Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Chen, Si; Zhu, Piao; Mao, Lijie; Wu, Wei; Han, Lin; Xu, Deliang; Lu, Xiangyu; Shi, Jianlin

doi:10.1002/adma.202208256

Cited by 118 publications

(68 citation statements)

References 165 publications

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“…[166,167] Sonopiezoelectric biomaterials have been extensively adopted in nerve regeneration owing to their distinctive ability to generate the built-in electric field under the irritation of external US. [168,169] Sonopiezoelectric stimulation as the desirable candidate for the targeted nerves has the advantages of wireless and non-invasiveness in contrast to the wired electrical case. [2] As an instance for this case, the US (0.8 W cm −2 , 1.0 MHz)-irradiated BTO achieved the wireless electrical stimulation for SH-SY5Y neuron-like cells by unfolding the voltage-gated channels to bring about the influx [162] Copyright 2022, Elsevier.…”

Section: Neural Regenerationmentioning

confidence: 99%

Sonopiezoelectric Nanomedicine and Materdicine

Wang

Dai

Chen

2023

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Endogenous electric field is ubiquitous in a multitude of important living activities such as bone repair, cell signal transduction, and nerve regeneration, signifying that regulating the electric field in organisms is highly beneficial to maintain organism health. As an emerging and promising research direction, piezoelectric nanomedicine and materdicine precisely activated by ultrasound with synergetic advantages of deep tissue penetration, remote spatiotemporal selectivity, and mechanical‐electrical energy interconversion, have been progressively utilized for disease treatment and tissue repair by participating in the modulation of endogenous electric field. This specific nanomedicine utilizing piezoelectric effect activated by ultrasound is typically regarded as “sonopiezoelectric nanomedicine”. This comprehensive review summarizes and discusses the substantially employed sonopiezoelectric nanomaterials and nanotherapies to provide an insight into the internal mechanism of the corresponding biological behavior/effect of sonopiezoelectric biomaterials in versatile disease treatments. This review primarily focuses on the sonopiezoelectric biomaterials for biosensing, drug delivery, tumor therapy, tissue regeneration, antimicrobia, and further illuminates the underlying sonopiezoelectric mechanism. In addition, the challenges and developments/prospects of sonopiezoelectric nanomedicine are analyzed for promoting the further clinical translation. It is earnestly expected that this kind of nanomedicine/biomaterials‐enabled sonopiezoelectric technology will provoke the comprehensive investigation and promote the clinical development of the next‐generation multifunctional materdicine.

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Section: Neural Regenerationmentioning

confidence: 99%

Sonopiezoelectric Nanomedicine and Materdicine

Wang

Dai

Chen

2023

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“…In general, the power and voltage requirements for implantable biomedical devices typically range from microwatt (μW)–milliwatt (mW) and 2–3 V, respectively. 389,390…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

et al. 2023

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“…(3) 压-电-化学耦合在医疗领域的应用需要进一步探索。施剑林等人将压-电-化学耦应用到生物医学领域，将其称为"压电医学" [78] 。压-电-化学耦合可以被用来治疗肿瘤细胞。未来结合 B 超来实现诊断与治疗一体化值得进一步探索。此外，将压电材料与口腔护理相结合，利用刷牙过程中牙刷产生的振动，可以实现压-电-化学耦合的牙齿美白 [79] 。在压电医学方面，催化剂的生物安全性、生…”

Section: 展望unclassified

Research progress in enhancement strategies and mechanisms of piezo-electro-chemical coupling

Yao¹,

Wang²,

Zhang³

et al. 2023

Acta Phys. Sin.

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Piezoelectric materials can harvest tiny mechanical energy existing in the environment, and have a strong ability to convert mechanical signals into electrical signals. Piezo-electro-chemical coupling can be realized via coupling piezoelectric effect of piezoelectric materials and electrochemical redox effect. In recent years, piezo-electro-chemical coupling has attracted a lot of attention from researchers in harvesting vibration energy to treat dye wastewater. The piezoelectric catalyst material dispersed in solution is deformed by ultrasonic vibrations with applied stress. Based on the piezoelectric and spontaneous polarization effects, positive and negative charges are generated at both ends of the catalyst, which can further react with dissolved oxygen and hydroxide ions in the solution to generate superoxide and hydroxyl radicals (·O<sub>2</sub>-and ·OH) for decomposing organic dyes. However, ordinary piezoelectric catalytic materials are often difficult to meet people's pursuit of efficient treatment of organic dyes. Researchers have conducted a lot of research on piezo-electro-chemical coupling, mainly focusing on the following two aspects: 1) the modification of piezoelectric catalysts to achieve extended carrier lifetime, accelerated carrier separation and high piezoelectric coefficients. 2) The combination of piezo-electro-chemical coupling with photocatalysis to suppress photogenerated carrier compounding to obtain high synergistic catalytic performance. In this work, the following five strategies to enhance the piezo-electro-chemical coupling via modifying piezoelectric catalyst materials are introduced. The heterojunction structure is constructed to promote the separation of electron-hole pairs. The precious metal is coated on the surface of the catalyst to accelerate the transport and transfer of electrons. The catalyst composition is regulated and controlled to obtain an increased piezoelectric coefficient at the phase boundary. Carbon or graphene are mixed in the catalyst to accelerate the electron transfer on the surface of piezoelectric materials. The number of active sites is increased through introducing defects in the catalyst to increase the concentration of carriers. The physical mechanisms of five different strategies are described from the perspectives of electrons transport and transfer, phase transition and oxygen vacancies. In addition, prospects for piezoelectric chemical coupling in energy and biomedical applications such as hydrogen production, carbon dioxide reduction, tumor therapy and tooth whitening are presented.

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Cited by 118 publications

References 165 publications

Sonopiezoelectric Nanomedicine and Materdicine

Sonopiezoelectric Nanomedicine and Materdicine

Perspectives on recent advancements in energy harvesting, sensing and bio-medical applications of piezoelectric gels

Research progress in enhancement strategies and mechanisms of piezo-electro-chemical coupling

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