Phytotoxins from the Leaves of <i>Laggera decurrens</i>

Puyvelde, Lisanne Van; Bosselaers, Jan; Stevens, Christian V.; Kimpe, Norbert De; Gestel, J. Van; Damme, Patrick Van

doi:10.1021/jf980029a

Cited by 13 publications

(7 citation statements)

References 16 publications

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“…A previous study on the alcoholic extract of L . decurrens grown in Africa led to the isolation of two phytotoxic compounds, namely 3-hydroxythymoquinone and 5-acetoxy-2-hydroxythymol [ 8 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Antimicrobial and Free-Radical-Scavenging Activities of the Essential Oils from Euryops arabicus and Laggera decurrens

2011

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The essential oils of the aerial part of two Asteraceae species, namely Euryops arabicus Steud. and Laggera decurrens (Vahl.) Hepper and Wood, were studied by GC and GC/MS. In parallel the antimicrobial and antioxidant activities were evaluated. The investigation led to the identification of 48 and 44 compounds for both plants, respectively. The essential oil of E. arabicus was rich in oxygenated sesquiterpenes (39.9%). The oil also contained a high content of sesquiterpene hydrocarbons (24.1%). Compounds such as caryophyllene oxide (8.6%), T-cadinol (7.0%), spathulenol (5.2%), (E)-β-caryophyllene (6.0%) and 2-epi-(E)-β-caryophyllene (6.0%) were the main constituents of the oil. Oxygenated monoterpenes also predominated in L. decurrens (46.3%). The thymoquinone-derivative, 3-methoxy-2-methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione (28.1%), thymol (5.7%) and eudesma-11-en-4a-ol (7.0%) were the most abundant constituents. Both essential oils showed antimicrobial activity with MIC-values between 0.13–5.25 mg/mL. Furthermore, only the essential oil of L. decurrens exhibited a strong antioxidant activity (91%) at 500 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Antimicrobial and Free-Radical-Scavenging Activities of the Essential Oils from Euryops arabicus and Laggera decurrens

2011

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“…In Namibia, the extract of the plant roots or leaves is drunk to relieve stomach aches and to treat acne. [24,37] The plant is also employed as traditional herbal medicine to treat rheumatism and wounds. [38] L. mollis has several applications in traditional medicinal systems.…”

Section: Ethnobotanical Informationmentioning

confidence: 99%

The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review

Getahun

Sharma

Gupta

2019

Chemistry & Biodiversity

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Most species of the genus Laggera are often used in traditional and folk medicines for the treatment of jaundice, inflammation, leukemia, removing phlegm, bronchitis and bacterial diseases. The essential oils obtained from Laggera plants are rich sources of oxygenated monoterpenes and sesquiterpenes. Among oxygenated monoterpenes, aromatic ether 2,5‐dimethoxy‐p‐cymene is the most abundant and dominant compound of many essential oils of the Laggera species. Till today, to the best of our knowledge, chemical compounds of the essential oils and/or extracts of only eight Laggera species were reported from different countries. Thus, this review presents the chemical compositions and biological activities of the essential oils of these plants studied in thirteen countries. In addition, it discusses the reported ethnobotanical and ethnopharmacological information as well as biological activities of the extracts and some of the isolated compounds of Laggera plants species.

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“…The genus is rich in flavonoids, cyclitols, monoterpenes and sesquiterpenes (eremophilanes and eudesmanes). Flavones, fatty acids and their derivatives, sterols (stigmasterol and -sitosterol), phenolic acid like 2-hydroxybenzoic acid and phytotoxic thymol derivatives such as 3-hydroxythymoquinoneand 5-acetoxy-2-hydroxythymol were also reported from extracts of plants of the Laggera genus [1,2,6,7]. 2,5-Dimethoxy-p-cymene,humulene, -caryophyllene, -eudesmol, 10-epi--eudesmol and juniper camphor are the most frequent chemical compounds of EOs of these plants and the former (oxygenated monoterpene)…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, and antibacterial and antioxidant activities of essential oils from Laggeratomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae)

et al. 2020

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Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae), an endemic Ethiopian medicinal plant is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil (EO) of its leaves and inflorescence were documented. However, no data about chemical compositions of other parts EOs of the plant have been reported up to date. Moreover, there is no previous biological activity report on any parts EOs of this plant. Thus, in this study, the EOs were isolated from the stem barks and roots of this plant by hydrodistillation and analyzed using GC-MS to identify their components. In addition, antibacterial potentials of the oils were evaluated by disc diffusion and minimal inhibitory concentration methods. DPPH and H2O2 methods were also employed to assess their antioxidant properties. Oxygenated monoterpenes (71.82 and 77.51%), of which 2,5-dimethoxy-p-cymene (57.28 and 64.76%) and thymol methyl ether (9.51 and 8.93%) were identified as major components in EOs of stem barks and roots of L. tomentosa and the oils were the most potent in DPPH (IC50, 0.33 ± 1.10 and 0.39 3 ± 0.97 mg/mL) assay, respectively. Moreover, the EOs demonstrated appreciable activity towards the Gram positive (S. aureus and B. cereus) bacteria. Among these oils, the oil of the stem barks showed the greatest activity to the Gram positive (MIC = 0.625 mg/mL) bacteria. Therefore, the overall results suggest that EOs of L. tomentosa may have promising prospect for pharmaceutical, food and other industrial applications.

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Phytotoxins from the Leaves of Laggera decurrens

Cited by 13 publications

References 16 publications

Phytochemical Analysis and In Vitro Antimicrobial and Free-Radical-Scavenging Activities of the Essential Oils from Euryops arabicus and Laggera decurrens

Phytochemical Analysis and In Vitro Antimicrobial and Free-Radical-Scavenging Activities of the Essential Oils from Euryops arabicus and Laggera decurrens

The genus Laggera (Asteraceae) – Ethnobotanical and Ethnopharmacological Information, Chemical Composition as well as Biological Activities of Its Essential Oils and Extracts: A Review

Chemical composition, and antibacterial and antioxidant activities of essential oils from Laggeratomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae)

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