Piezoelectric and Dielectric Electrospun Fluoropolymer Membranes for Oral Mucosa Regeneration: A Comparative Study

Chernova, Ulyana V.; Varakuta, Elena Yu.; Koniaeva, Anastasiia D.; Leyman, Arina E.; Sagdullaeva, Sofia A.; Plotnikov, Evgenii; Melnik, Evgeniy Yu.; Tran, Tuan-Hoang; Rutkowski, Sven; Kudryavtseva, Valeriya L.; Buznik, Vyacheslav M.; Bolbasov, Evgeniy

doi:10.1021/acsami.4c01867

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…Nanostructured membranes represent the most common form of nanostructured materials, as they might contain nanofibers, which are further able to support nanoparticles loading the active substance, as described by Chen P. et al and Chernova U. et al [ 11 , 36 ]; moreover, the therapeutic agent can be embedded into their structure, according to research by Liu X. et al [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review

Muresan,

Boca,

Lucaciu

et al. 2024

Biomimetics

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Background and Objectives: Two of the most exciting new technologies are biotechnology and nanotechnology. The science of nanostructures, or nanotechnology, is concerned with the development, testing, and use of structures and molecules with nanoscale dimensions ranging from 1 to 100 nm. The development of materials and tools with high specificity that interact directly at the subcellular level is what makes nanotechnology valuable in the medical sciences. At the cellular or tissue level, this might be converted into focused clinical applications with the greatest possible therapeutic benefits and the fewest possible side effects. The purpose of the present study was to review the literature and explore the applicability of the nanostructured materials in the process of the regeneration of the soft and hard tissues of the oral cavity. Materials and Methods: An electronic search of articles was conducted in several databases, such as PubMed, Embase, and Web of Science, to conduct this study, and the 183 articles that were discovered were chosen and examined, and only 22 articles met the inclusion criteria in this review. Results: The findings of this study demonstrate that using nanoparticles can improve the mechanical properties, biocompatibility, and osteoinductivity of biomaterials. Conclusions: Most recently, breakthroughs in tissue engineering and nanotechnology have led to significant advancements in the design and production of bone graft substitutes and hold tremendous promise for the treatment of bone abnormalities. The creation of intelligent nanostructured materials is essential for various applications and therapies, as it allows for the precise and long-term delivery of medication, which yields better results.

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Section: Discussionmentioning

confidence: 99%

The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review

Muresan,

Boca,

Lucaciu

et al. 2024

Biomimetics

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Electrospinning of polyetherketoneketone fibers: The effect of fabrication regime on the morphology, physico-chemical and biological characteristics

Goreninskii,

Melnik,

Plotnikov

et al. 2024

Polymer

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Effects of biocompatible piezoelectric membranes on the development of fibrosis associated with the oral mucosal wound regeneration

Koniaeva,

Varakuta,

Leiman

et al. 2024

BRSMU

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Prevention of fibrosis during the oral mucosal wound regeneration is a pressing issue of today’s surgical dentistry. The study was aimed to perform morphological assessment of the effects of biocompatible piezoelectric membranes on fibrous tissue formation during regeneration of the oral mucosal wounds. We assessed cell–cell interactions of macrophages and fibroblasts, along with changes in the CD68 and TGFβ1 marker expression and their effects on the development of fibrosis under conditions of using biocompatible polymeric membranes with piezoelectric properties at various stages of the oral mucosal wound defect regeneration. Comparative morphological assessment of the oral mucosal structures was conducted in animals having intact mucosa (n = 15), having open wound defects (n = 15), and having wounds covered with biocompatible piezoelectric membranes (n = 15). Biomaterial was collected from the wound defect site on days 3, 7, and 12 of the experiment; collection of biomaterial from intact animals was performed on the same days. In the group, where biocompatible membranes were used, signs of proliferation phase at the defect site were detected as early as on day 3 of the study; the faster shift from macrophage infiltration to fibroblast infiltration, the decline in inflammatory response were detected on day 7; restoration of the numerical density of macrophages and fibroblasts to the intact values was detected on day 12. The expression of CD68 and TGFβ1, the prognostic markers of fibrosis, was lower in the group, where no membranes were used. Reduction of the dense fibrous connective tissue specific area was observed at the microscopic level, severe soft tissue deformation was reported at the macroscopic level. In the group with no wound covering, extensive cell infiltration and increased CD68 and TGFβ1 expression persisted throughout the experiment, which resulted in the fact that specific area of dense fibrous connective tissue was larger, than that of loose connective tissue, on day 12 of the study, as well as in the cicatricial soft tissue deformities.

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Piezoelectric and Dielectric Electrospun Fluoropolymer Membranes for Oral Mucosa Regeneration: A Comparative Study

Cited by 4 publications

References 65 publications

The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review

The Applicability of Nanostructured Materials in Regenerating Soft and Bone Tissue in the Oral Cavity—A Review

Electrospinning of polyetherketoneketone fibers: The effect of fabrication regime on the morphology, physico-chemical and biological characteristics

Effects of biocompatible piezoelectric membranes on the development of fibrosis associated with the oral mucosal wound regeneration

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