Pickering emulsions stabilised with oligoglycine-functionalised nanodiamond as a model system for ocular drug delivery applications

Moiseev, Roman; Melides, Solomon S.; Bae, Wooli; Jurewicz, Izabela; Khutoryanskiy, Vitaliy V.; Keddie, Joseph L.

doi:10.1039/d3sm00495c

Cited by 6 publications

(2 citation statements)

References 77 publications

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“…[2][3][4] Pickering emulsions, where stabilization is achieved via solid particles, have also been widely reported in the literature. [5][6][7] Emulsions find use in several applications, such as in food industry, 8 and enhanced oil recovery. 9 Emulsions are also used in healthcare applications as drug carriers, by solubilizing hydrophobic drugs and thus increasing their bioavailability.…”

Section: Introductionmentioning

confidence: 99%

An environmentally friendly synergistic stabilization of emulsions using an ABC macrosurfactant and hydroxypropyl methylcellulose

Constantinou,

Somuncuoğlu,

Georgiou

2024

Journal of Polymer Science

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Here, a series of non‐ionic ABC based on the hydrophilic oligo‐ and di‐(ethylene glycol) methyl ether methacrylate (OEGMA300/A and DEGMA/C), and the hydrophobic n‐butyl methacrylate (BuMA, B) are investigated as macrosurfactants. Polymers of constant composition, and four varying molar masses (MM) were synthesized via group transfer polymerization. The higher the MM, the bigger the micelles in aqueous media, and the lower the critical micellization concentration and the stability of oil‐in‐water emulsions. The best‐performing macrosurfactant was investigated under different conditions and it was proven that the oil phase volume fraction, and surfactant concentration strongly control the emulsion stability. The macrosurfactants show minimal dependence on the salinity of the water phase, thus offering suitability in preparation of emulsion in environments with different hardness. Emulsions stabilized by both the macrosurfactant and hydroxypropyl methylcellulose (HPMC), a naturally derived viscosity modifier, present a classical non‐Newtonian behavior; the viscosity increased when increasing the MM of the HPMC. The emulsion stabilization is attributed to the synergistic steric stabilization provided by the macrosurfactant and the increased viscosity and formation of an entangled network by HPMC. This formulation leads to emulsion stability over 65% 1 year after emulsification, highlighting its potential use in commercial applications.

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Section: Introductionmentioning

confidence: 99%

An environmentally friendly synergistic stabilization of emulsions using an ABC macrosurfactant and hydroxypropyl methylcellulose

Constantinou,

Somuncuoğlu,

Georgiou

2024

Journal of Polymer Science

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“…(Cui et al 2023). To impart physical stability, classical emulsi ers (e.g., surfactants) (Ngenda Tshilumbu and Fester 2023) and particulate matter (Huang et al 2023) are used. Stabilization of emulsions with solid particles (Pickering emulsions) has a number of advantages, which in general include higher physical stability, lower toxicity and the ability to impart new properties to the object, characteristic of the introduced solid particles (Mikhaylov et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical properties of sunflower oil Pickering emulsions stabilized by cellulose nanocrystals-chitosan complex

Mikhaylov,

Torlopov,

Vaseneva

et al. 2024

Preprint

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In this study we investigated the use of a polyelectrolyte complex formed by cellulose nanocrystals (CNC) and chitosan (Chit) as a stabilizing agent for Pickering emulsions. We demonstrated that chitosan reduces surface charge of CNC, resulting in polyelectrolyte complexes that efficiently stabilize emulsions. Emulsification processes reveal that a slight change in chitosan concentration can recharge surface of CNC. An optimal stabilizing complex containing 1% chitosan gives emulsions with minimal zeta potential, droplet size, creaming index values, along with high stability during storage, change in pH, and application of high centrifugal forces. The study also shows that the maximum neutralized surface charge of the CNC in the CNC-Chit complex allows for effective adsorption on the surface of sunflower oil droplets, producing a denser stabilizing layer with smaller droplet size. Also, chitosan addition is linked to improved stability and higher viscosity, with little dependence on ionic strength and temperature. Potentiometric titration allowed to reveal that five-time less chitosan is needed to neutralize surface charge of acetylated CNC compared to sulfated CNC. It is established that the CNC-Chit ratio eliminates background electrolyte ion participation in neutralizing surface charge, resulting in the absence of characteristic pKa values of the initial components. Wettability on a hydrophilic surface depends on the surface charge of the complex, enhancing wettability and adhesion performance with increased chitosan content. Also, we showed that tuning of stabilizer composition can change bioaccessability of lipophilic compounds during oral administration.

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Cellulose nanocrystal/chitosan ratio in Pickering stabilizers regulates vitamin D3 release

Mikhaylov,

Torlopov,

Vaseneva

et al. 2024

Colloid Polym Sci

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Pickering emulsions stabilised with oligoglycine-functionalised nanodiamond as a model system for ocular drug delivery applications

Abstract: Oil-in-water emulsions, stabilised with conventional surfactants, are commonly used in eye drops for ocular drug delivery. However, the presence of surfactants can sometimes irritate tissues. Furthermore, conventional emulsions often have...

Cited by 6 publications

References 77 publications

An environmentally friendly synergistic stabilization of emulsions using an ABC macrosurfactant and hydroxypropyl methylcellulose

An environmentally friendly synergistic stabilization of emulsions using an ABC macrosurfactant and hydroxypropyl methylcellulose

Physico-chemical properties of sunflower oil Pickering emulsions stabilized by cellulose nanocrystals-chitosan complex

Cellulose nanocrystal/chitosan ratio in Pickering stabilizers regulates vitamin D3 release

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