Piceatannol Is Superior to Resveratrol at Suppressing Adipogenesis in Human Visceral Adipose-Derived Stem Cells

Abstract

Resveratrol (3,4′,5-trans-trihydroxystilbene) and piceatannol (3,3′,4′,5-trans-tetraphydroxystilbene) are major stilbene compounds that are predominantly present in various natural foods, such as berries and fruits. Both phytochemical compounds are consumed as dietary supplements to prevent various metabolic diseases and for their anti-aging properties. Adipose-derived stem cells from human visceral adipose tissue (vASCs) are a useful in vitro model for evaluating their adipogenic effect. Treatment with resveratrol and piceatannol significantly inhibited lipid accumulation in vASCs. Their effective concentrations were 5, 10, and 20 μM for inhibiting adipogenesis of vASCs. Interestingly, despite the similar chemical structures of the two compounds, piceatannol showed a higher anti-adipogenic effect at 20 μM than resveratrol in vASCs. Moreover, the inhibitory capacity of lipid droplet generation was higher for piceatannol at 20 μM than that of resveratrol. Piceatannol significantly attenuated the expression level of adipogenic markers (e.g., CCAAT/enhanced binding protein α (C/EBPα), peroxisome proliferator-activated receptor γ (PPARγ), and adipocyte fatty acid binding protein (aP2)) compared to resveratrol at the mRNA and protein levels. These results suggest that piceatannol is a superior anti-adipogenic compound compared to resveratrol in the vASC model of visceral obesity.

3-OH Phloretin Inhibits High-Fat Diet-Induced Obesity and Obesity-Induced Inflammation by Reducing Macrophage Infiltration into White Adipose Tissue

“…Although it is not yet clear why phloretin and 3-OH phloretin have different effects on adipocyte differentiation in vitro, one reason may be the increased number of hydroxyl groups in phloretin, resulting in improved physiological and chemical reactivity. This possibility can be supported by a previous report that piceatannol has a larger hydroxyl group (3,3′,4′,5-trans-tetraphydroxystilbene) on a benzene ring compared to resveratrol and also has a higher inhibitory effect on adipogenesis and obesity than resveratrol (3,4′,5-trans-trihydroxystilbene) control [ 32 ]. In addition, a higher number of hydroxyl groups on the polyphenol structure leads to significantly higher biological activities by enhancing interactions between polyphenols and cell membrane surfaces via increased hydrogen bond formation [ 33 , 34 ].…”

A Review on Rhubarb-Derived Substances as Modulators of Cardiovascular Risk Factors—A Special Emphasis on Anti-Obesity Action

“…Its ability to suppress the macrophage interactions with adipocytes may be an important mechanism of alleviation of inflammatory processes in the adipose tissue [ 92 ]. Moreover, recent data suggest that piceatannol may be a more effective inhibitor of adipogenesis in human visceral adipose-derived stem cells than resveratrol [ 93 ].…”

Piceatannol: um estilbeno natural com um espectro amplo de atividades biológicas

“…Research, Society and Development, v. 11, n. 9, e49211932221, 2022 (CC BY 4.0) Fan et al, 2022Leal et al, 2017Wijekoon et al, 2022Cardile et al, 2005Jiang et al, 2020Piotrowska et al, 2012Yamamoto et al, 2020Potter et al, 2002Matsui et al, 2010FerrignI et al, 1984Lee et al, 2022Know et al, 2022Algandaby e Al-Sawahli, 2021Yang et al, 2020Kroplewska et al, 2019Kido et al, 2020Shi et al, 2020Sato et al, 2022Baseggio et al, 2022Sáez et al, 2018Arai et al, 2016Banik et al, 2020Kawakami et al, 2014Kershaw e Kim, 2017Kukreja et al, 2014Osamudiamen et al, 2020Park et al, 2021Setoguchi et al, 2014King et al, 1956Silva et al, 2021Misuzaki et al, 2017Pan et al, 2020Zomer et al, 2022Viñas et al, 2011Vinãs et al, 2009Zachová et al, 2018Avendaño-Godoy et al, 2022Lai et al, 2014Rimando et al, 2004 Xie e Bolling, 2014 Ersan et al, 2020Ku et al, 2005Santos et al, 2017Boue et al, 2013 Fonte: Autores.…”

“…Além disso, os extratos de fontes vegetais naturais ricas em piceatannol também vêm sendo investigados acerca de suas atividades biológicas. Kido et al, 2020 et al, 2016;Banik et al, 2020;Kawakami et al, 2014;Kershaw e Kim, 2017;Kukreja et al, 2014;Osamudiamen et al, 2020;Park et al, 2021;Piotrowska et al, 2012;Potter et al, 2002;Setoguchi et al, 2014).…”