2024
DOI: 10.1101/2024.06.13.598808
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PI(3,5)P2asymmetry during mitosis is essential for asymmetric vacuolar inheritance

Mariam Huda,
Mukadder Koyuncu,
Cansu Dilege
et al.

Abstract: Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a low-abundance signaling lipid that plays crucial roles in various cellular processes, including endolysosomal system structure/function, stress response, and cell cycle regulation. PI(3,5)P2synthesis increases in response to environmental stimuli, yet how it changes in cycling cells under basal conditions remained elusive. Here, using in vivo biosensors and live cell imaging, we analyzed spatiotemporal changes in PI(3,5)P2levels during the cell cycle of th… Show more

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