Piezoelectric nanogenerators for self‐powered wearable and implantable bioelectronic devices

Das, Kuntal Kumar; Basu, Bikramjit; Maiti, Pralay; Dubey, Ashutosh Kumar

doi:10.1016/j.actbio.2023.08.057

Cited by 21 publications

(2 citation statements)

References 230 publications

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“…The best piezoelectric polymer class is led by poly(vinylidene fluoride) (PVDF) and its copolymers, with a piezoelectric coefficient in the order of 20 pC/N [21]. As a fluoropolymer, PVDF is thermally and chemically stable and thus non-biodegradable, and so it may activate a fibrotic capsule formation as a drawback [22]. However, due to its remarkable piezoelectric properties, PVDF is currently studied for engineering mechanically responsive tissues, such as bone and lung [18,23].…”

Section: Introductionmentioning

confidence: 99%

3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering

Strangis,

Labardi,

Gallone

et al. 2024

Bioengineering

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Bone defects are a significant health problem worldwide. Novel treatment approaches in the tissue engineering field rely on the use of biomaterial scaffolds to stimulate and guide the regeneration of damaged tissue that cannot repair or regrow spontaneously. This work aimed at developing and characterizing new piezoelectric scaffolds to provide electric bio-signals naturally present in bone and vascular tissues. Mixing and extrusion were used to obtain nanocomposites made of polyhydroxybutyrate (PHB) as a matrix and barium titanate (BaTiO3) nanoparticles as a filler, at BaTiO3/PHB compositions of 5/95, 10/90, 15/85 and 20/80 (w/w%). The morphological, thermal, mechanical and piezoelectric properties of the nanocomposites were studied. Scanning electron microscopy analysis showed good nanoparticle dispersion within the polymer matrix. Considerable increases in the Young’s modulus, compressive strength and the piezoelectric coefficient d31 were observed with increasing BaTiO3 content, with d31 = 37 pm/V in 20/80 (w/w%) BaTiO3/PHB. 3D printing was used to produce porous cubic-shaped scaffolds using a 90° lay-down pattern, with pore size ranging in 0.60–0.77 mm and good mechanical stability. Biodegradation tests conducted for 8 weeks in saline solution at 37 °C showed low mass loss (∼4%) for 3D printed scaffolds. The results obtained in terms of piezoelectric, mechanical and chemical properties of the nanocomposite provide a new promising strategy for vascularized bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering

Strangis,

Labardi,

Gallone

et al. 2024

Bioengineering

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“…Electroactive biomaterials can influence the microenvironment between cells and a material's surface by controlling surface electrical signals, thereby affecting cellular physiological activities [1][2][3][4]. Electroactive biomaterials include ferroelectric, piezoelectric [5,6], electret [7,8], and conductive materials [9], among others.…”

Section: Introductionmentioning

confidence: 99%

PVTF Nanoparticles/PLA Electroactive Degradable Membrane for Bone Tissue Regeneration

Shi,

Xu,

et al. 2024

Coatings

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Electroactive biomaterials can influence the microenvironment between cells and a material’s surface by controlling surface electrical signals, thereby affecting cellular physiological activities. As the most commonly used ferroelectric polymer, Poly(vinylidene fluoride-trifluoroethylene) (PVTF) has attracted widespread attention due to its good stability, biocompatibility and mechanical properties. However, it has limitations such as non-degradability. In this study, PVTF nanoparticles (PVTF NPs), prepared using a phase separation method, were compounded with polylactide (PLA) to prepare PVTF NPs/PLA composite membrane (PN/PLA), which simultaneously achieved electroactivity and degradability. PVTF NPs containing ferroelectric β phase were evenly distributed on the PLA substrate, forming negative potential spots through corona polarization. The PLA substrate gradually degraded in a simulated body fluid environment. The negative surface potential provided by PVTF NPs in PN/PLA enhanced the adhesion, proliferation, and early-stage osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The electrical bioactivity and degradability could be joined together in this study, which is promising for tissue regeneration biomaterials, such as guided bone regeneration membrane.

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Electrical Microneedles for Wound Treatment

Wang,

Cai,

Fan

et al. 2024

Advanced Science

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Electrical stimulation has been hotpot research and provoked extensive interest in a broad application such as wound closure, tissue injury repair, and nerve engineering. In particular, immense efforts have been dedicated to developing electrical microneedles, which demonstrate unique features in terms of controllable drug release, real‐time monitoring, and therapy, thus greatly accelerating the process of wound healing. Here, a review of state‐of‐art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of the mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted. Finally, current perspectives and directions for the development of future electrical microneedles in improving wound healing are addressed.

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Piezoelectric nanogenerators for self‐powered wearable and implantable bioelectronic devices

Cited by 21 publications

References 230 publications

3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering

3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering

PVTF Nanoparticles/PLA Electroactive Degradable Membrane for Bone Tissue Regeneration

Electrical Microneedles for Wound Treatment

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