This chapter is focused on describing the latest advances related to the development of bio-piezoelectric coatings for bone regeneration applications. It starts with the description of the main concepts about bioelectrical phenomena in the human body and its role in the regeneration of bone. It explains concepts such as dielectric and electrical responses that includes piezoelectricity, pyroelectricity, and ferroelectricity and how the human bone can present these types of phenomena. The chapter also includes the definition of bio-ceramic materials and bioactive coatings, and a summary of the main bio-ceramic coatings employed nowadays for applications in bone tissue regeneration. Also, this chapter includes a review of the latest advances in the development of bio-piezoelectric coatings for bone tissue engineering and future perspectives on this topic. Overall, this chapter is focused on reviewing comprehensively the electrical response of natural tissues and the relevance of bio-piezoelectric ceramics for bone tissue regeneration.