Piezo-photodynamic therapy of Au@PEG-ZnO nanostructures enabled with a battery-free wireless cancer therapeutic dot

Han, Qian; Fang, Zengyi; Lin, Rui; Chen, Junyang; Wei, Xianhao; Gong, Cuicui; Yang, Zhixin; Zou, Pingjin; Zhu, Jingyuan; Xing, Lili; Xue, Xinyu; Lang, Jinyi; Zhou, Yi; Chen, Meihua

doi:10.1016/j.nanoen.2024.109530

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Physicians and healthcare systems need to focus on the growing cognizance that cancer patients can and should play an essential role in defining the rationalizing of optimal care, with counter-arguments to demonstrate what is safe and what is affordable, as not all patients need or respond to identical treatments. 4 Nanomedicine, an offshoot of nanotechnology, is an exponentially emerging and rapidly evolving field, and the use of nanoparticles (NPs), particularly gold nanoarchitecture (GNPs), 5 is attractive to candidates due to their unique physicochemical properties. They are extensively used in research for their applications in biomedicine with relatively high biocompatibility, synergistic therapeutic efficacy, and capability for less off-target toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Nanomedicine, an offshoot of nanotechnology, is an exponentially emerging and rapidly evolving field, and the use of nanoparticles (NPs), particularly gold nanoarchitecture (GNPs), is attractive to candidates due to their unique physicochemical properties. They are extensively used in research for their applications in biomedicine with relatively high biocompatibility, synergistic therapeutic efficacy, and capability for less off-target toxicity .…”

Section: Introductionmentioning

confidence: 99%

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Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma

Farooq,

Dovzhenko,

Zairov

et al. 2024

ACS Omega

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Chronic diseases, notably cancer, pose a significant global threat to human life. Oncologists and medical professionals addressing malignancies confront challenges such as toxicity and multidrug resistance. To tackle these issues, the focus has shifted toward the employment of multifunctional colloidal gold nanoparticles. This study aims to design pHsensitive doxorubicin-loaded gold nanoparticles using polyvinylpyrrolidone. The cytotoxic efficacy of the designed gold nanoarchitecture and its doxorubicin counterpart was assessed in an in vitro model using the HeLa cell. In comparison to the free drug, experimental evaluations showed that the gold nanoarchitecture outperformed significantly lower unspecific drug leaching and efficiently delivered the payload in a controlled manner, boosting the chemotherapy outcomes. This work opens a streamlined approach for engineering gold nanoarchitecture that could be further expanded to incorporate other therapeutics and/or functional moieties that require optimized controlled delivery, offering a one-size-fits-all solution and paving the revolutionary adjustments to healthcare procedures.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma

Farooq,

Dovzhenko,

Zairov

et al. 2024

ACS Omega

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Revealing the Optimization Route of Piezoelectric Sonosensitizers: From Mechanism to Engineering Methods

Zang,

Yu,

Zhang

et al. 2024

Small

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Piezoelectric catalysis is a novel catalytic technology that has developed rapidly in recent years and has attracted extensive interest among researchers in the field of tumor therapy for its acoustic‐sensitizing properties. Nevertheless, researchers are still controversial about the key technical difficulties in the modulation of piezoelectric sonosensitizers for tumor therapy applications, which is undoubtedly a major obstacle to the performance modulation of piezoelectric sonosensitizers. Clarification of this challenge will be beneficial to the design and optimization of piezoelectric sonosensitizers in the future. Here, the authors start from the mechanism of piezoelectric catalysis and elaborate the mechanism and methods of defect engineering and phase engineering for the performance modulation of piezoelectric sonosensitizers based on the energy band theory. The combined therapeutic strategy of piezoelectric sonosensitizers with enzyme catalysis and immunotherapy is introduced. Finally, the challenges and prospects of piezoelectric sonosensitizers are highlighted. Hopefully, the explorations can guide researchers toward the optimization of piezoelectric sonosensitizers and can be applied in their own research.

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Recent advances of piezoelectric materials used in sonodynamic therapy of tumor

Huang,

Miao,

2025

Coordination Chemistry Reviews

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Piezo-photodynamic therapy of Au@PEG-ZnO nanostructures enabled with a battery-free wireless cancer therapeutic dot

Cited by 3 publications

References 52 publications

Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma

Insights into the Engineered Gold Nanoparticle-Based Remedy for Supplementation Therapy of Ovarian Carcinoma

Revealing the Optimization Route of Piezoelectric Sonosensitizers: From Mechanism to Engineering Methods

Recent advances of piezoelectric materials used in sonodynamic therapy of tumor

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