PI3K inhibition by BKM120 results in anti-proliferative effects on corticotroph tumor cells

Oliveira, Henrique Alves de; Bueno, Ana Carolina; Pugliesi, Renata; Júnior, R M P da Silva; Castro, Margaret de; Martins, Clarissa Silva

doi:10.1007/s40618-021-01735-w

Cited by 4 publications

(1 citation statement)

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“…However, a higher dosage of 4-AAQB reduced the protein expression of p53 and p21 [23]. CDK2 and CDK4 have been considered as the main regulators of G1 arrest [24,25], while p27 is an inhibitor of CDK2 and CDK4, and can lead to cell cycle arrest at the G1 phase [26][27][28]. Collectively, 4-AAQB inhibited the growth of HepG2 cells in vitro by inducing cell cycle arrest, mostly through p27-mediated decreases in CDK2 and CDK4.…”

Section: Introductionmentioning

confidence: 96%

The Protective Role of 4-Acetylarylquinolinol B in Different Pathological Processes

Zhao

Liu

Yang

et al. 2022

CIMB

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Antrodia cinnamomea is a traditional plant and a unique fungus native to Taiwan that has been reported to have many biological functions, including anti-inflammatory and anticancer activities. The compound 4-acetylarylquinolinol B (4-AAQB) is one of the main bioactive compounds in the stamens of Antrodia cinnamomea, and has many biological functions, such as anti-inflammatory, antiproliferative, blood sugar reduction, antimetastasis, and vascular tone relaxation. In recent years, the increasing evidences have shown that 4-AAQB is involved in many diseases; however, the relevant mechanisms have not been fully clarified. This review aimed to clarify the improvement by 4-AAQB in different pathological processes, as well as the compound’s molecular mechanisms, in order to provide a theoretical reference for future related research

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