Piceatannol: A Potential Futuristic Natural Stilbene as Fetal Haemoglobin Inducer

Kukreja, Aayush; Tandon, Samarth; Mishra, Amit Kumar; Tiwari, Archana

doi:10.7860/jcdr/2013/6239.3839

Cited by 6 publications

(5 citation statements)

References 29 publications

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“…Piceatannol possesses many biological roles and various mechanisms of action similar to those of resveratrol . It serves as an antioxidant, antileukemic, anti-inflammatory, and anti-Epstein–Barr virus compound and is also used in the treatment of cardiovascular diseases, , atherosclerosis, and inflammatory bowel diseases and provides protection against β-amyloid-induced oxidative stress and cell death. , In addition, piceatannol has a significant inhibitory effect on insulin receptor activation by modulating the phosphorylation ability of the receptor, required for downstream signaling; it appears to inhibit adipogenesis, the process by which preadipocytes develop into adipocytes, through the inhibition of insulin receptor activity in preadipocytes, and prevents type 2 diabetes . Moreover, it may be useful in stimulating osteoblastic activity, leading to the formation of bone, and it is also known to possess antimelanogenic activity …”

Section: Mechanism Of Actionmentioning

confidence: 99%

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

Ali-Seyed

Jantan

Bukhari

et al. 2016

J. Agric. Food Chem.

154

102

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Cancer is a diverse class of diseases characterized by uncontrolled cell growth that constitutes the greatest cause of mortality and morbidity worldwide. Despite steady progress, the treatment modalities of cancer are still insufficient. Several new concepts have emerged for therapeutic intervention in malignant diseases with the goal of identifying specific targets and overcoming resistance against current cytotoxic therapies. Many studies have reported the remarkable and significant properties of dietary plant polyphenols such as curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, epigallocatechin gallate, and cucurbitacin as anticancer agents known for their pleiotropic effects on cancer, immune cells, and inflammation. Piceatannol, an analogue and metabolite of resveratrol, is a natural stilbene commonly found in grape skins and wine. Compared to resveratrol, this molecule exhibits superior bioactivities as an inhibitor of COX-1/2 and the CSN-associated kinase. Piceatannol is thought to be a potent natural compound with many therapeutic effects, such as the prevention of hypercholesterolemia, arrhythmia, atherosclerosis, angiogenesis, and cardiovascular diseases. It also demonstrates vasorelaxation, antioxidant, and anticancer activities. This comprehensive review summarizes the current data regarding the mechanisms of action of piceatannol, its chemopreventive properties, and its possible therapeutic potential against various types of human cancer.

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Section: Mechanism Of Actionmentioning

confidence: 99%

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

Ali-Seyed

Jantan

Bukhari

et al. 2016

J. Agric. Food Chem.

154

102

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“…Introduction of novel hemoglobin F inducers like simvastatin and some herbal products such as Wheatgrass, Piceatannol, and Resveratrol has brought some hope to patients to get rid of transfusion with the aid of natural products. 14 , 15 , 16 , 17 , 18 , 19 Furthermore, there are promising results that some botanical products as well as CAM practices such as cupping therapy ( Hijamat ) may help to decrease serum ferritin and reduce iron burden in thalassemia patients. 19 , 20 , 21 , 22…”

Section: Introductionmentioning

confidence: 99%

Complementary and alternative medicine use in thalassemia patients in Shiraz, southern Iran: A cross-sectional study

Bordbar

Pasalar

Safaei

et al. 2018

Journal of Traditional and Complementary Medicine

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This study aimed to determine the frequency and pattern of complementary and alternative medicine (CAM) use in thalassemia patients in south of Iran. The survey was done using a validated questionnaire which was distributed among 122 thalassemia patients. Only 108 questionnaires were completed and turned back (response rate 88.5%). Patients referred to an outpatient thalassemia clinic in Shiraz, southern Iran for blood transfusion. The mean age of the patients was 22.9 ± 7.9 years (range 4–45 years) with female/male ratio 1.84. Seventy four (68.5%) of the responders used CAM at least once during their life, and about half of them used it concurrently with their conventional treatments. The most reported CAM product was mint juice (50%). The most common reason of CAM use was increased general health. The most common information source about CAM was physicians who were the most trusted source as well. CAM is frequently being used in thalassemia patients to ensure their sense of well-being and help them overcome the complications of their illnesses.

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“…As it has been commented on above. various positive effects on the human health have been recognized in this class of phenolic compounds, additionally they seem to be an excellent antioxidant, stronger even than resveratrol [10]. …”

Section: Introductionmentioning

confidence: 99%

Trans-Stilbenes in Commercial Grape Juices: Quantification Using HPLC Approaches

López-Hernández

Quirós

2016

IJMS

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Trans-stilbenes belong to the group of polyphenolic phytoalexins, and occur in many plant foods. These compounds have received great attention by researchers due to their well-known beneficial health effects. In the present study a chromatographic method that comprises the use of variable wavelength (VWD) and fluorescence (FLD) detectors in series for the analysis of trans-stilbenes is presented. The relation of peak-area obtained with both detectors is proposed as an alternative and complementary approach for the rapid identification of these phenolic compounds. The proposed method was applied to determine trans-stilbenes in commercial fruit juices. Trans-piceid was the most common trans-stilbene found in the samples analyzed. The method was validated in terms of linearity, sensitivity and repeatability. Appropriate sensitivity and good linearity (r2 > 0.9991) were achieved.

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Piceatannol: A Potential Futuristic Natural Stilbene as Fetal Haemoglobin Inducer

Cited by 6 publications

References 29 publications

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

A Comprehensive Review on the Chemotherapeutic Potential of Piceatannol for Cancer Treatment, with Mechanistic Insights

Complementary and alternative medicine use in thalassemia patients in Shiraz, southern Iran: A cross-sectional study

Trans-Stilbenes in Commercial Grape Juices: Quantification Using HPLC Approaches

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