We prove a Second Main Theorem type inequality for any log-smooth projective pair (X, D) such that X \ D supports a complex polarized variation of Hodge structures. This can be viewed as a Nevanlinna theoretic analogue of the Arakelov inequalities for variations of Hodge structures due to Deligne, Peters and Jost-Zuo. As an application, we obtain in this context a criterion of hyperbolicity that we use to derive a vast generalization of a well-known hyperbolicity result of Nadel.The first ingredient of our proof is a Second Main Theorem type inequality for any log-smooth projective pair (X, D) such that X \ D supports a metric whose holomorphic sectional curvature is bounded from above by a negative constant. The second ingredient of our proof is an explicit bound on the holomorphic sectional curvature of the Griffiths-Schmid metric constructed from a variation of Hodge structures.As a byproduct of our approach, we also establish a Second Main Theorem type inequality for pairs (X, D) such that X \ D is hyperbolically embedded in X.