Picrorhiza kurroa, Royle ex Benth:Traditional uses, phytopharmacology, and translational potential in therapy of fatty liver disease

Raut, Atul; Dhami-Shah, Hiteshi; Phadke, A.S; Shindikar, Anand; Udipi, Shobha; Joshi, Jayashree; Vaidya, Rama; Vaidya, Ashok D.B.

doi:10.1016/j.jaim.2022.100558

Cited by 8 publications

(4 citation statements)

References 51 publications

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“…As a result, it becomes a good option for natural appetite stimulant number. 10 The Emblica officinalis fruit is astringent in character and primarily composed of tannins, which have a significant potential for treating digestive illnesses like diarrhea and dysentery. It works well to reduce hyperacidity.…”

Section: Discussionmentioning

confidence: 99%

“…These properties work in concert to enhance digestion and lessen digestion-related issues including diarrhea, colitis, vomiting, hyperacidity, etc. [5][6][7][8][9][10][11][12][13][14][15][16][17][18] However, despite their widespread use, the efficacy and tolerability of these natural appetite stimulants in pediatric patients remain largely anecdotal and poorly understood.…”

Section: Durgaprasad Marathe* Pradyumna Ratnakar †mentioning

confidence: 99%

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A Survey to Assess the Efficacy and Tolerability of Natural Appetite Stimulants in Pediatric Patients

Durgaprasad Marathe,

Pradyumna Ratnakar

2023

IJCP

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Anorexia, a common symptom in children, leads to undernutrition, with over 60 million underweight children in India suffering from frequent illnesses. Lack of adequate diet, proper breastfeeding and sufficient protein contribute to increased incidence of undernutrition. Parents often complain their children don't eat enough, making mealtimes difficult and impeding growth. Appetite stimulants like cyproheptadine are available, but side effects like sedation, fatigue, disorientation, impaired coordination, restlessness, excitation and irritability limit their use especially in the pediatric population. The use of herbal supplements has increased worldwide, with parents seeking guidance from pediatricians and primary care professionals regarding the efficacy and safety of these products. The study was a retrospective study conducted via a questionnaire-based survey among all doctors between April and June 2023 to assess the efficacy and tolerability of natural appetite stimulants in pediatric patients. Results showed that patients in the age group of 0 to 5 years (23.1%) were the most common visitors in the doctor’s clinic and appetite stimulant agents were being prescribed most of the time (44.8%). They preferred prescribing natural appetite stimulant mostly (34.3%) for poor appetite (37.3%), followed by poor weight gain and growth (22.8%). The natural appetizer was found to nonaddictive and nonsedative with an improvement in the overall well-being (31.3%) among patients. The results suggest that the natural intervention has the potential to serve as a valuable adjunctive therapy in managing appetite challenges and promoting healthy weight gain in pediatric populations and to optimize pediatricnutrition and overall well-being.

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Section: Discussionmentioning

confidence: 99%

Section: Durgaprasad Marathe* Pradyumna Ratnakar †mentioning

confidence: 99%

A Survey to Assess the Efficacy and Tolerability of Natural Appetite Stimulants in Pediatric Patients

Durgaprasad Marathe,

Pradyumna Ratnakar

2023

IJCP

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“…300 mg of AEV01 is approximately equivalent to 3 g of raw herb. Safety and efficacy of the dose is supported by in-vitro, in-vivo and anecdotal evidence[ 12 ]. The drug was given orally in a dose of 1 capsule (100 mg) thrice daily after food for 30 days.…”

Section: Methodsmentioning

confidence: 99%

A randomized, placebo controlled, double blinded, parallel group clinical study to evaluate the efficacy and safety of AEV01 along with standard care for elderly patients with mild COVID-19

Balan,

Kannan,

Muralikumar

et al. 2024

Journal of Ayurveda and Integrative Medicine

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“…For most clinical indications, an adult should consume P. kurroa- Kutki rhizome powder at doses between 300 mg and 500 mg two to three times a day [ 104 ]. Clinical practices with P. kurroa have shown that its traditional preparations exhibit adverse symptoms, such as diarrhea, increased bowel frequency, abdominal gurgling, and abdominal colic syndrome [ 105 ]. Table 3 shows clinical trials involving P. kurroa in combination with other agents and P. kurroa (alone) for liver-related and other conditions.…”

Section: Classical and Clinical Use Of P Kurroamentioning

confidence: 99%

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

2022

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Traditional remedies for the treatment of various ailments are gaining popularity. Traditionally, one of the most valuable therapeutic herbs has been Picrorhiza kurroa Royle ex Benth. Traditional and folk uses of P. kurroa include chronic constipation, skin-related problems, burning sensation, chronic reoccurring fever, jaundice, heart problems, breathing, digestion, allergy, tuberculosis, blood-related problems, prediabetes and obesity, laxative, cholagogue, and liver stimulatory. Phytoconstituents such as glycosides, alkaloids, cucurbitacins, iridoids, phenolics, and terpenes in P. kurroa have shown promising pharmacological potential. In order to uncover novel compounds that may cure chronic illnesses, such as cardiovascular, diabetes, cancer, respiratory, and hepatoprotective diseases, the screening of P. kurroa is essential. This study comprehensively evaluated the ethnopharmacological efficacy, phytochemistry, pharmacological activity, dose, and toxicity of P. kurroa. This review provides comprehensive insights into this traditional medication for future research and therapeutic application. The purpose of this review article was to determine the pharmacological effects of P. kurroa on a variety of disorders. P. kurroa may be a natural alternative to the standard treatment for eradicating newly evolving diseases. This study is intended as a resource for future fundamental and clinical investigations.

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Picrorhiza kurroa, Royle ex Benth:Traditional uses, phytopharmacology, and translational potential in therapy of fatty liver disease

Cited by 8 publications

References 51 publications

A Survey to Assess the Efficacy and Tolerability of Natural Appetite Stimulants in Pediatric Patients

A Survey to Assess the Efficacy and Tolerability of Natural Appetite Stimulants in Pediatric Patients

A randomized, placebo controlled, double blinded, parallel group clinical study to evaluate the efficacy and safety of AEV01 along with standard care for elderly patients with mild COVID-19

Pharmacological and Clinical Efficacy of Picrorhiza kurroa and Its Secondary Metabolites: A Comprehensive Review

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