Picroside II protects myocardium from ischemia/reperfusion-induced injury through inhibition of the inflammatory response

Li, Jianzhe; Meiqing, Xie; Mo, Dan; Zhao, Xiaofang; Yu, Shuyi; Liu, Lijuan; Wu, Cheng; Yang, Yang

doi:10.3892/etm.2016.3841

Cited by 17 publications

(10 citation statements)

References 36 publications

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“…In the present study, changes in the haemodynamic parameters supported ischemia-reperfusion injury in the normal rat heart (Li et al 2016). The enzymes routinely measured in the clinical laboratory for the purpose of diagnosing and monitoring myocardial infarction included creatine kinase (CK) and lactate dehydrogenase (LDH).…”

Section: Discussionmentioning

confidence: 83%

Sufentanil protects the rat myocardium against ischemia–reperfusion injury via activation of the ERK1/2 pathway

Tao

Min

2017

Cytotechnology

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Sufentanil, a lipophilic opioid, is the most frequently used clinical drug for ischemic heart disease. The effects of sufentanil on MAPK signaling in ischemic heart disease were explored. The effects of sufentanil on ischemia-reperfusion (IR)-induced myocardial injury in a rat model were examined. The serum levels of CK, LDH, MDA and SOD, and the activities of Na-K-ATPase and Ca-Mg-ATPase were measured. The levels of total and phosphorylated ERK1/2, JNK, and p38 were measured by western blotting in the heart, and the myocardial H9C2 cell line was studied. Using the Cell Counting Kit-8, the growth rate of H9C2 cells affected by sufentanil was studied. The serum levels of CK, LDH and MDA were higher in the IR group than in the SO and SUF groups. The SOD level, as well as the activities of Na-K-ATPase and Ca-Mg-ATPase, were lower in the SO and SUF groups than in the IR group. The phosphorylated ERK1/2 level was lower in the IR group than in the SO and SUF groups. The growth rate of H9C2 cells increased with the concentration of sufentanil and the exposure time. The phosphorylated ERK level was upregulated by 4-12 h of sufentanil exposure, indicating that the effects were time-dependent. Furthermore, an inhibition of ERK signaling by chemical inhibition suppressed the sufentanil-mediated increase in the growth rate of H9C2 cells. Sufentanil appears to be beneficial for cases of worsening ischemic heart disease. Further studies are necessary before a clinical application is considered.

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Section: Discussionmentioning

confidence: 83%

Sufentanil protects the rat myocardium against ischemia–reperfusion injury via activation of the ERK1/2 pathway

Tao

Min

2017

Cytotechnology

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“…Interesting, treatment with picroside II before ischemia was able to protect from I/R injury also the myocardium as showed by the decrease in infarct size, cardiomyocyte apoptosis and activity of CK and LDH. According to the authors, these effects were partly due to the inhibition of the HMGB1-RAGE/TLR2/ TLR4-NfkB signaling pathway (31). The same pathway has been found to be affected by ethyl pyruvate (EP).…”

Section: Figurementioning

confidence: 99%

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases

et al. 2019

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Acute myocardial infarction (MI) and its consequences are the most common and lethal heart syndromes worldwide and represent a significant health problem. Following MI, apoptosis has been generally seen as the major contributor of the cardiomyocyte fate and of the resultant myocardial remodeling. However, in recent years, it has been discovered that, following MI, cardiomyocytes could activate autophagy in an attempt to protect themselves against ischemic stress and to preserve cardiac function. Although initially seen as two completely separate responses, recent works have highlighted the intertwined crosstalk between apoptosis and autophagy. Numerous researches have tried to unveil the mechanisms and the molecular players involved in this phenomenon and have identified in high-mobility group box 1 (HMGB1), a highly conserved non-histone nuclear protein with important roles in the heart, one of the major regulator. Thus, the aim of this mini review is to discuss how HMGB1 regulates these two responses in ischemic heart diseases. Indeed, a detailed understanding of the crosstalk between apoptosis and autophagy in these pathologies and how HMGB1 regulates them would be of tremendous help in developing novel therapeutic approaches aimed to promote cardiomyocyte survival and to diminish tissue injury following MI.

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“…Some literature pointed out that oral administration of the ethanol extract of RP could alleviate the myocardial damage caused by isoproterenol in rats, suggesting that RP had a certain protective effect on the heart (Senthil et al, ). Li et al () revealed that the pretreatment with picroside II could significantly alleviate I/R‐induced myocardial injury concomitantly with a decrease in inflammatory factor production. Picroside II also decreased the expression of high mobility group box1.…”

Section: Pharmacologymentioning

confidence: 99%

Chemical components, pharmacological actions, and clinical applications of Rhizoma Picrorhizae

Guo

Wei

Shen

et al. 2019

Phytotherapy Research

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Rhizoma Picrorhizae (RP) is a traditional Chinese medicine, which has always been used to treat many diseases like infantile epilepsy and malnutrition. In modern applications, it has been used to treat hepatitis B and various liver injuries with remarkable curative effects. So far, more than 90 chemical components have been reported in RP, mainly including iridoid glycosides, cucurbitacins, phenylethanoid glycosides, and phenolic glycosides. Among these, iridoid glycosides are the most important active ingredients, and about 30 such compounds have been isolated at present. In pharmacology, RP is beneficial to the choleresis, liver protection, anti-inflammation, asthma relief, immune regulation, and protection of heart, brain, kidney, and other organs.There have been many investigations on this medicinal herb in recent years, and it has attracted much attention in the medicine domain. In this paper, through systematically consulting the relevant books and electronic databases, we analyzed, arranged, and summarized the available information on this herb to provide reference for its further research. K E Y W O R D Sclinical use, iridoid glycosides, pharmacology, phytochemistry, Rhizoma Picrorhizae

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Picroside II protects myocardium from ischemia/reperfusion-induced injury through inhibition of the inflammatory response

Cited by 17 publications

References 36 publications

Sufentanil protects the rat myocardium against ischemia–reperfusion injury via activation of the ERK1/2 pathway

Sufentanil protects the rat myocardium against ischemia–reperfusion injury via activation of the ERK1/2 pathway

HMGB1-mediated apoptosis and autophagy in ischemic heart diseases

Chemical components, pharmacological actions, and clinical applications of Rhizoma Picrorhizae

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