Phytosomes: The New Technology for Enhancement of Bioavailability of Botanicals and Nutraceuticals

Bhattacharya, Sanjib

doi:10.4314/ijhr.v2i3.47905

Cited by 85 publications

(51 citation statements)

References 12 publications

(15 reference statements)

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“…Thereby, nanonisation of plant extracts could be a valuable aid to increase the efficiency of plant extract and minimise their side effects. [17] Scanning electron images of surface morphology of prepared nanosuspension revealed their smooth texture. Their pictures showed that most of the particles were having spherical shape and smooth topology.…”

Section: Particle Size Analysis and Morphological Characterisationmentioning

confidence: 96%

Formulation and characterisation of nanosuspension of herbal extracts for enhanced antiradical potential

Jahan

Aslam

Rahman

et al. 2015

Journal of Experimental Nanoscience

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Nanotechnology is a promising technique to increase the bioavailability of herbal medicines. This paper presents the nanosuspension approach for increasing the aqueous solubility and thereby bioactivity of important herbal extracts. Nanosuspensions of the seeds of three plants extract (Silybum marianum, Elettaria cardamomum and Coriandrum sativum) were prepared by using polyvinyl alcohol (1.5% w/v) as a stabiliser. Prepared nanoparticles were characterised by scanning electron microscope. Activity of nanosuspension formulation was assessed by using four in vitro antioxidant assays. S. marianum, E. cardamomum and C. sativum particle size was observed to fall in range of 446.1 § 112.6, 456.63 § 339.2 and 432.1 § 172.8 nm, respectively, most of the particles were having spherical shape and smooth topology. These synthesised nanoparticles were found to be more effective against quenching free radical than their crude extracts and standards [butylated hydroxyl toluene and ascorbic acid]. C. sativum nanosuspension showed most free radical scavenging potential against 2,2-diphenyl-1-picrylhdrazyl (DPPH) and superoxide free radical scavenging assays (IC 50 0.59 § 0.01 and 0.81 § 0.11 mg/ml). S. marianum nanosuspension was found to be most effective against DPPH radicals scavenging (IC 50 0.34 § 0.02 mg/ml). It was concluded that nanosuspension of herbal medicines potentiates the antioxidant potential.

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Section: Particle Size Analysis and Morphological Characterisationmentioning

confidence: 96%

Formulation and characterisation of nanosuspension of herbal extracts for enhanced antiradical potential

Jahan

Aslam

Rahman

et al. 2015

Journal of Experimental Nanoscience

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“…Due to drugphospholipid complex formation the bioavailability of the active constituent is increased, along with prolonged duration of action. [17] …”

Section: Role Of Phosphatidylcholine In Phytosome Preparationmentioning

confidence: 99%

Untitled

Nanavati¹

2017

AJP

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Novel drug delivery systems have gained significant importance because of their enhanced bioavailability and overall therapeutics. Hydrophilic nature and unique chemical structure of most of the therapeutically useful phytoconstituents which result in poor bioavailability and less absorption. The water soluble phytoconstituents have excellent bioactivity in vitro, but less or no action in vivo. Phytosome technology can overcome this problem in which the phytoconstituent is allowed to react with phospholipid. The phytoconstituent with poor lipid solubility on complexation into phytosome, can exhibit better pharmacodynamics and pharmacokinetics profile as compared to conventional herbal extract. Phytoconstituent must have good hydrophilicity which helps in dissolution in gastrointestinal fluid and hydrophobicity which helps cross lipid-rich cell membrane. Phytosome technology results in an intermolecular bonding between phospholipid, phosphatidylcholine and a single molecule of phytoconstituent. Phosphatidylcholine used in phytosome technology has also proven its clinical efficacy by acting as a carrier for fat and water miscible nutrients and natural digestive aid. Phytosomes can be used to treat acute and chronic liver failure due to improved pharmacological and pharmacokinetic property. In market, many products based on phytosome technology are available which include herbal extracts and phytochemicals with great therapeutic potential such as curcumin, ginkgo biloba, grape seed, silymarin, and many more. The present review highlights the method of preparation, properties, advantages, characterization, and applications.

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“…They are cell membrane building blocks, making up the matrix into which fit a large variety of proteins that are enzymes, transport proteins, receptors, and other biological energy converters. In humans and other higher animals the phospholipids are also employed as natural digestive aids and as carriers for both fat-miscible and water miscible nutrients 4 .…”

Section: Disadvantages Of Herbal Medicinesmentioning

confidence: 99%

“…The leaves have also been shown to possess good anti-stress and analgesic activity. 4. Curcuma Longa (Turmeric) 50,51 : Turmeric commonly known as Haldi and has been used for thousands of years as a dye, a flavoring and a medicinal herb.…”

Section: Ginkgoselect Phytosome Vs Ginkgo Biloba Extractmentioning

confidence: 99%

Untitled

2013

IJPSR

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Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. Our country has a vast knowledge base of Ayurveda whose potential is only being realized in the recent years.The effectiveness of any herbal medication is dependent on the delivery of effective level of the therapeutically active compound. Severe limitation exists in their bioavailability when administered orally or topically. Phytosomes are recently introduced herbal formulations that are better absorbed and as a result produce better bioavailability and actions than the conventional phyto-molecules or botanical extracts. In the recent days, most of the prevailing diseases and nutritional disorders are treated with natural medicines. Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or both, resulting in poor absorption and bioavailability. So, much work has been directed towards the development of new concept in herbal delivery system i.e., "phytosomes" which are better absorbed, utilized and as a result produce better results than conventional herbal extracts owing to the presence of phosphatidylcholine which likely pushes the phytoconstituent through the intestinal epithelial cell outer membrane, subsequently accessing the bloodstream phytosomes have improved pharmacokinetic and pharmacological parameter which in result can advantageously be used in the treatment of the acute and chronic liver disease of toxic metabolic or infective origin or of degenerative nature.

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Phytosomes: The New Technology for Enhancement of Bioavailability of Botanicals and Nutraceuticals

Cited by 85 publications

References 12 publications

Formulation and characterisation of nanosuspension of herbal extracts for enhanced antiradical potential

Formulation and characterisation of nanosuspension of herbal extracts for enhanced antiradical potential

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