Phytotoxic flavonoids from roots of Stellera chamaejasme L. (Thymelaeaceae)

Yan, Zhiqiang; Guo, Hongru; Yang, Jiayue; Liu, Quan; Jin, Hui; Xu, Rui; Cui, Haiyan; Qin, Bo

doi:10.1016/j.phytochem.2014.07.013

Cited by 51 publications

(39 citation statements)

References 42 publications

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“…Stellera chamaejasme L. (Thymelaeaceae), a perennial weed, is distributed widely across the grasslands of Russia, Mongolia and China (Shirai et al, ; Yan et al, ; Yan, Zeng, Jin, & Qin, ). Its roots are commonly known as ‘Ruixianglang du’ in Chinese, and have been used in China as a traditional Chinese medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis (Xu, Qin, Li, & Xu, ; Zhang et al, ; Pan et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Its roots are commonly known as ‘Ruixianglang du’ in Chinese, and have been used in China as a traditional Chinese medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis (Xu, Qin, Li, & Xu, ; Zhang et al, ; Pan et al, ). Previous phytochemical studies of S. chamaejasme L. have shown that it contains various kinds of chemical components, including diterpene, lignans, coumarins, phenylpropanoid, flavonoids and volatile oil (Li, Shen, Bao, Chen, & Li, ; Yan et al, ; Zhang et al, ). Modern studies have suggested that flavonoids from S. chamaejasme L. are the main components that mostly contribute to the pharmacological efficacy (Liu et al, ; Liu & Zhu, ; Liu, Han, et al, ; Liu, Yang, et al, ), such as anti‐cancer activity (Liu et al, ; Li, Zhang, Pang, ZhengChen, & Gan, ), anti‐fatty liver (Wang, Li, Han, Wang, & Li, ) and anti‐HIV (Asada et al, ).…”

Section: Introductionmentioning

confidence: 99%

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A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study

et al. 2018

Biomedical Chromatography

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Stellera chamaejasme L. has been used as a traditional Chinese medicine for the treatment of scabies, tinea, stubborn skin ulcers, chronic tracheitis, cancer and tuberculosis. A sensitive and selective ultra-high liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the simultaneous determination of five flavonoids (stelleranol, chamaechromone, neochamaejasmin A, chamaejasmine and isochamaejasmin) of S. chamaejasme L. in rat plasma. Chromatographic separation was accomplished on an Agilent Poroshell 120 EC-C column (2.1 × 100 mm, 2.7 μm) with gradient elution at a flow rate of 0.4 mL/min and the total analysis time was 7 min. The analytes were detected using multiple reaction monitoring in positive ionization mode. The samples were prepared by liquid-liquid extraction with ethyl acetate. The UPLC-MS/MS method was validated for specificity, linearity, sensitivity, accuracy and precision, recovery, matrix effect and stability. The validated method exhibited good linearity (r ≥ 0.9956), and the lower limits of quantification ranged from 0.51 to 0.64 ng/mL for five flavonoids. The intra- and inter-day precision were both <10.2%, and the accuracy ranged from -11.79 to 9.21%. This method was successfully applied to a pharmacokinetic study of five flavonoids in rats after oral administration of ethyl acetate extract of S. chamaejasme L.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study

et al. 2018

Biomedical Chromatography

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“…The extracts of S. chamaejasme are beneficial medicine against cancer, hepatitis B virus, abdominal pains, sores and sciatica (Liu and Wang 2010;Yang and Chen 2008;Zhang et al 2013). (Ma et al 2009;Cui et al 2014;Yan et al 2014). (Ma et al 2009;Cui et al 2014;Yan et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Phylogenic diversity and tissue specificity of fungal endophytes associated with the pharmaceutical plant, Stellera chamaejasme L. revealed by a cultivation-independent approach

Jin

Yang

et al. 2015

Antonie van Leeuwenhoek

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The fungal endophytes associated with medicinal plants have been demonstrated as a reservoir with novel natural products useful in medicine and agriculture. It is desirable to explore the species composition, diversity and tissue specificity of endophytic fungi that inhabit in different tissues of medicinal plants. In this study, a culture-independent survey of fungal diversity in the rhizosphere, leaves, stems and roots of a toxic medicinal plant, Stellera chamaejasme L., was conducted by sequence analysis of clone libraries of the partial internal transcribed spacer region. Altogether, 145 fungal OTUs (operational taxonomic units), represented by 464 sequences, were found in four samples, of these 109 OTUs (75.2 %) belonging to Ascomycota, 20 (13.8 %) to Basidiomycota, 14 (9.7 %) to Zygomycota, 1 (0.7 %) to Chytridiomycota, and 1 (0.7 %) to Glomeromycota. The richness and diversity of fungal communities were strongly influenced by plant tissue environments, and the roots are associated with a surprisingly rich endophyte community. The endophyte assemblages associated with S. chamaejasme were strongly shaped by plant tissue environments, and exhibited a certain degree of tissue specificity. Our results suggested that a wide variety of fungal assemblages inhabit in S. chamaejasme, and plant tissue environments conspicuously influence endophyte community structure.

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“…Among the plant extracts tested, T. asiatica significantly increased the seed germination and seedling vigour by 1% and 5.6%, respectively when compared to hydroprimed control and it has also increased the fresh weight and dry weight of maize by 10% and 23%, respectively. Seed treatment with plant extract may positively or negatively affect seed quality variable which is mainly due to the presence of growth hormones, sterols, phytotoxicants, carbohydrates, minerals, betaines and trace elements like potassium, calcium and iron in extracts (Khan et al 2009;Yasmeen et al 2013;Yan et al 2014). Similar results have been obtained by various authors where seed treatment with extracts of Moringa not only reduced seedborne fungi but also increased seedling vigour in different crops (Stoll 1988;Nwangburuka et al 2012;Abdalla 2014).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of seed hydropriming with phytoextracts on plant growth promotion and antifungal activity in maize

Aiyaz

Divakara

Siddaiah

et al. 2015

International Journal of Pest Management

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Seed-borne fungi such as Fusarium verticillioides and Aspergillus flavus are capable of causing several diseases to maize (Zea mays L.) and produce mycotoxins, which can have adverse effects on animal health and productivity. In the present study, efficacy of 100 extracts of 20 different plant species were tested for their antimicrobial potential against toxigenic Fusarium verticillioides and Aspergillus flavus. Among these, extracts of Toddalia asiatica, Decalepis hamiltonii, Vitex negundo and Psoralea corylifolia reduced A. flavus and F. verticillioides incidence significantly. Hydropriming with T. asiatica plant extract increased seed germination and seedling vigour significantly; however, D. hamiltonii and V. negundo did not show any improvements in seed quality parameters tested. In turn, P. corylifolia treated seeds showed potent antimicrobial potential but reduced seed germination and seedling vigour. The present study revealed that hydropriming of maize seeds with some plant extracts can be a potent alternative strategy to control seed-borne toxigenic fungi and to increase the seed quality parameters in maize.

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Phytotoxic flavonoids from roots of Stellera chamaejasme L. (Thymelaeaceae)

Cited by 51 publications

References 42 publications

A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study

A UPLC‐MS/MS method for simultaneous determination of five flavonoids from Stellera chamaejasme L. in rat plasma and its application to a pharmacokinetic study

Phylogenic diversity and tissue specificity of fungal endophytes associated with the pharmaceutical plant, Stellera chamaejasme L. revealed by a cultivation-independent approach

Efficacy of seed hydropriming with phytoextracts on plant growth promotion and antifungal activity in maize

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