Picosecond alexandrite laser for Naevus of Ota treatment in Chinese

Peng, Lixin; Yang, Yin; Ge, Yiping; Lin, Tong

doi:10.1111/jdv.14810

Cited by 12 publications

(17 citation statements)

References 7 publications

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“…PS lasers showed superiority over the Q‐switched laser in treatment of nevus of Ota in past studies, and our experience has shown similar efficacy and superiority over Q‐switched lasers with fewer sessions and less side effects . Moderate to excellent results were seen in our study and in those prior …”

Section: Discussionsupporting

confidence: 75%

Retrospective photographic review of nontattoo indications treated by picosecond laser

Mehrabi

Friedman

Al‐Niaimi

et al. 2020

J of Cosmetic Dermatology

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Dermatology is a rapidly advancing field with many technologies added to the expanding armamentarium of the physician, particularly in the cosmetic sector of the specialty. Patients of all age groups and backgrounds seek treatment for skin conditions; these range from young adults with acne and acne scarring to the elderly requiring skin rejuvenation. energy-based devices (EBDs) are increasingly frequently used for the treatment of different aesthetic dermatological problems. Every technology offers a different mechanism of action, recovery timescale, and adverse effects. New technologies are becoming costlier, and this may have implications on the ratio of service to cost-effectiveness. A well-tolerated EBD procedure that can effectively treat different skin types and multiple skin conditions with minimal adverse effects and shortened downtime might be more economically attractive due to its versatility and favorability among patients and treating physicians alike.Picosecond (PS) lasers were approved by the US FDA in 2012 for the removal of tattoos. 1 The iconic feature of the PS laser is that its pulse duration is less than a nanosecond, achieving a photoacoustic effect and limiting the amount of thermal damage delivered to surrounding tissue. 2,3 Aside from tattoo removal, PS Abstract Background: Picosecond (PS) lasers were approved by the US FDA in 2012 after being shown to remove tattoos with more success and fewer treatments compared with traditional methods. PS lasers were shown to be versatile, indicated for the treatment of lentigines, café-au-lait macules (CALMs), and acne scars and skin rejuvenation. Objective:We report our experience treating our patients for different indications using a PS laser. Methods:We performed a retrospective chart and photographic review of all patients seen between 2016 and 2018 that were treated in our centers with a PS laser for nontattoo indications. Clinical outcomes were evaluated using side-by-side comparisons of the clinical photographs by two blinded, independent physicians using a visual analog scale consisting of six levels of treatment response. Results: A total of 233 patients were studied. Most sought treatment for solar lentigo (27%) and skin rejuvenation (14%). Epidermal nevi exhibited the greatest improvement with treatment, while acne scarring demonstrated the least. Only 24% of patients experienced noteworthy, transient adverse effects. Conclusion: Picosecond lasers were efficacious and safe for a variety of indications. They were effective in treating epidermal nevi and pigmented lesions, such as Lentigines and CALMs. K E Y W O R D S aesthetic improvement, epidermal nevus, laser treatment, picosecond laser, solar lentigines | 613 MEHRABI Et Al.

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Section: Discussionsupporting

confidence: 75%

Retrospective photographic review of nontattoo indications treated by picosecond laser

Mehrabi

Friedman

Al‐Niaimi

et al. 2020

J of Cosmetic Dermatology

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“…These results were achieved utilizing a 2–4 mm spot and 1.96–6.37 J/cm 2 . The rate of PIH was reported as 7% [19]. In the case of Hori's macules, the picosecond alexandrite laser demonstrated clear superiority as compared with the nanosecond alexandrite laser in a 33 patient split‐face randomized, controlled trial conducted by Yu et al The picosecond alexandrite laser settings were 2–2.5 mm spot size, 750 picoseconds pulse duration, and 4.07–6.37 J/cm 2 whereas the nanosecond device was utilized at a 3 mm spot size, 70 nanoseconds pulse duration, and 6–8 J/cm 2 .…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

“…Picosecond lasers with wavelengths of 532, 755, and 1064 nm have been reported to be safe and effective in the treatment of a wide range of discrete pigmented lesions including solar lentigines, freckles, verrucus epidermal nevus, café au lait macules (CALM), nevus of Ota, and Hori's macules. A total of five case reports/series; five retrospective reviews; three prospective open-label trials; and four split-face/lesion randomized comparison trials involving a cumulative 320 subjects have documented these findings [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29].…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

