannins (Mengiste et al, 2014; Edwards et al, 2015), which are well-known for their anxiolytic and central nervous system depressant (sedative) activities (Adeyemi et al, 2006; Coleta et al, 2008; Aguirre-Hernandez et al, 2010). Several flavonoids bind to the benzodiazepine site on GABA A -receptors to provoke anti-seizure, anti-anxiety and sedative effects (Jager and Saaby, 2011), evidencing that observed actions of Verbena officinalis mediated possibly through activation of GABA A -receptors pathway.…”

Section: Discussionmentioning

confidence: 99%

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

Khan

Ahmed

2016

Front. Pharmacol.

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We describe different neuropharmacological effects of Verbena officinalis crude extract (Vo.Cr). Pentylenetetrazole (PTZ)-induced seizures, elevated plus maze, light–dark box (LDB), open field and thiopental-induced sleeping test models were employed to evaluate Vo.Cr actions in mice. Vo.Cr dose-dependently (100–500 mg/Kg) delayed onset time of myoclonic jerks and tonic-clonic seizures, while decreased duration of tonic-clonic seizures (P < 0.05, P < 0.001 vs. saline group). Vo.Cr at 100 and 300–500 mg/Kg doses reduced animals’ mortality in PTZ-induced seizures test to 75 and 0%, respectively. Vo.Cr (50–300 mg/Kg) significantly increased time spent and number of entries into open arms, while decreased time spent and number of entries into closed arms (P < 0.05, P < 0.01, P < 0.001 vs. saline group), measured in elevated plus maze. Vo.Cr (50–300 mg/Kg) increased time spent in light compartment, while decreased time spent in dark compartment (P < 0.01, P < 0.001 vs. saline group) in LDB, like caused by diazepam. In open field test, Vo.Cr decreased number of ambulations and rearings frequencies, while increased the number of central squares crossings. In thiopental-induced sleeping test, Vo.Cr (50–300 mg/Kg) decreased onset time of sleep, while increased the duration of sleep (P < 0.05, P < 0.01, P < 0.001 vs. saline group). These results indicate that Verbena officinalis possess anticonvulsant, anxiolytic and sedative activities, which provides scientific background for its medicinal application in various neurological ailments, such as epilepsy, anxiety, and insomnia.

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Section: Discussionmentioning

confidence: 99%

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

Khan

Ahmed

2016

Front. Pharmacol.

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“…Based on the existing scientific evidence and stringent quality regulations, registered/licensed herbal medicinal products (HMPs) are not part of Complementary and Alternative Medicine (CAM). They are pharmacologically active medicines and need to be treated similarly to conventional medicines, requiring a paradigm shift by health professionals .…”

Section: The Importance Of Herbal Medicines and Potential Risks Of Thmentioning

confidence: 99%

Quality and safety of herbal medical products: regulation and the need for quality assurance along the value chains

Heinrich

2015

Brit J Clinical Pharma

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Herbal medicines and products derived from them are a diverse group of products for which different (and often limited) levels of evidence are available. As importantly, such products generally vary in their composition and are at the end of an often poorly understood value chain, which often links producers in biodiversity rich countries with the large markets in the North. This paper discusses the current regulatory framework of such herbal medical products (with a focus on the UK) and using examples from our own metabolomic research on Curcumal longa L. (turmeric, Zingiberaceae) how value chains impact on the composition and quality (and thus the safety) of such products. Overall, our recent research demonstrates the need for studying the links between producers and consumers of commodities produced in provider countries and that plant metabolomics offer a novel way of assessing the chemical variability along a value chain.

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“…It is a tree indigenous to the Amazonian rainforest and other regions of South America and Latin America. Pau d'arco has been used in traditional medicine for many centuries due to its different physiological effects such as fungicide, antibacterial, antiviral, anti-inflammation, and anticancer [ 43 ]. Above all, special attention has been given to the antitumour activity of β -lapachone (i.e., a constituent of lapacho) against many in vitro cancer cell lines, including breast cancer [ 44 , 45 ] due to its action on reinforcing the immune system.…”

Section: Phytotherapymentioning

confidence: 99%

Phytotherapy and Nutritional Supplements on Breast Cancer

Lopes

Dourado²,

Oliveira

2017

BioMed Research International

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Breast cancer is the most frequent type of nonskin malignancy among women worldwide. In general, conventional cancer treatment options (i.e., surgery, radiotherapy, chemotherapy, biological therapy, and hormone therapy) are not completely effective. Recurrence and other pathologic situations are still an issue in breast cancer patients due to side effects, toxicity of drugs in normal cells, and aggressive behaviour of the tumours. From this point of view, breast cancer therapy and adjuvant methods represent a promising and challenging field for researchers. In the last few years, the use of some types of complementary medicines by women with a history of breast cancer has significantly increased such as phytotherapeutic products and nutritional supplements. Despite this, the use of such approaches in oncologic processes may be problematic and patient's health risks can arise such as interference with the efficacy of standard cancer treatment. The present review gives an overview of the most usual phytotherapeutic products and nutritional supplements with application in breast cancer patients as adjuvant approach. Regardless of the contradictory results of scientific evidence, we demonstrated the need to perform additional investigation, mainly well-designed clinical trials in order to establish correlations and allow for further validated outcomes concerning the efficacy, safety, and clinical evidence-based recommendation of these products.

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Phytopharmacy

Cited by 61 publications

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Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

Anticonvulsant, Anxiolytic, and Sedative Activities of Verbena officinalis

Quality and safety of herbal medical products: regulation and the need for quality assurance along the value chains

Phytotherapy and Nutritional Supplements on Breast Cancer

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