Pickering emulsions stabilized by partially acetylated cellulose nanocrystals for oral administration: oils effect and in vivo toxicity

Biocompatible Nanoparticle Heteroaggregates as Stabilizers of Pickering Emulsions for Vitamin D3 Efficient Delivery

“…At the same time, decreased ζ potential values of CNC after the addition of oppositely charged AlOOH nanoparticles are the factor providing the formation of stable emulsions. The initial CNC in the absence of electrolytes is ineffective in oil droplet stabilization, possibly due to the strong electrostatic repulsive forces between the nanoparticles and insufficient wettability at the droplet interface in the absence of electrolytes, which inhibits the adsorption of the nanoparticles at the oil/water interface. The addition of boehmite nanoparticles at a concentration of >9 mass % leads to an effective lowering of ζ potential values of the initial CNC (Figures and ) and promotes hybrid particle adsorption on the surface of oil droplets during emulsification.…”

“…Regardless of the organic/inorganic particle ratio, a decrease in the viscosity of the samples with an increase in the shear rate was observed in all cases. Consequently, the resulting systems exhibit pseudoplastic properties characteristic of Pickering o/w emulsions stabilized only by CNC of this (partially acetylated) type …”

“…Z-Average values were used as particle size for plotting graphs. The study of the acid–base properties of hybrid particles and emulsions was carried out according to the previously published paper . To study the rheological properties of emulsions, freshly prepared samples were used after storing them for 72 h. The study was carried out using a DV-III Ultra rheometer (Brookfield).…”

“…Pickering emulsion has been prepared using a broad spectrum of organic and inorganic colloidal systems of various shapes, charges, aspect ratios, and sizes. − Some types of particles have strong electrostatic repulsive forces, which are needed to be reduced to effectively emulsify oil in water to prepare stable Pickering emulsions . The most popular approach to surface charge reduction is the addition of supporting electrolytes . However, electrolyte addition directly affects the ionic strength and osmotic pressure.…”

“…6 The most popular approach to surface charge reduction is the addition of supporting electrolytes. 7 However, electrolyte addition directly affects the ionic strength and osmotic pressure. Thus, variation in electrolyte concentration or composition when administered to living beings or introduced to food or cosmetic products can lead to droplet coalescence and even emulsion destruction since every system has its own specific composition.…”