Phytotherapie bei benignem Prostatasyndrom und Prostatakarzinom

Abstract

In some countries plant extracts have belonged to the most popular drugs for the treatment of the benign prostatic syndrome (BPS) for decades; however, only few of the large number of published studies meet the criteria of the WHO benign prostatic hyperplasia (BPH) consensus conference. The few placebo-controlled long-term (study period >6 months) studies suggest a positive effect of some extracts (saw palmetto fruit, β-sitosterol, urtica, rye grass and a saw palmetto/urtica combination) on lower urinary tract symptoms (LUTS), urinary flow rate, post-void residual volume but effects on prostate volume or prostate-specific antigen (PSA) were only inconsistently demonstrable. To date no study has proven an effect on disease progression, such as acute urinary retention or need for surgical interventions. Due to the controversial data various extraction techniques and compositions of various products, neither American, European, British nor German BPH guidelines recommend plant extracts for the indication BPS although some placebo-controlled trials provided encouraging data. Further prospective studies according to WHO standards are required to determine the role of plant extracts for the management of BPS. For the indication of prostate cancer (PCa) plant extracts have been evaluated for disease prevention and management of several tumor stages but none of these studies have provided convincing evidence that plant extracts are superior to placebo and none of the Pica guidelines have recommended their use.Based on current knowledge plant extracts can never supplement evidence-based PCa management and should be used only in addition to the standard treatment. There is no scientific evidence for the use of dietary supplementation with high doses of vitamins or selenium-containing products.

Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases

“…The results showed that β-sitosterol inhibits 5α-R2 at a very high concentration (2.7 mM), but decreases the weight of the prostate in gonadectomized hamsters treated with T. Thus, the pharmacological effect produced by β-sitosterol is a consequence of its binding to the AR [82]. …”

Phytotherapie bei Erkrankungen der Prostata

“…Als häufigste Gründe für die Behandlung mit pflanzlichen Arzneimitteln werden eine gute Verträglichkeit und eine daraus resultierende gute Compliance der Patienten beschrieben. Daher erfolgt häufig die Erstbehandlung mit Phytopharmaka [3].…”