Phytosterols as precursors for the synthesis of aromatase inhibitors: Hemisynthesis of testololactone and testolactone

Synthesis of an unusual quinazoline alkaloid: theoretical and experimental investigations of its structural, electronic, molecular and biological properties

“…8,9 In general alkaloids possess a range of biological activities which include analgesic, antiviral, antimalarial, antineoplastic, antimicrobial, anti-inammatory, antioxidant antifungal, antibacterial, hemoglobinization agents of human leukemia cells, effects on the CNS, estrogenic effects etc. [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Based on these literature reports of alkaloids and our previous work on the isolation, and synthesis of bioactive compounds, [25][26][27][28][29][30][31][32][33][34][35][36][37] we carried out the synthesis of an unusual selfcondensation product of 2-aminobenzaldehyde by a method reported by Seidal and coworkers. 38 In order to get deeper insights in to the molecular, structural and biological properties of the synthesized compound, we resorted to spectral, X-ray and DFT analysis.…”

New Semi-Synthetic Rosmarinic Acid-Based Amide Derivatives as Effective Antioxidants

“…A rigorous literature precedent revealed that there are no such reports underscoring the structure activity relationship (SAR) linking the effect of aryl substituents tethered via amide linkage to the parent molecule on the antioxidant activity of the resulting synthetic analogs. Keeping these facts in mind as well as our previous work on natural product based synthesis, we directed this work towards the synthesis of a diverse series of novel amide derivatives of biological interest using RA as the key template. All its synthesized analogs were then subjected to DPPH, hydroxyl radical and reducing power assay to check their antioxidant potential.…”

Cycloartane and Stigmastane Type Triterpenoids from Pothos scandens Inhibit Estradiol (E2) Induced Proliferations in Breast Cancer Cells

“…However, a ferulate moiety was observed in 4, which was configured on the basis of an ABX-type aromatic protons signal [δ H 6.98 6) in literatures. [25][26][27] Compound 7 was obtained as a white amorphous powder and it showed similar NMR spectra appropriate for stigmastane type skeleton. The 1 H NMR spectrum showed an anomeric proton signal [δ 4.21 (1H, d. J = 7.5 Hz, Glc-1′), suggesting a glycosidic linkage at position C-3.…”