Piezoelectric and Magnetoelectric Scaffolds for Tissue Regeneration and Biomedicine: A Review

Ferson, Noah D.; Uhl, Amanda M.; Andrew, Jennifer S.

doi:10.1109/tuffc.2020.3020283

Cited by 22 publications

(23 citation statements)

References 95 publications

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“…[18] Currently, there are several examples and techniques for obtaining magnetoelectric composite materials based on PVDF and P(VDF-TrFE) with Fe 3 O 4 , CoFe 2 O 4 , terfenol-D, and other magnetic particles. [2] Studies devoted to the fabrication of PVDF or P(VDF-TrFE)/Fe 3 O 4 composites include different sample preparation techniques, [19][20][21][22][23][24][25] among which solvent casting and electrospinning are the most widely used techniques.…”

Section: Introductionmentioning

confidence: 99%

“…The development of piezoelectric, magnetoactive, and magnetoelectric materials is an actively developing area of modern materials science given a wide range of practical applications, mainly in medicine. [ 1,2 ] Magnetic and magnetoelectric composites are used in the targeted drug delivery systems and various methods of noninvasive therapy in cardiology, traumatology, neurology, and therapeutic applications. [ 3 ] In addition, materials with magnetoelectric properties make it possible to influence cells of various tissues of the human body and improve their physiological functions.…”

Section: Introductionmentioning

confidence: 99%

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Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Ботвин

Surmeneva

Mukhortova

et al. 2022

Polymer Engineering & Sci

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The development of functional magnetoactive materials fabricated in the form of electrospun scaffolds is of paramount importance for modern medicine and pharmaceuticals. To precisely control the morphology and magnetic properties of the composite magnetoactive scaffolds, the electrospinning conditions, incorporation method of magnetic particles into the polymer solution to avoid agglomeration, and the shape/size of the particles should be thoroughly studied. In this study, hybrid magnetoactive scaffolds based on poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TrFE)), doped with either unmodified magnetite (Fe 3 O 4 ) or magnetite particles modified with oleic acid (Fe 3 O 4 /OA), have been fabricated by electrospinning. Modification of magnetite particles by oleic acid results in the formation of nanosized particles in comparison with submicron-sized Fe 3 O 4 particles (37 vs. 329 nm), which reveal a greater affinity to P(VDF-TrFE) due to their hydrophobic surface. Composite scaffolds prepared using 30 wt% polymer solution with 8 wt% Fe 3 O 4 and Fe 3 O 4 /OA reveal saturation magnetization values of 9.14 and 5.8 emu/g, respectively. The saturation magnetization of composite scaffolds agrees well with the saturation magnetization of the initial magnetites. Considering the better dispersion of Fe 3 O 4 /OA in the polymer solution, a series of composite scaffolds with 4 and

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Ботвин

Surmeneva

Mukhortova

et al. 2022

Polymer Engineering & Sci

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“…Several reports have applied magnetoelectric composites as drug carriers [24] and tissue engineering scaffolds [25]. Nair et al.…”

Section: Introductionmentioning

confidence: 99%

Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO₂ nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film

Qin

Tang

et al. 2022

Biosurface and Biotribology

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It is challenging to match the mutual interactions between implant and host because the biomaterials usually cannot actively adjust their performance to the changing microenvironment. Surface potential is one of the critical factors affecting the bioactivity of biomaterials, but it is difficult to be directly controlled in vivo. Magnetic stimulation has attracted much attention due to its deep penetrability, good reliability, and convenient operability. Here, titanium dioxide (TiO2) nanotubes and Terfenol‐D/P(VDF‐TrFE) composite film are prepared by anodic oxidation and solution casting methods on opposite sides of a titanium sheet, respectively. Terfenol‐D magnetostrictive microparticles deform under a magnetic field, generating surface potential on the P(VDF‐TrFE) piezoelectric matrix through magneto‐electric coupling. Correspondingly, equal opposite charges are induced on the surface of TiO2 nanotubes. Stem cells cultured on TiO2 nanotubes show that cell adhesion, proliferation, and differentiation abilities can be regulated by magnetic strength, which correlates with the absorption of charged proteins. Therefore, a cascade coupling of magnetic, mechanical, electric, biochemical, and cellular effects is established. This work demonstrates the feasibility of regulating the bioactivity of biomaterials in vivo through a magnetic field.

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“…2,3,11 The ability of magnetoelectric compounds such as PVDF− CFO nanocomposites to transduce signals, namely, magnetic to electric, can be used to produce scaffolds for tissue engineering capable of dynamic electrical stimulation by generating surface electric potential variations upon magnetic solicitation. 12,13 These functional 3D culture supports emulate the native environment and ECM properties of tissues which are highly dependent on electrical stimulus such as the nervous system, cardiac muscle, or bone.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Additionally, this can be achieved remotely through magnetic fields. , The action of an applied magnetic field induces movement and deformation of CFO particles which, in turn, deforms the PVDF polymer matrix and originates an electric field in any point of a 3D culture by surface electric charge density variation at the surface of the microspheres, due to the piezoelectric properties of the material. , It is worth noting that the piezoelectric properties of PVDF are originated by the polar arrangement of its crystal structure in β or γ crystalline forms. It is thus relevant that the crystallization of PVDF in the microspheres takes place preferentially in any of these phases …”

Section: Introductionmentioning

confidence: 99%

Microfluidic Processing of Piezoelectric and Magnetic Responsive Electroactive Microspheres

Martins

Ródenas-Rochina

Salazar

et al. 2022

ACS Appl. Polym. Mater.

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Poly(vinylidene fluoride) (PVDF) combined with cobalt ferrite (CFO) particles is one of the most common and effective polymeric magnetoelectric composites. Processing PVDF into its electroactive phase is a mandatory condition for featuring electroactive behavior and specific (post)processing may be needed to achieve this state, although electroactive phase crystallization is favored at processing temperatures below 60 °C. Different techniques are used to process PVDF−CFO nanocomposite structures into microspheres with high CFO dispersion, with microfluidics adding the advantages of high reproducibility, size tunability, and time and resource efficiency. In this work, magnetoelectric microspheres are produced in a one-step approach. We describe the production of high content electroactive phase PVDF and PVDF−CFO microspheres using microfluidic technology. A flow-focusing polydimethylsiloxane device is fabricated based on a 3D printed polylactic acid master, which enables the production of spherical microspheres with mean diameters ranging from 80 to 330 μm. The microspheres feature internal and external cavernous structures and good CFO distribution with an encapsulation efficacy of 80% and prove to be in the electroactive γ-phase with a mean content of 75%. The microspheres produced using this approach show suitable characteristics as active materials for tissue regeneration strategies and other piezoelectric polymer applications.

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Piezoelectric and Magnetoelectric Scaffolds for Tissue Regeneration and Biomedicine: A Review

Cited by 22 publications

References 95 publications

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO₂ nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film

Microfluidic Processing of Piezoelectric and Magnetic Responsive Electroactive Microspheres

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Piezoelectric and Magnetoelectric Scaffolds for Tissue Regeneration and Biomedicine: A Review

Cited by 22 publications

References 95 publications

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Magnetoactive electrospun hybrid scaffolds based on poly(vinylidene fluoride‐co‐trifluoroethylene) and magnetite particles with varied sizes

Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO2 nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film

Microfluidic Processing of Piezoelectric and Magnetic Responsive Electroactive Microspheres

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Magnetic field regulation of mouse bone marrow mesenchymal stem cell behaviours on TiO₂ nanotubes via surface potential mediated by Terfenol‐D/P(VDF‐TrFE) film