Piezoelectric Effect and Growth Control in Bone

Marino, Andrew A.; Becker, Robert O.

doi:10.1038/228473a0

Cited by 142 publications

(88 citation statements)

References 7 publications

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“…The biomechanical properties of bone, in particular its piezoelectric activity, have been addressed microscopically [56] and macroscopically, with models using finite element analysis [57]. Further, it has been also hypothesized a mechanism by which the piezoelectric signals can regulate the bone growth [58]. At the cellular level, the bone cell type that plays an important role in the bone structure development and appears to be involved in bone mechanotransduction, the osteocytes, was identified [59].…”

Section: Bonementioning

confidence: 99%

Piezoelectric polymers as biomaterials for tissue engineering applications

Ribeiro

Sencadas

Correia

et al. 2015

Colloids and Surfaces B: Biointerfaces

423

338

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Tissue engineering often rely on scaffolds for supporting cell differentiation and growth. Novel paradigms for tissue engineering include the need of active or smart scaffolds in order to properly regenerate specific tissues. In particular, as electrical and electromechanical clues are among the most relevant ones in determining tissue functionality in tissues such as muscle and bone, among others, electroactive materials and, in particular, piezoelectric ones, show strong potential for novel tissue engineering strategies, in particular taking also into account the existence of these phenomena within some specific tissues, indicating their requirement also during tissue regeneration. This referee reports on piezoelectric materials used for tissue engineering applications. The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies. This review provides thus a compilation of the most relevant results and strategies and a start point for novel research pathways in the most relevant and challenging open questions. This referee reports on piezoelectric materials used for tissue engineering applications.The most used materials for tissue engineering strategies are reported together with the main achievements, challenges and future needs for research and actual therapies. This referee provides thus a compilation of the most relevant results and strategies and a start point for novel research pathways in the most relevant and challenging open questions.

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Section: Bonementioning

confidence: 99%

Piezoelectric polymers as biomaterials for tissue engineering applications

Ribeiro

Sencadas

Correia

et al. 2015

Colloids and Surfaces B: Biointerfaces

423

338

View full text Add to dashboard Cite

show abstract

“…For example, most biological systems ranging from wood to calcified and connective tissues are known to be piezoelectric [137][138][139][140] , as a result of combination of optical activity and polar bonding in bio macromolecules. These behaviors often average out in macroscopic biological assemblies, since the piezoelectric effect is described by third rank tensor.…”

Section: Iia Basic Pfmmentioning

confidence: 99%

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Vasudevan

Balke

Maksymovych

et al. 2017

Applied Physics Reviews

270

206

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Ferroelectric materials have remained one of the foci of condensed matter physics and materials science for over 50 years. In the last 20 years, the development of voltage-modulated scanning probe microscopy techniques, exemplified by Piezoresponse force microscopy (PFM) and associated time-and voltage spectroscopies, opened a pathway to explore these materials on a single-digit nanometer level. Consequently, domain structures, walls and polarization dynamics can now be imaged in real space. More generally, PFM has allowed studying electromechanical coupling in a broad variety of materials ranging from ionics to biological systems. It can also be anticipated that the recent Nobel prize 1 in molecular electromechanical machines will result in rapid growth in interest in PFM as a method to probe their behavior on single device and device assembly levels. However, the broad introduction of PFM also resulted in a growing number of reports on nearly-ubiquitous presence of ferroelectric-like phenomena including remnant polar states and electromechanical hysteresis loops in materials which are non-ferroelectric in the bulk, or in cases where size effects are expected to suppress ferroelectricity. While in certain cases plausible physical mechanisms can be suggested, there is remarkable similarity in observed behaviors, irrespective of the materials system. In this review, we summarize the basic principles of PFM, briefly discuss the features of ferroelectric surfaces salient to PFM imaging and spectroscopy, and summarize existing reports on ferroelectric-like responses in non-classical ferroelectric materials. We further discuss possible mechanisms behind observed behaviors, and possible experimental strategies for their identification.3

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“…The direct effect has been linked with the ability of bone to grow and remodel in response to directionally-dependent applied stress [3]. Studies of macroscopic electromechanical coupling have shown that collagenous tissues such as bone, tendon, dentin, and skin [3][4][5][6] all exhibit piezoelectricity. Fibril-forming collagens are composed of collagen molecules, which are hydrogen bond-stabilized, triple helical molecules consisting of three polypeptide chains [7].…”

Section: Introductionmentioning

confidence: 99%

Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels

et al. 2012

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Assembling artificial collagenous tissues with structural, functional, and mechanical properties, which mimic natural tissues, is of vital importance for many tissue engineering applications. While the electromechanical properties of collagen are thought to play a role in, e.g., bone formation and remodeling, this functional property has not been adequately addressed in engineered tissues. Here, the electromechanical properties of rat tail tendon are compared with those of dried iso-electrically focused collagen hydrogels using piezoresponse force microscopy in ambient conditions. In both the natural tissue and the engineered hydrogel, D-periodic, type I collagen fibrils are observed, which exhibit shear piezoelectricity. While both tissues also exhibit fibrils with parallel orientation, Fourier transform analysis has revealed that the degree of parallel alignment of the fibrils in the tendon is three times that of the dried hydrogel. The results obtained demonstrate that iso-electrically focused collagen has similar structural and electromechanical properties to that of tendon, which is relevant for tissue engineering applications.

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Piezoelectric Effect and Growth Control in Bone

Cited by 142 publications

References 7 publications

Piezoelectric polymers as biomaterials for tissue engineering applications

Piezoelectric polymers as biomaterials for tissue engineering applications

Ferroelectric or non-ferroelectric: Why so many materials exhibit “ferroelectricity” on the nanoscale

Electromechanical properties of dried tendon and isoelectrically focused collagen hydrogels

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