2013
DOI: 10.1038/ncomms2489
|View full text |Cite
|
Sign up to set email alerts
|

PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma

Abstract: Inositol polyphosphate 5-phosphatases can terminate downstream signalling of phosphatidylinositol-3 kinase; however, their biological role in the pathogenesis of cancer is controversial. Here we report that the inositol polyphosphate 5-phosphatase, phosphatidylinositol 4,5-bisphosphate 5-phosphatase, has a tumour suppressive role in melanoma. Although it is commonly downregulated in melanoma, overexpression of phosphatidylinositol 4,5-bisphosphate 5-phosphatase blocks Akt activation, inhibits proliferation and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
112
1

Year Published

2014
2014
2024
2024

Publication Types

Select...
8
1

Relationship

2
7

Authors

Journals

citations
Cited by 71 publications
(113 citation statements)
references
References 57 publications
0
112
1
Order By: Relevance
“…85 Briefly, cells were seeded at 1,000 cells/well onto 6-well culture plates and allowed to grow for 24 h followed by the desired treatment. Cells were then allowed to grow for a further 12 d before fixation with methanol and staining with 0.5% crystal violet.…”
Section: Clonogenic Assaysmentioning
confidence: 99%
“…85 Briefly, cells were seeded at 1,000 cells/well onto 6-well culture plates and allowed to grow for 24 h followed by the desired treatment. Cells were then allowed to grow for a further 12 d before fixation with methanol and staining with 0.5% crystal violet.…”
Section: Clonogenic Assaysmentioning
confidence: 99%
“…Downregulation of PIB5PA, found in a proportion of melanomas, was due to histone hypoacetylation mediated by histone deacetylases through binding to the transcription factor Sp1 at the PIB5PA gene promoter. 42 HDAC inhibitors are being considered for the therapy of melanoma despite limited data available on posttranslational modifications of histones. 43 The histone methyltransferase SET Domain, Bifurcated 1 (SETDB1) is upregulated in melanoma and accelerates tumor development in zebrafish melanoma models harboring the BRAF V600E mutation.…”
Section: Histone Modificationmentioning
confidence: 99%
“…PTEN is found to be commonly mutated or lost in numerous types of human cancers 30,31 , and monoallelic loss of PTEN is functionally haploinsufficient to facilitate tumour growth in the context of other somatic mutations 32 . INPP5J, an inositol 5-phosphatase recently identified, suppresses PI3K/Akt signalling by reducing the phosphorylation level of p-Akt (Ser 473) and was recently found to be downregulated in human melanoma, leading to promotion of cell proliferation and tumorigenicity in vivo 12,33 . Knockout of INPP4A was shown to sustain Akt activation and thereby promote cell proliferation, survival and tumorigenesis of mouse embryonic fibroblasts 13,34 .…”
Section: Discussionmentioning
confidence: 99%