Phytotherapy for diabetic dyslipidemia: evidence from clinical trials

Ghorbani, Ahmad

doi:10.2217/clp.13.26

Cited by 40 publications

(23 citation statements)

References 66 publications

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“…It has passed several animal and clinical studies and its beneficial effects on blood glucose and lipids have been shown in diabetic patients since 36 years ago (Ghorbani, 2013b). Effect of M. charantia fruit on pancreatic histopathological changes has been determined by at least five experimental studies.…”

Section: Momordica Charantiamentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

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Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/ regenerative effects of such phytochemicals and their potential side effects were discussed. Embora medicamentos disponíveis atualmente sejam úteis no controle de complicações da Diabetes, complicações aparecem em grande número de pacientes. Considerando-se a fisiopatologia do Diabetes, a prevenção da degeneração de células beta e o estímulo da regeneração endógena de ilhotas será abordagem essencial para o tratamento de diabetes mellitus insulino-dependente. A presente revisão aborda compostos fitoquímicos, cujo efeito é provado na proteção/regeneração de células beta de pâncreas. Entre centenas de plantas que têm sido investigadas para o diabetes, pequena fração tem mostrado propriedade regenerativa, que será descrita neste trabalho. Os processos de degeneração e de regeneração das células beta do pâncrease são descritos. Além disso, mecanismos propostos para efeitos de proteção e regeneração desses compostos fitoquímicos e seus possíveis efeitos colaterais também serão discutidos neste trabalho.Unitermos: Diabetes mellitus/tratamento. Diabetes mellitus/fitoterapia. Fitoterapia/Diabetes mellitus. Ilhotas/regeneração endógena. Células beta/proteção. Células beta/regeneração. Pâncreas. Plantas medicinais/propriedades regenerativas.

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Section: Momordica Charantiamentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

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“…In addition, the antihyperlipidemic activity of many medicinal plants has been reported in experimental studies [4]. Therefore, the use of natural compounds derived from medicinal plants, having the double effect of improving both glycemic and lipidemic profiles, may improve the management of diabetes and reduce cardiovascular risk in diabetic patients [5].…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic Effect of Thymus Satureioides Aqueous Extract in Streptozotocin-Induced Diabetic Rats

Kabbaoui

Chda

Mejrhit

et al. 2016

Int J Pharm Pharm Sci

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Objective:The aerial parts of Thymus satureioides have been traditionally used to treat diabetes mellitus and its complications in Morocco. The aim of the present study was to investigate the antidiabetic and antihyperlipidemic effects of the aqueous extract of Thymus satureioides aerial parts in streptozotocin (STZ) induced diabetic rats. Methods:Experimental diabetes was induced in overnight fasted rats by intraperitoneal injection of streptozotocin (45 mg/kg). Diabetic rats were orally administered with aqueous extract of Thymus satureioides (500 mg/kg b.w.) for 28 d. Glibenclamide (2 mg/kg), a standard antidiabetic drug, was used as a positive control drug. Body weight and fasting blood glucose (FGB) were measured every week. Oral glucose tolerance, change in lipid parameters, urea, creatinine, aspartate aminotransferase (ASAT) and alanine aminotransferase (ALAT) levels of diabetic rats were evaluated at the end of the treatment.Results: Administration of Thymus satureioides aqueous extract to diabetic rats for 28 d reduced their fasting blood glucose levels significantly compared to the diabetic control rats. The extract improved body weight and glucose tolerance in diabetic rats. The antihyperlipidemic assessment of the extract revealed a decrease in plasma total cholesterol, triglycerides, LDL levels and an increase in HDL level in the plasma of treated diabetic rats. Furthermore, the biochemical liver and kidney functional tests have shown that serum biomarkers of liver and renal dysfunction were significantly reduced in treated diabetic rats. Conclusion:The present findings suggest that Thymus satureioides extract has both antidiabetic and antihyperlipidemic effects in experimental diabetic rats which can be beneficial in the management of diabetes and its complications.

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“…In addition to hyperglycemia, impaired metabolism of lipid (dyslipidaemia) is also a general characteristic of diabetes such as increased level of serum triglyceride (TG) and low-density lipoprotein (LDL) and decreased level of high-density lipoprotein (HDL) (Feingold et al, 1992;Ghorbani, 2013). It is indicated that the hyperglycemia or dyslipidaemia simply cause oxidative stress resulting in cellular damage of different organs such as liver, kidney and pancreas (Kroger et al, 2011;Poitout and Robertson, 2002;Robertson, 2004).…”

Section: Introductionmentioning

confidence: 99%

Lamium album or Urtica dioica? Which is more effective in decreasing serum glucose, lipid and hepatic enzymes in streptozotocin induced diabetic rats: A comparative study

Mehran¹,

Norasfard²,

Abedinzade³

et al. 2015

Afr. J. Trad. Compl. Alt. Med.

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Objectives: Diabetes mellitus, the most common endocrine disorder, is defined by hyperglycaemia. Urtica dioica or stinging nettle is known to have antidiabetic effects. Lamium album or non stinging nettle is shown to have some beneficial effects such as antioxidant, and cytoprotective properties. The purpose of this study was to compare the effects of hydroalchoholic extract of L. album and U. dioica on serum glucose, lipids and hepatic enzymes level in sterptozotocin induced diabetic rats. Methods: Thirty-two male Wistar rats were randomly assigned into four groups; normal control, diabetic control, diabetic treated with U. dioica (100 mg/kg/daily), diabetic treated with L. album (100 mg/kg/daily) for 28 days. Serum glucose, cholesterol, triglyceride (TG), alanin trasaminase (ALT), alkaline phosphatase (ALP) and aspartate transaminase (AST) were measured. Results: U. dioica and L. album extracts caused significant decrease (p<0.05) in serum glucose level in diabetic rats. Compared to diabetic control, both extracts significantly decreased serum cholesterol, ALT, AST and ALP (p<0.05). The level of serum TG in diabetic rats treated with U. dioica was significantly lower than that of animals treated with L. album (p<0.05). Conclusion: it seems that administration of U. dioica and L. album extracts in diabetic rats may have similar lowering effects on the level of serum glucose, cholesterol and hepatic enzymes, albeit U. dioica might be more effective in improving serum TG as compared with L. album.

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Phytotherapy for diabetic dyslipidemia: evidence from clinical trials

Cited by 40 publications

References 66 publications

Pancreatic beta cell protection/regeneration with phytotherapy

Pancreatic beta cell protection/regeneration with phytotherapy

Antidiabetic Effect of Thymus Satureioides Aqueous Extract in Streptozotocin-Induced Diabetic Rats

Lamium album or Urtica dioica? Which is more effective in decreasing serum glucose, lipid and hepatic enzymes in streptozotocin induced diabetic rats: A comparative study

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