2024
DOI: 10.1002/adma.202403979
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Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain

Yifei Yin,
Peiran Zhao,
Xianyun Xu
et al.

Abstract: The manipulation of cell surface receptors’ activity will open a new frontier for drug development and disease treatment. However, limited by the desensitization of drugs, effective physical intervention strategy remains challenging. Here, the controllable internalization of transient receptor potential vanilloid 1 (TRPV1) on neural cells by local piezoelectric field is reported. Single‐cell‐level local electric field is construct by synthesizing piezoelectric BiOIO3 nanosheets (BIONSs). Upon a mild ultrasound… Show more

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