Phytotherapeutics: an evaluation of the potential of 1000 plants

Cravotto, Giancarlo; Boffa, Luisa; Genzini, L.; Garella, Davide

doi:10.1111/j.1365-2710.2009.01096.x

Cited by 138 publications

(80 citation statements)

References 94 publications

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“…The usual daily dietary intake of anthocyanins is of approximately 200 mg (Zafra-Stone et al, 2007). Bilberry has higher anthocyanin content compared to other types of berries, such as strawberry, cranberry, elderberry and raspberry (Kowalczyk et al, 2003;Bagchi et al, 2004;Yildirim, 2006;Cravotto et al, 2010;Cocetta, 2012). The total anthocyanin content of bilberry is generally in the range of 300-700 mg per 100 g fresh fruit, although this range varies with cultivar, growing conditions and degree of ripeness of the berry (Upton, 2001;Burdulis et al, 2009).…”

Section: Total Anthocyanin Contentmentioning

confidence: 99%

Physicochemical and Bioactive Characteristics of Wild Grown Bilberry (Vaccinium myrtillus L.) Genotypes from Northeastern Turkey

Çelik

Bozhuyuk

Erċışlı

et al. 2018

Not Bot Horti Agrobo

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In the present study, fruit weight, fruit firmness, external fruit color, soluble solid content, pH, titratable acidity, vitamin C, total phenolics, total anthocyanins and antioxidant capacity of eight wild bilberry grown in Coruh valley in northeastern Turkey were determined. The blueberry cv. 'Bluecrop' was also studied to make comparison with bilberry genotypes. Antioxidant activity of bilberry and blueberry fruits were comparatively assessed by FRAP (Ferric reducing antioxidant power) assay. Significantly higher contents of phenolics and anthocyanins were found in bilberry fruits comparted with blueberry fruits. However, blueberry cv. 'Bluecrop' exhibited higher fruit weight and vitamin C content than bilberry fruits. Total phenolic and total anthocyanin content was 327 mg gallic acid equivalent and 142 mg of cyanidin-3-glucoside equivalent in 100 g fresh fruit in cv. 'Bluecrop', while it was between 492-563 mg gallic acid equaivalent and 307-342 mg of cyanidin-3-glucoside equivalent in 100 g fresh fruits of bilberry accessions. Moreover, wild accessions had approximately 2-3 folds higher antioxidant capacity than cv. 'Bluecrop'. The obtained results suggest the possibility of improving the bioactive and antioxidant properties of bilberry cultivars by using wild ones in cross breedings. It was also concluded that genotypes significantly affect the bioactive content of fruits and consequently the possibility of using wild bilberry fruits as a potential source of natural antioxidants in food industry is worth to be considered.

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Section: Total Anthocyanin Contentmentioning

confidence: 99%

Physicochemical and Bioactive Characteristics of Wild Grown Bilberry (Vaccinium myrtillus L.) Genotypes from Northeastern Turkey

Çelik

Bozhuyuk

Erċışlı

et al. 2018

Not Bot Horti Agrobo

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“…Many classes of compounds of plant origin bear future therapeutic promise for the prevention and treatment of many human diseases as well as regulation of fertility (Cravotto et al 2010). Of particular interest in relation to human health are the class of plant-derived oestrogenlike compounds known as the phyto-oestrogens, which embody several groups of widely distributed nonsteroidal oestrogens including isoflavones and lignans (Cassidy 2003).…”

Section: Introductionmentioning

confidence: 99%

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Saha¹,

Saraswat²,

Chakraborty³

et al. 2012

Reproduction

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The tubers of Pueraria tuberosa have folkloric repute as emmenagogue. The n-BuOH fraction of the ethanolic extract of tubers exhibits significant antifertility activity in laboratory animals. The present investigation explored the active principle(s) of the tuber extract with reference to contragestive effects in rats and probed the possible mechanism of action. Bioactivity-guided fractionation identified puerarin as the major constituent that exerted pregnancy-terminating effects. Oral administration of puerarin at R300 mg/kg per day for days (D) 1-2 post-coitus resulted in complete implantation failure. Serum oestradiol levels during D2-D5 and progesterone (P 4 ) level on D5 remained unaffected, but the endometrial expression of oestrogen receptor a (ERa) and ERb was adversely modulated that disrupted the implantation-specific characteristic endometrial oestrogenic milieu. The eventual consequence was loss of endometrial receptivity characterised by down-regulation of the uterine expression of P 4 receptor (PR) and attenuation of endometrial expression of leukaemia inhibitory factor, vascular endothelial growth factor and cyclo-oxygenase-2, the three important signalling molecules involved in the process of implantation. Light microscopic examination of the embryos demonstrated no untoward effect of puerarin on the development of embryos until D4, but D5 blastocysts underwent gross morphological distortion. The findings taken together are interpreted to suggest that puerarin adversely impacts the uterine expression of ER and PR that disrupts the implantation-conducive uterine milieu and prevents implantation. In conclusion, puerarin may be envisaged as a prospective molecule that merits further exploration for the development of non-steroidal post-coital contraceptive for women.

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“…[3] Many herbs have shown positive results in-vitro, animal model or small-scale clinical test. [4] In this line seaweeds are large subset of a group known as algae.…”

Section: Introductionmentioning

confidence: 99%

Insilico Homology Modeling Ofribulose-1,5-Bisphosphate Carboxylase Protein in Gracilaria Edulis

Elsie¹

2017

WJPPS

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Seaweeds are the subset of a larger group known as the algae. It has been widely used in many countries as a source of food and additionally has biomedical and industrial applications such as cosmetic, paint, crop, textile, paper, rubber, and building industries.The marine algae are essential to nature and directly valuable to humans since they have antioxidant, antimicrobial, antiviral, anticancer, anticoagulant and heme agglutinating properties. Moreover, nitrogen containing seaweeds are generally useful as good nutritive source for plants used as fertilizers. Further their applications extend in industrial level as weight reducer, raw materials for fuel production and useful adsorbent for waste water treatment. Moreover, these seaweeds have many beneficial effects and hence could be developed into potential products for biomedical and industrial applications. In this research study we found out the potential mutation gene and to perform protein sequence analysis, protein modeling using Bioinformatics tools. There are three steps involved in our present research investigation. The protein primary structure analysis, Secondary structure analysis and protein three dimensional structure prediction.

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Phytotherapeutics: an evaluation of the potential of 1000 plants

Cited by 138 publications

References 94 publications

Physicochemical and Bioactive Characteristics of Wild Grown Bilberry (Vaccinium myrtillus L.) Genotypes from Northeastern Turkey

Physicochemical and Bioactive Characteristics of Wild Grown Bilberry (Vaccinium myrtillus L.) Genotypes from Northeastern Turkey

Puerarin, a selective oestrogen receptor modulator, disrupts pregnancy in rats at pre-implantation stage

Insilico Homology Modeling Ofribulose-1,5-Bisphosphate Carboxylase Protein in Gracilaria Edulis

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