Piceatannol induces regulatory T cells and modulates the inflammatory response and adipogenesis

Rakib, Ahmed; Mandal, Mousumi; Showkat, Anaum; Kiran, Sonia; Mazumdar, Soumi; Singla, Bhupesh; Bajwa, Amandeep; Kumar, Santosh; Park, Frank; Singh, Udai P.

doi:10.1016/j.biopha.2023.114514

Cited by 9 publications

(1 citation statement)

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“…To this end, plant products have served as the most ancient source of medication from the start of civilization [16]. According to recent data, around three quarters of the total global population still rely on plant-derived therapeutic agents [17].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols: Role in Modulating Immune Function and Obesity

Mamun,

Rakib,

Mandal

et al. 2024

Biomolecules

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Polyphenols, long-used components of medicinal plants, have drawn great interest in recent years as potential therapeutic agents because of their safety, efficacy, and wide range of biological effects. Approximately 75% of the world’s population still use plant-based medicinal compounds, indicating the ongoing significance of phytochemicals for human health. This study emphasizes the growing body of research investigating the anti-adipogenic and anti-obesity functions of polyphenols. The functions of polyphenols, including phenylpropanoids, flavonoids, terpenoids, alkaloids, glycosides, and phenolic acids, are distinct due to changes in chemical diversity and structural characteristics. This review methodically investigates the mechanisms by which naturally occurring polyphenols mediate obesity and metabolic function in immunomodulation. To this end, hormonal control of hunger has the potential to inhibit pro-obesity enzymes such as pancreatic lipase, the promotion of energy expenditure, and the modulation of adipocytokine production. Specifically, polyphenols affect insulin, a hormone that is essential for regulating blood sugar, and they also play a role, in part, in a complex web of factors that affect the progression of obesity. This review also explores the immunomodulatory properties of polyphenols, providing insight into their ability to improve immune function and the effects of polyphenols on gut health, improving the number of commensal bacteria, cytokine production suppression, and immune cell mediation, including natural killer cells and macrophages. Taken together, continuous studies are required to understand the prudent and precise mechanisms underlying polyphenols’ therapeutic potential in obesity and immunomodulation. In the interim, this review emphasizes a holistic approach to health and promotes the consumption of a wide range of foods and drinks high in polyphenols. This review lays the groundwork for future developments, indicating that the components of polyphenols and their derivatives may provide the answer to urgent worldwide health issues. This compilation of the body of knowledge paves the way for future discoveries in the global treatment of pressing health concerns in obesity and metabolic diseases.

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Section: Introductionmentioning

confidence: 99%

Polyphenols: Role in Modulating Immune Function and Obesity

Mamun,

Rakib,

Mandal

et al. 2024

Biomolecules

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Assessing Therapeutic Value and Side Effects of Key Botanical Compounds for Optimized Medical Treatments

Al‐Shuhaib,

Al‐Shuhaib

2024

Chemistry & Biodiversity

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Due to the significance of variable chemical groups across a wide spectrum of modern medicine, it is imperative to determine what is the most widely used group in medical applications with the fewest side effects. Ten compounds from ten chemical groups that are most commonly known for their medical uses were compared in terms of their therapeutic potential and side effects. The comparison among the selected compounds indicated the superiority of the flavonoids over other groups in the multitude of their utilizations and the lower side effects. Kaempferol and quercetin showed higher medical utilization with lower side effects. Whereas alkaloid compounds showed the lowest levels of medical use and the highest levels of side effects. Based on the comparison conducted, it is concluded to give priority to flavonoid compounds being used in medical applications because they exhibit the highest medical uses with the lowest side effects. Within flavonoids, kaempferol and quercetin are the two compounds that are highly recommended to be used in the widest range of medical applications. Serious caution should be considered before applying alkaloids to any medical service. Understanding the characteristics of these compounds can aid in developing safer and more effective treatments for medicinal plants.

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