Phytotherapy of hypertension and diabetes in oriental Morocco

Ziyyat, Abderrahim; Legssyer, Abdelkhaleq; Mekhfi, Hassane; Dassouli, A; Serhrouchni, Mohamed; Benjelloun, W

doi:10.1016/s0378-8741(97)00077-9

Cited by 481 publications

(346 citation statements)

References 13 publications

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“…Soleimani et al [66] established that the methanolic extract of Equisetum arvense have anti-diabetic potential. In Morocco, the anti-diabetic activity of M. communis had been well established by Ziyyata et al [67]. The leaves of J. adhatoda and O. corniculata in Nepal are used to treat rheumatic pain, dysentery, and stomach disorders [68].…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical Documentation of Traditional Knowledge about Medicinal Plants used by Indigenous People in Talash Valley of Dir Lower, Northern Pakistan

Khan¹,

Ahmad²,

Rashid³

2018

J Intercult Ethnopharmacol

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to obtain ethnobotanical data from the local herbalist and elder villagers. Quantitatively, the ethnobotanical data were analyzed by using indices, Use Value, Relative frequency of citation, and Informant Agreement Ratio. Results: The study identified a total of 50 medicinal plant species belonging to 33 botanical families and 46 genera in the 17 villages. Lamiaceae with 6 species is the dominant family, and herbs (68%) the main sources of herbal formulations. Leaves (41%) are the main parts for ethnomedicine, and 32% of drug orally administrated in the form of decoction. Conclusion:The Talash Valley is rich in its medicinal plant's flora and the associated traditional knowledge. Ethnomedicine plays an important role in the local healthcare system. The finding of new medicinal uses, recipes; vernacular plant names, using new morphological parts, and harvesting methods in the current study show the importance of the documentation of plant resources and ethnobotanical knowledge. We suggest and recommend that documented plants to be screened for further ethnopharmacological studies. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 99%

Ethnobotanical Documentation of Traditional Knowledge about Medicinal Plants used by Indigenous People in Talash Valley of Dir Lower, Northern Pakistan

Khan¹,

Ahmad²,

Rashid³

2018

J Intercult Ethnopharmacol

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“…The dried pulp of Citrullus Colocynthis has been used for constipation, edema, bacterial infections, cancer and diabetes [8][9][10][11] A. Recently, the antioxidant effects and the effect of the aqueous extract of the pulp on kidney and liver functions were reported [12] .…”

Section: Introductionmentioning

confidence: 99%

In vivo, Acute, Normo-hypoglycemic, Antihyperglycemic, Insulinotropic Actions of Orally Administered Ethanol Extract of Citrullus colocynthis (L.) Schrab Pulp

Dallak¹,

Alkhateeb²,

Abbas³

et al. 2009

American J. of Biochemistry and Biotechnology

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Problem statement: Citrullus Colocynthis (L.) Schrab (cucurbitaceae family) (Handal) is a fruit commonly known as bitter apple or bitter cucumber. Traditionally, Citrullus colocynthis has been used for the treatment of diabetes. In particular, the acute effect and rout of administration of ethanol extract of the seedless pulp in vivo remains untested. We investigated the effect of different routs of administration and their hypoglycemic and insulinotropic effects of ethanol/water (20/80 V/V) extract of the dried seedless pulp of Citrullus colocynthis (L.) Schrab on normal and alloxan-induced diabetic rats. Approach: Rats were divided into two groups, normal and diabetic rats. Non-diabetic rats were fasted for 18 h before the beginning of the experimental procedure. About 250 µL of normal saline (i.e., vehicle) was administered to control groups either i.p. (Group I) or orally (Group III) using modified feeding canula. As 250 µL pulp extract was administered i.p. (Group II) or orally (Group IV). Five min, after the administration of the extract or vehicle, an Intraperitoneal Glucose Tolerance Test (IPGTT) was conducted (1.5 g glucose/kg) on groups I, II, III and IV, but not Groups V or VI. Alloxan-induced diabetic rats were fasted for 6 h before the beginning of the experimental procedure. They were divided into control (Group V) and treated groups (Group VI), each of 6 rats. As 250 µL of the extract (equivalent to 300 mg kg −1 ) was administered orally to alloxan treated-group, while 250 µL of the vehicle was administrated orally to the animals of control group. Serum samples were collected at 0, 1, 2, 3, 4 and 6 h following the treatment and were used for glucose and insulin determination. Results: Oral, but not intraperitonial (i.p.) administration of ethanol extract (300 mg kg −1 ) resulted in acute, significant (p<0.05) and time-dependent changes in rat serum glucose and insulin levels in both normal and alloxan-induced diabetic rats. In extract-treated alloxan-free rats, a maximum of 32.9% reduction in serum glucose levels was observed following Intraperitonial Glucose Tolerance Test (IPGTT) using glucose-oxidase assay. A maximum reciprocal increase of 59.5% in serum insulin levels following IPGTT was determined by ELISA. Further, in alloxan/ethanol extract-treated group, a maximum of 31% reduction in serum glucose levels as well as 370.2% increase in serum insulin levels following IPGTT were observed. Conclusion: These results demonstrated that oral administration of the ethanol extract of the dried seedless pulp of Citrullus colocynthis had normo-hypoglycemic (i.e., in normal rats), antihyperglycemic as well as insulinotropic actions in alloxan-induced diabetic rats.

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“…For this reason, it has been undervalued by most communities [1]. Despite this limitation, the stinging nettle has been extensively used for medicinal purposes [2][3][4]. For instance, fresh juice from the plant has been reported to stimulate the digestive system and flow of milk in nursing mothers, provide temporary relief from pain as well as treating fever and diabetes [2,3].…”

Section: Introductionmentioning

confidence: 99%

Anti-pyretic, Anti-inflammatory and Analgesic Activities of Aqueous Leaf Extract of Urtica Dioica (L.) in Albino Mice

Safari¹,

Ngugi²,

Orinda³

et al. 2016

Med Aromat Plants

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Phytotherapy of hypertension and diabetes in oriental Morocco

Cited by 481 publications

References 13 publications

Ethnobotanical Documentation of Traditional Knowledge about Medicinal Plants used by Indigenous People in Talash Valley of Dir Lower, Northern Pakistan

Ethnobotanical Documentation of Traditional Knowledge about Medicinal Plants used by Indigenous People in Talash Valley of Dir Lower, Northern Pakistan

In vivo, Acute, Normo-hypoglycemic, Antihyperglycemic, Insulinotropic Actions of Orally Administered Ethanol Extract of Citrullus colocynthis (L.) Schrab Pulp

Anti-pyretic, Anti-inflammatory and Analgesic Activities of Aqueous Leaf Extract of Urtica Dioica (L.) in Albino Mice

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