Piceatannol mediated regulation of deregulated signaling pathways in different cancers: Tumbling of the ninepins of molecular oncology

Abstract

With the recent technological advancements, a new golden era of natural products drug discovery has dawned. Increasingly it is being realized that structural modularity of many pharmacologically active products derived natural sources allows a building-block approach which can be exploited for analysis of regulation of deregulated oncogenic protein networks in different cancers. Piceatannol has been shown to effectively modulate JAK/STAT, Wnt/β-catenin, mTOR pathway in different cancers. In addition, certain hints have emerged which shed light on the regulation of microRNAs by piceatannol in some cancers. Regulation of deregulated oncogenic pathways by Piceatannol is gradually capturing attention and might be helpful in the multi-targeting of deregulated oncogenic networks in cancers.

The cancer preventive activity and mechanisms of prenylated resveratrol and derivatives

“…Therefore, some polyphenols with significant free radical scavenging activity, such as syringic acid, show neuroprotective activity ( Ogut et al, 2022a , Ogut et al, 2019 ). In addition to antioxidant activity, piceatannol also possesses apoptotic activity to cancer cell ( Nayyab et al, 2020 ). Previous study has indicated that these potent cytotoxic effects are accompanied by induction of DNA damage, increase of the proportion of cells in the sub-G(1) phase of cell cycle, and inhibition of reactive oxygen species (ROS) generation ( Jin et al, 2018 ).…”

Selective and oxidative stress-mediated cell death of MCF-7 cell line induced by terpinolene

“…In this respect, novel plant compounds with potential anti-cancer effects have been investigated in an increasing number of studies. Plant-derived natural products such as the phenolic compounds (Anantharaju et al 2016) (Nayyab et al 2020), alkaloids (Isah 2016) and terpenoids have recently gained interest due to the growing demand for discovering novel anti-cancer drug candidates (Tomko et al 2020) (Farooqi et al 2020). Molecular findings suggest that these natural products can act on major signaling mechanisms such as the JAK/STAT, Wnt/β-catenin, mTOR pathways and TRAIL-mediated apoptosis (Sun et al 2019).…”