“…For Nevus of Ota, there have been two case series; two retrospective reviews; and one randomized split-lesion double-blind comparison trial study involving a cumulative total of 103 subjects [13,16,19,20,28]. In one retrospective review of 29 Chinese patients, a 750 picoseconds pulsed 755 nm picosecond alexandrite laser achieved >75% clearance in 40% of patients after two treatment sessions.…”

Section: Discrete Pigmented Lesionsmentioning

confidence: 99%

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A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

et al. 2020

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Background and Objectives The use of picosecond laser in dermatology was originally focused on optimizing the removal of unwanted tattoos. Subsequent advances in this technology have broadened its clinical indications to include treatment of benign pigmented lesions, photodamage, melasma, and scar revision. In this systematic review, evidence‐based recommendations are developed for the use of picosecond laser in dermatology. Study Design/Materials and Methods A comprehensive search of the English language literature was performed up to and including November 2019. Relevant citations were individually evaluated, synthesized, and categorized based on the Level of Evidence. With the addition of the authors’ combined clinical experience, clinical recommendations were developed. Results After application of inclusion and exclusion criteria, a total of 77 unique studies were evaluated. Treatment of benign pigmented lesions was associated with level I–IV evidence; rejuvenation was associated with level II evidence; melasma was associated with level II evidence; scar revision was associated with level II–III evidence; tattoo removal was associated with level I evidence. Conclusion Picosecond laser is a safe and effective treatment modality for an increasing range of dermatologic indications. Further development of this technology is warranted. Lasers Surg. Med. © 2020 Wiley Periodicals, Inc.

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“…A recent systematic review suggested that the PS laser is safe and effective for the management of pigmentary disorders, with levels of evidence of 1b for nevus of Ota and 2b for solar lentigines, but variable for other pigmentary lesions 15 . For nevus of Ota, previous studies reported good efficacy of the PS laser in different types of skins 22,29,33 . In particular, one study in Chinese patients reported a clearance rate of greater than 75% after two treatments with a 755‐nm PS alexandrite laser, with 7% of PIH 33 .…”

Section: Discussionmentioning

confidence: 99%

Treatment of pigmentary disorders using picosecond laser in Asian patients: A meta‐analysis and systematic review

Dong

Wang

Yuan

et al. 2021

Dermatologic Therapy

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There were many studies evaluating the effect of picosecond (PS) lasers, but no meta‐analysis examined the effects of PS laser in the treatment of pigmentary disorders in Asians. The aim of this article was to review the before‐after effect of PS laser in Asians for the treatment of pigmentary disorders. PubMed, Embase, and Cochrane library were searched for articles published up to May 2020. The evaluations were summarized into a 4‐point scale that ranged from <25% (poor), 25%‐50% (fair), 50%‐75% (good), and 75%‐100% (excellent). Effect sizes (ESs) were calculated according to laser wavelengths and lesion types. There were two randomized controlled trials, three single‐arm trials, and three case series, with 200 patients. At 3 months after treatment, of all included patients, 3% (95%CI: 1%‐6%) were evaluated as poor or worse, 9% (95%CI: 2%‐21%) as fair, 29% (95%CI: 12%‐50%) as good, and 56% (95%CI: 28%‐83%) as excellent. The 532 and 1064, and 755 nm PS lasers had similar ESs across all four response groups. This meta‐analysis suggested that 56% of Asian patients who underwent PS laser for the treatment of pigmentary disorders were evaluated as “excellent” about the pigment clearance by a dermatologist at least 3 months after treatment.

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Picosecond alexandrite laser for Naevus of Ota treatment in Chinese

Cited by 12 publications

References 7 publications

Retrospective photographic review of nontattoo indications treated by picosecond laser

Retrospective photographic review of nontattoo indications treated by picosecond laser

A Systematic Review of Picosecond Laser in Dermatology: Evidence and Recommendations

Treatment of pigmentary disorders using picosecond laser in Asian patients: A meta‐analysis and systematic review

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