Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species

Wang, Qimeng; Peng, Xuyun; Chen, Yifan; Tang, Xiaoyan; Qin, Yunfei; He, Meng; Chen, Wenjie; Chen, Hui

doi:10.1016/j.bbrc.2023.02.043

Cited by 8 publications

(4 citation statements)

References 35 publications

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“…Reactive oxygen species (ROS) are usually considered to be associated with the hepatotoxicity induced by APAP. 31 , 32 Under normal physiological conditions, ROS play crucial roles in cell signal transduction, regulation of vascular tone, and antimicrobial defense. However, when the production of ROS exceeds the body's clearance capacity, oxidative stress reactions may occur, resulting in cellular and tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism

Cai,

Xu,

Shen

et al. 2024

Journal of Traditional and Complementary Medicine

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Section: Discussionmentioning

confidence: 99%

Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism

Cai,

Xu,

Shen

et al. 2024

Journal of Traditional and Complementary Medicine

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“…In addition, in primary cultured mouse bladder urothelial cells, the downregulation of Piezo1 affects the reception of mechanical stimulation of the bladder, and the high expression of Piezo1 in the bladder indirectly indicates the important role ( Peyronnet et al, 2013 ). For the liver, Piezo1 alleviates acute liver injury caused by acetaminophen by activating nuclear factor erythroid 2-related factor 2 and reducing mitochondrial reactive oxygen species ( Wang Q. et al, 2023 ). In addition, inducing and inhibiting ferroptosis makes a contribution to the treatment of drug-resistant tumors, ischemic organ damage, and other degenerative diseases related to overwhelming lipid peroxidation ( Jiang X. et al, 2021 ; Hirata et al, 2023 ).…”

Section: Basic Information On Piezo1mentioning

confidence: 99%

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

Zhang,

Zou,

Dou

et al. 2024

Front. Physiol.

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Mechanosensitive ion channel protein 1 (Piezo1) is a large homotrimeric membrane protein. Piezo1 has various effects and plays an important and irreplaceable role in the maintenance of human life activities and homeostasis of the internal environment. In addition, recent studies have shown that Piezo1 plays a vital role in tumorigenesis, progression, malignancy and clinical prognosis. Piezo1 is involved in regulating the malignant behaviors of a variety of tumors, including cellular metabolic reprogramming, unlimited proliferation, inhibition of apoptosis, maintenance of stemness, angiogenesis, invasion and metastasis. Moreover, Piezo1 regulates tumor progression by affecting the recruitment, activation, and differentiation of multiple immune cells. Therefore, Piezo1 has excellent potential as an anti-tumor target. The article reviews the diverse physiological functions of Piezo1 in the human body and its major cellular pathways during disease development, and describes in detail the specific mechanisms by which Piezo1 affects the malignant behavior of tumors and its recent progress as a new target for tumor therapy, providing new perspectives for exploring more potential effects on physiological functions and its application in tumor therapy.

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“…Cell deformation activates membrane channels, such as the Piezo and TRPV family, causing a calcium ion influx into the cell. Both TRPV4 or Piezo1 potentially activate Nrf2 and reduce mitochondrial ROS, most likely superoxide [148]. Interestingly, mechanical loading possesses the ability to trigger glutathione-mediated stress resistance in cartilage, indicating a link between mechanotransduction and redox signaling [149].…”

Section: Mechanobiology and The Nrf2-keap1 System In Cartilagementioning

confidence: 99%

The Contribution of the Nrf2/ARE System to Mechanotransduction in Musculoskeletal and Periodontal Tissues

Fragoulis

Tohidnezhad

Kubo

et al. 2023

IJMS

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Mechanosensing plays an essential role in maintaining tissue functions. Across the human body, several tissues (i.e., striated muscles, bones, tendons, ligaments, as well as cartilage) require mechanical loading to exert their physiological functions. Contrary, mechanical unloading triggers pathological remodeling of these tissues and, consequently, human body dysfunctions. At the cellular level, both mechanical loading and unloading regulate a wide spectrum of cellular pathways. Among those, pathways regulated by oxidants such as reactive oxygen species (ROS) represent an essential node critically controlling tissue organization and function. Hence, a sensitive balance between the generation and elimination of oxidants keeps them within a physiological range. Here, the Nuclear Factor-E2-related factor 2/Antioxidant response element (Nrf2/ARE) system plays an essential role as it constitutes the major cellular regulation against exogenous and endogenous oxidative stresses. Dysregulations of this system advance, i.a., liver, neurodegenerative, and cancer diseases. Herein, we extend our comprehension of the Nrf2 system to the aforementioned mechanically sensitive tissues to explore its role in their physiology and pathology. We demonstrate the relevance of it for the tissues’ functionality and highlight the imperative to further explore the Nrf2 system to understand the physiology and pathology of mechanically sensitive tissues in the context of redox biology.

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Piezo1 alleviates acetaminophen-induced acute liver injury by activating Nrf2 and reducing mitochondrial reactive oxygen species

Cited by 8 publications

References 35 publications

Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism

Sophorae tonkinensis radix polysaccharide attenuates acetaminophen-induced liver injury by regulating the miR-140-5p-related antioxidant mechanism

Pleiotropic physiological functions of Piezo1 in human body and its effect on malignant behavior of tumors

The Contribution of the Nrf2/ARE System to Mechanotransduction in Musculoskeletal and Periodontal Tissues

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